Multi-micronutrient fortified rice improved serum zinc and folate concentrations of Cambodian school children. A double-blinded cluster-randomized controlled trial

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Multi-micronutrient fortified rice improved serum zinc and folate concentrations of Cambodian school children. A double-blinded cluster-randomized controlled trial. / Kuong, Khov; Tor, Pety; Perignon, Marlene; Fiorentino, Marion; Chamnan, Chhoun; Berger, Jacques; Burja, Kurt; Dijkhuizen, Marjoleine Amma; Parker, Megan; Roos, Nanna; Wieringa, Frank T.

I: Nutrients, Bind 11, Nr. 12, 2843, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Kuong, K, Tor, P, Perignon, M, Fiorentino, M, Chamnan, C, Berger, J, Burja, K, Dijkhuizen, MA, Parker, M, Roos, N & Wieringa, FT 2019, 'Multi-micronutrient fortified rice improved serum zinc and folate concentrations of Cambodian school children. A double-blinded cluster-randomized controlled trial', Nutrients, bind 11, nr. 12, 2843. https://doi.org/10.3390/nu11122843

APA

Kuong, K., Tor, P., Perignon, M., Fiorentino, M., Chamnan, C., Berger, J., Burja, K., Dijkhuizen, M. A., Parker, M., Roos, N., & Wieringa, F. T. (2019). Multi-micronutrient fortified rice improved serum zinc and folate concentrations of Cambodian school children. A double-blinded cluster-randomized controlled trial. Nutrients, 11(12), [2843]. https://doi.org/10.3390/nu11122843

Vancouver

Kuong K, Tor P, Perignon M, Fiorentino M, Chamnan C, Berger J o.a. Multi-micronutrient fortified rice improved serum zinc and folate concentrations of Cambodian school children. A double-blinded cluster-randomized controlled trial. Nutrients. 2019;11(12). 2843. https://doi.org/10.3390/nu11122843

Author

Kuong, Khov ; Tor, Pety ; Perignon, Marlene ; Fiorentino, Marion ; Chamnan, Chhoun ; Berger, Jacques ; Burja, Kurt ; Dijkhuizen, Marjoleine Amma ; Parker, Megan ; Roos, Nanna ; Wieringa, Frank T. / Multi-micronutrient fortified rice improved serum zinc and folate concentrations of Cambodian school children. A double-blinded cluster-randomized controlled trial. I: Nutrients. 2019 ; Bind 11, Nr. 12.

Bibtex

@article{fb047b16f3794b3baac7604d48864097,
title = "Multi-micronutrient fortified rice improved serum zinc and folate concentrations of Cambodian school children. A double-blinded cluster-randomized controlled trial",
abstract = "Background: Within Cambodia, micronutrient deficiencies continue to be prevalent in vulnerable groups, such as women and children. Fortification of staple foods such as rice could be a promising strategy for Cambodia to improve micronutrient status.Objective: Our objective was to investigate the impact of multiple-micronutrient fortified rice (MMFR), distributed through a World Food Program school-meals program (WFP-SMP) on serum zinc concentrations and folate status in a double-blind, cluster-randomized, placebo-controlled trial.Methods: Sixteen schools were randomly assigned to receive one of three different types of extruded-fortified rice (UltraRice Original (URO), UltraRice New (URN), or NutriRice) or unfortified rice (placebo) six days a week for six months. A total of 1950 schoolchildren (6-16 years old) participated in the study. Serum zinc (all groups) and folate (only in NutriRice and placebo group) concentrations were assessed from morning non-fasting antecubital blood samples and were measured at three time points (baseline and after three and six months).Results: After six months of intervention, serum zinc concentrations were significantly increased in all fortified rice group compared to placebo and baseline (0.98, 0.85 and 1.40 µmol/L for URO, URN and NutriRice, respectively) (interaction effect: p < 0.001 for all). Children in the intervention groups had a risk of zinc deficiencies of around one third (0.35, 039, and 0.28 for URO, URN, and NutriRice, respectively) compared to the placebo (p < 0.001 for all). The children receiving NutriRice had higher serum folate concentrations at endline compared to children receiving normal rice (+ 2.25 ng/mL, p = 0.007).Conclusions: This study showed that the high prevalence of zinc and folate deficiency in Cambodia can be improved through the provision of MMFR. As rice is the staple diet for Cambodia, MMFR should be considered to be included in the school meal program and possibilities should be explored to introduce MMFR to the general population.",
keywords = "Faculty of Science, Fortified rice, Micronutrient, Deficiency, Zinc, School children, Cambodia",
author = "Khov Kuong and Pety Tor and Marlene Perignon and Marion Fiorentino and Chhoun Chamnan and Jacques Berger and Kurt Burja and Dijkhuizen, {Marjoleine Amma} and Megan Parker and Nanna Roos and Wieringa, {Frank T}",
note = "CURIS 2019 NEXS 363",
year = "2019",
doi = "10.3390/nu11122843",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "12",

}

RIS

TY - JOUR

T1 - Multi-micronutrient fortified rice improved serum zinc and folate concentrations of Cambodian school children. A double-blinded cluster-randomized controlled trial

AU - Kuong, Khov

AU - Tor, Pety

AU - Perignon, Marlene

AU - Fiorentino, Marion

AU - Chamnan, Chhoun

AU - Berger, Jacques

AU - Burja, Kurt

AU - Dijkhuizen, Marjoleine Amma

AU - Parker, Megan

AU - Roos, Nanna

AU - Wieringa, Frank T

N1 - CURIS 2019 NEXS 363

PY - 2019

Y1 - 2019

N2 - Background: Within Cambodia, micronutrient deficiencies continue to be prevalent in vulnerable groups, such as women and children. Fortification of staple foods such as rice could be a promising strategy for Cambodia to improve micronutrient status.Objective: Our objective was to investigate the impact of multiple-micronutrient fortified rice (MMFR), distributed through a World Food Program school-meals program (WFP-SMP) on serum zinc concentrations and folate status in a double-blind, cluster-randomized, placebo-controlled trial.Methods: Sixteen schools were randomly assigned to receive one of three different types of extruded-fortified rice (UltraRice Original (URO), UltraRice New (URN), or NutriRice) or unfortified rice (placebo) six days a week for six months. A total of 1950 schoolchildren (6-16 years old) participated in the study. Serum zinc (all groups) and folate (only in NutriRice and placebo group) concentrations were assessed from morning non-fasting antecubital blood samples and were measured at three time points (baseline and after three and six months).Results: After six months of intervention, serum zinc concentrations were significantly increased in all fortified rice group compared to placebo and baseline (0.98, 0.85 and 1.40 µmol/L for URO, URN and NutriRice, respectively) (interaction effect: p < 0.001 for all). Children in the intervention groups had a risk of zinc deficiencies of around one third (0.35, 039, and 0.28 for URO, URN, and NutriRice, respectively) compared to the placebo (p < 0.001 for all). The children receiving NutriRice had higher serum folate concentrations at endline compared to children receiving normal rice (+ 2.25 ng/mL, p = 0.007).Conclusions: This study showed that the high prevalence of zinc and folate deficiency in Cambodia can be improved through the provision of MMFR. As rice is the staple diet for Cambodia, MMFR should be considered to be included in the school meal program and possibilities should be explored to introduce MMFR to the general population.

AB - Background: Within Cambodia, micronutrient deficiencies continue to be prevalent in vulnerable groups, such as women and children. Fortification of staple foods such as rice could be a promising strategy for Cambodia to improve micronutrient status.Objective: Our objective was to investigate the impact of multiple-micronutrient fortified rice (MMFR), distributed through a World Food Program school-meals program (WFP-SMP) on serum zinc concentrations and folate status in a double-blind, cluster-randomized, placebo-controlled trial.Methods: Sixteen schools were randomly assigned to receive one of three different types of extruded-fortified rice (UltraRice Original (URO), UltraRice New (URN), or NutriRice) or unfortified rice (placebo) six days a week for six months. A total of 1950 schoolchildren (6-16 years old) participated in the study. Serum zinc (all groups) and folate (only in NutriRice and placebo group) concentrations were assessed from morning non-fasting antecubital blood samples and were measured at three time points (baseline and after three and six months).Results: After six months of intervention, serum zinc concentrations were significantly increased in all fortified rice group compared to placebo and baseline (0.98, 0.85 and 1.40 µmol/L for URO, URN and NutriRice, respectively) (interaction effect: p < 0.001 for all). Children in the intervention groups had a risk of zinc deficiencies of around one third (0.35, 039, and 0.28 for URO, URN, and NutriRice, respectively) compared to the placebo (p < 0.001 for all). The children receiving NutriRice had higher serum folate concentrations at endline compared to children receiving normal rice (+ 2.25 ng/mL, p = 0.007).Conclusions: This study showed that the high prevalence of zinc and folate deficiency in Cambodia can be improved through the provision of MMFR. As rice is the staple diet for Cambodia, MMFR should be considered to be included in the school meal program and possibilities should be explored to introduce MMFR to the general population.

KW - Faculty of Science

KW - Fortified rice

KW - Micronutrient

KW - Deficiency

KW - Zinc

KW - School children

KW - Cambodia

U2 - 10.3390/nu11122843

DO - 10.3390/nu11122843

M3 - Journal article

C2 - 31756911

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 12

M1 - 2843

ER -

ID: 230692614