Is protein the forgotten ingredient: Effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Is protein the forgotten ingredient: Effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials. / Vogtschmidt, Yakima D; Raben, Anne; Faber, Ilona; de Wilde, Claudia; Lovegrove, Julie A; Givens, D Ian; Pfeiffer, Andreas F H; Soedamah-Muthu, Sabita S.

I: Atherosclerosis, Bind 328, 2021, s. 124-135.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Vogtschmidt, YD, Raben, A, Faber, I, de Wilde, C, Lovegrove, JA, Givens, DI, Pfeiffer, AFH & Soedamah-Muthu, SS 2021, 'Is protein the forgotten ingredient: Effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials', Atherosclerosis, bind 328, s. 124-135. https://doi.org/10.1016/j.atherosclerosis.2021.05.011

APA

Vogtschmidt, Y. D., Raben, A., Faber, I., de Wilde, C., Lovegrove, J. A., Givens, D. I., Pfeiffer, A. F. H., & Soedamah-Muthu, S. S. (2021). Is protein the forgotten ingredient: Effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials. Atherosclerosis, 328, 124-135. https://doi.org/10.1016/j.atherosclerosis.2021.05.011

Vancouver

Vogtschmidt YD, Raben A, Faber I, de Wilde C, Lovegrove JA, Givens DI o.a. Is protein the forgotten ingredient: Effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials. Atherosclerosis. 2021;328:124-135. https://doi.org/10.1016/j.atherosclerosis.2021.05.011

Author

Vogtschmidt, Yakima D ; Raben, Anne ; Faber, Ilona ; de Wilde, Claudia ; Lovegrove, Julie A ; Givens, D Ian ; Pfeiffer, Andreas F H ; Soedamah-Muthu, Sabita S. / Is protein the forgotten ingredient: Effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials. I: Atherosclerosis. 2021 ; Bind 328. s. 124-135.

Bibtex

@article{1d08485e4ee44e3180eb211b5eeeaad7,

title = "Is protein the forgotten ingredient: Effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials",

abstract = "Background and aims: Higher protein (HP) diets may lead to lower cardiometabolic risk, compared to lower protein (LP) diets. This systematic review and meta-analysis aims to investigate the effects of HP versus LP diets on cardiometabolic risk factors in adults, using the totality of the current evidence from randomised controlled trials (RCTs).Methods: Systematic searches were conducted in electronic databases, up to November 2020. Random effects meta-analyses were conducted to pool the standardised mean differences (SMD) and 95% confidence intervals (CI). The main outcomes were weight loss, body mass index (BMI), waist circumference, fat mass, systolic and diastolic BP, total cholesterol, HDL-and LDL-cholesterol, triacylglycerol, fasting glucose and insulin, and glycated haemoglobin.Results: Fifty-seven articles reporting on 54 RCTs were included, involving 4344 participants (65% female, mean age: 46 (SD 10) years, mean BMI: 33 (SD 3) kg/m2), with a mean study duration of 18 weeks (range: 4 to 156 weeks). Compared to LP diets (range protein (E%):10-23%), HP diets (range protein (E%): 20-45%) led to more weight loss (SMD -0.13, 95% CI: -0.23, -0.03), greater reductions in fat mass (SMD -0.14, 95% CI: -0.24, -0.04), systolic BP (SMD -0.12, 95% CI: -0.21, -0.02), total cholesterol (SMD -0.11, 95% CI: -0.19, -0.02), triacylglycerol (SMD -0.22, 95% CI: -0.30, -0.14) and insulin (SMD -0.12, 95% CI: -0.22, -0.03). No significant differences were observed for the other outcomes.Conclusions: Higher protein diets showed small, but favourable effects on weight loss, fat mass loss, systolic blood pressure, some lipid outcomes and insulin, compared to lower protein diets.",

keywords = "Faculty of Science, Cardiometabolic, Meta-analysis, Protein diet, Randomised controlled trial, Systematic review",

author = "Vogtschmidt, {Yakima D} and Anne Raben and Ilona Faber and {de Wilde}, Claudia and Lovegrove, {Julie A} and Givens, {D Ian} and Pfeiffer, {Andreas F H} and Soedamah-Muthu, {Sabita S}",

year = "2021",

doi = "10.1016/j.atherosclerosis.2021.05.011",

language = "English",

volume = "328",

pages = "124--135",

journal = "Journal of atherosclerosis research",

issn = "1567-5688",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Is protein the forgotten ingredient: Effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials

AU - Vogtschmidt, Yakima D

AU - Raben, Anne

AU - Faber, Ilona

AU - de Wilde, Claudia

AU - Lovegrove, Julie A

AU - Givens, D Ian

AU - Pfeiffer, Andreas F H

AU - Soedamah-Muthu, Sabita S

PY - 2021

Y1 - 2021

N2 - Background and aims: Higher protein (HP) diets may lead to lower cardiometabolic risk, compared to lower protein (LP) diets. This systematic review and meta-analysis aims to investigate the effects of HP versus LP diets on cardiometabolic risk factors in adults, using the totality of the current evidence from randomised controlled trials (RCTs).Methods: Systematic searches were conducted in electronic databases, up to November 2020. Random effects meta-analyses were conducted to pool the standardised mean differences (SMD) and 95% confidence intervals (CI). The main outcomes were weight loss, body mass index (BMI), waist circumference, fat mass, systolic and diastolic BP, total cholesterol, HDL-and LDL-cholesterol, triacylglycerol, fasting glucose and insulin, and glycated haemoglobin.Results: Fifty-seven articles reporting on 54 RCTs were included, involving 4344 participants (65% female, mean age: 46 (SD 10) years, mean BMI: 33 (SD 3) kg/m2), with a mean study duration of 18 weeks (range: 4 to 156 weeks). Compared to LP diets (range protein (E%):10-23%), HP diets (range protein (E%): 20-45%) led to more weight loss (SMD -0.13, 95% CI: -0.23, -0.03), greater reductions in fat mass (SMD -0.14, 95% CI: -0.24, -0.04), systolic BP (SMD -0.12, 95% CI: -0.21, -0.02), total cholesterol (SMD -0.11, 95% CI: -0.19, -0.02), triacylglycerol (SMD -0.22, 95% CI: -0.30, -0.14) and insulin (SMD -0.12, 95% CI: -0.22, -0.03). No significant differences were observed for the other outcomes.Conclusions: Higher protein diets showed small, but favourable effects on weight loss, fat mass loss, systolic blood pressure, some lipid outcomes and insulin, compared to lower protein diets.

AB - Background and aims: Higher protein (HP) diets may lead to lower cardiometabolic risk, compared to lower protein (LP) diets. This systematic review and meta-analysis aims to investigate the effects of HP versus LP diets on cardiometabolic risk factors in adults, using the totality of the current evidence from randomised controlled trials (RCTs).Methods: Systematic searches were conducted in electronic databases, up to November 2020. Random effects meta-analyses were conducted to pool the standardised mean differences (SMD) and 95% confidence intervals (CI). The main outcomes were weight loss, body mass index (BMI), waist circumference, fat mass, systolic and diastolic BP, total cholesterol, HDL-and LDL-cholesterol, triacylglycerol, fasting glucose and insulin, and glycated haemoglobin.Results: Fifty-seven articles reporting on 54 RCTs were included, involving 4344 participants (65% female, mean age: 46 (SD 10) years, mean BMI: 33 (SD 3) kg/m2), with a mean study duration of 18 weeks (range: 4 to 156 weeks). Compared to LP diets (range protein (E%):10-23%), HP diets (range protein (E%): 20-45%) led to more weight loss (SMD -0.13, 95% CI: -0.23, -0.03), greater reductions in fat mass (SMD -0.14, 95% CI: -0.24, -0.04), systolic BP (SMD -0.12, 95% CI: -0.21, -0.02), total cholesterol (SMD -0.11, 95% CI: -0.19, -0.02), triacylglycerol (SMD -0.22, 95% CI: -0.30, -0.14) and insulin (SMD -0.12, 95% CI: -0.22, -0.03). No significant differences were observed for the other outcomes.Conclusions: Higher protein diets showed small, but favourable effects on weight loss, fat mass loss, systolic blood pressure, some lipid outcomes and insulin, compared to lower protein diets.

KW - Faculty of Science

KW - Cardiometabolic

KW - Meta-analysis

KW - Protein diet

KW - Randomised controlled trial

KW - Systematic review

U2 - 10.1016/j.atherosclerosis.2021.05.011

DO - 10.1016/j.atherosclerosis.2021.05.011

M3 - Review

C2 - 34120735

VL - 328

SP - 124

EP - 135

JO - Journal of atherosclerosis research

JF - Journal of atherosclerosis research

SN - 1567-5688

ER -

ID: 272166244

Institut for Idræt og Ernæring