Lifelong football training: Effects on autophagy and healthy longevity promotion

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Standard

Lifelong football training: Effects on autophagy and healthy longevity promotion. / Mancini, Annamaria; Vitucci, Daniela; Randers, Morten Bredsgaard; Schmidt, Jakob Friis; Hagman, Marie; Andersen, Thomas Rostgaard; Imperlini, Esther; Mandola, Annalisa; Orrù, Stefania; Krustrup, Peter; Buono, Pasqualina.

I: Frontiers in Physiology, Bind 10, 132, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Mancini, A, Vitucci, D, Randers, MB, Schmidt, JF, Hagman, M, Andersen, TR, Imperlini, E, Mandola, A, Orrù, S, Krustrup, P & Buono, P 2019, 'Lifelong football training: Effects on autophagy and healthy longevity promotion', Frontiers in Physiology, bind 10, 132. https://doi.org/10.3389/fphys.2019.00132

APA

Mancini, A., Vitucci, D., Randers, M. B., Schmidt, J. F., Hagman, M., Andersen, T. R., Imperlini, E., Mandola, A., Orrù, S., Krustrup, P., & Buono, P. (2019). Lifelong football training: Effects on autophagy and healthy longevity promotion. Frontiers in Physiology, 10, [132]. https://doi.org/10.3389/fphys.2019.00132

Vancouver

Mancini A, Vitucci D, Randers MB, Schmidt JF, Hagman M, Andersen TR o.a. Lifelong football training: Effects on autophagy and healthy longevity promotion. Frontiers in Physiology. 2019;10. 132. https://doi.org/10.3389/fphys.2019.00132

Author

Mancini, Annamaria ; Vitucci, Daniela ; Randers, Morten Bredsgaard ; Schmidt, Jakob Friis ; Hagman, Marie ; Andersen, Thomas Rostgaard ; Imperlini, Esther ; Mandola, Annalisa ; Orrù, Stefania ; Krustrup, Peter ; Buono, Pasqualina. / Lifelong football training: Effects on autophagy and healthy longevity promotion. I: Frontiers in Physiology. 2019 ; Bind 10.

Bibtex

@article{0a635391925348cc9e46264a757a1bce,
title = "Lifelong football training: Effects on autophagy and healthy longevity promotion",
abstract = "Aging is a physiological process characterized by a progressive decline of biological functions and an increase in destructive processes in cells and organs. Physical activity and exercise positively affects the expression of skeletal muscle markers involved in longevity pathways. Recently, a new mechanism, autophagy, was introduced to the adaptations induced by acute and chronic exercise as responsible of positive metabolic modification and health-longevity promotion. However, the molecular mechanisms regulating autophagy in response to physical activity and exercise are sparsely described. We investigated the long-term adaptations resulting from lifelong recreational football training on the expression of skeletal muscle markers involved in autophagy signaling. We demonstrated that lifelong football training increased the expression of messengers: RAD23A, HSPB6, RAB1B, TRAP1, SIRT2, and HSBPB1, involved in the auto-lysosomal and proteasome-mediated protein degradation machinery; of RPL1, RPL4, RPL36, MRLP37, involved in cellular growth and differentiation processes; of the Bcl-2, HSP70, HSP90, PSMD13, and of the ATG5-ATG12 protein complex, involved in proteasome promotion and autophagy processes in muscle samples from lifelong trained subjects compared to age-matched untrained controls. In conclusion, our results indicated that lifelong football training positively influence exercise-induced autophagy processes and protein quality control in skeletal muscle, thus promoting healthy aging.",
keywords = "Faculty of Science, Football, Lifelong training, Longevity, Cardiovascular capacity, Autophagy",
author = "Annamaria Mancini and Daniela Vitucci and Randers, {Morten Bredsgaard} and Schmidt, {Jakob Friis} and Marie Hagman and Andersen, {Thomas Rostgaard} and Esther Imperlini and Annalisa Mandola and Stefania Orr{\`u} and Peter Krustrup and Pasqualina Buono",
note = "CURIS 2019 NEXS 090",
year = "2019",
doi = "10.3389/fphys.2019.00132",
language = "English",
volume = "10",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Lifelong football training: Effects on autophagy and healthy longevity promotion

AU - Mancini, Annamaria

AU - Vitucci, Daniela

AU - Randers, Morten Bredsgaard

AU - Schmidt, Jakob Friis

AU - Hagman, Marie

AU - Andersen, Thomas Rostgaard

AU - Imperlini, Esther

AU - Mandola, Annalisa

AU - Orrù, Stefania

AU - Krustrup, Peter

AU - Buono, Pasqualina

N1 - CURIS 2019 NEXS 090

PY - 2019

Y1 - 2019

N2 - Aging is a physiological process characterized by a progressive decline of biological functions and an increase in destructive processes in cells and organs. Physical activity and exercise positively affects the expression of skeletal muscle markers involved in longevity pathways. Recently, a new mechanism, autophagy, was introduced to the adaptations induced by acute and chronic exercise as responsible of positive metabolic modification and health-longevity promotion. However, the molecular mechanisms regulating autophagy in response to physical activity and exercise are sparsely described. We investigated the long-term adaptations resulting from lifelong recreational football training on the expression of skeletal muscle markers involved in autophagy signaling. We demonstrated that lifelong football training increased the expression of messengers: RAD23A, HSPB6, RAB1B, TRAP1, SIRT2, and HSBPB1, involved in the auto-lysosomal and proteasome-mediated protein degradation machinery; of RPL1, RPL4, RPL36, MRLP37, involved in cellular growth and differentiation processes; of the Bcl-2, HSP70, HSP90, PSMD13, and of the ATG5-ATG12 protein complex, involved in proteasome promotion and autophagy processes in muscle samples from lifelong trained subjects compared to age-matched untrained controls. In conclusion, our results indicated that lifelong football training positively influence exercise-induced autophagy processes and protein quality control in skeletal muscle, thus promoting healthy aging.

AB - Aging is a physiological process characterized by a progressive decline of biological functions and an increase in destructive processes in cells and organs. Physical activity and exercise positively affects the expression of skeletal muscle markers involved in longevity pathways. Recently, a new mechanism, autophagy, was introduced to the adaptations induced by acute and chronic exercise as responsible of positive metabolic modification and health-longevity promotion. However, the molecular mechanisms regulating autophagy in response to physical activity and exercise are sparsely described. We investigated the long-term adaptations resulting from lifelong recreational football training on the expression of skeletal muscle markers involved in autophagy signaling. We demonstrated that lifelong football training increased the expression of messengers: RAD23A, HSPB6, RAB1B, TRAP1, SIRT2, and HSBPB1, involved in the auto-lysosomal and proteasome-mediated protein degradation machinery; of RPL1, RPL4, RPL36, MRLP37, involved in cellular growth and differentiation processes; of the Bcl-2, HSP70, HSP90, PSMD13, and of the ATG5-ATG12 protein complex, involved in proteasome promotion and autophagy processes in muscle samples from lifelong trained subjects compared to age-matched untrained controls. In conclusion, our results indicated that lifelong football training positively influence exercise-induced autophagy processes and protein quality control in skeletal muscle, thus promoting healthy aging.

KW - Faculty of Science

KW - Football

KW - Lifelong training

KW - Longevity

KW - Cardiovascular capacity

KW - Autophagy

U2 - 10.3389/fphys.2019.00132

DO - 10.3389/fphys.2019.00132

M3 - Journal article

C2 - 30837897

VL - 10

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 132

ER -

ID: 214683553