Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin

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Standard

Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin. / Zaharudin, Nazikussabah Binti; Stærk, Dan; Dragsted, Lars Ove.

I: Food Chemistry, Bind 270, 2019, s. 481-486.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Zaharudin, NB, Stærk, D & Dragsted, LO 2019, 'Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin', Food Chemistry, bind 270, s. 481-486. https://doi.org/10.1016/j.foodchem.2018.07.142

APA

Zaharudin, N. B., Stærk, D., & Dragsted, L. O. (2019). Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin. Food Chemistry, 270, 481-486. https://doi.org/10.1016/j.foodchem.2018.07.142

Vancouver

Zaharudin NB, Stærk D, Dragsted LO. Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin. Food Chemistry. 2019;270:481-486. https://doi.org/10.1016/j.foodchem.2018.07.142

Author

Zaharudin, Nazikussabah Binti ; Stærk, Dan ; Dragsted, Lars Ove. / Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin. I: Food Chemistry. 2019 ; Bind 270. s. 481-486.

Bibtex

@article{18e30f52a19c417c93066470b27395bf,
title = "Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin",
abstract = "A 5 mg/mL solution of water, methanol and acetone extracts of seaweeds were used for α-glucosidase inhibition assay hyphenated with high performance liquid chromatography-mass spectrometry (HPLC-HRMS). The results showed acetone extracts of Undaria pinnatifida has the strongest inhibitory effect against α-glucosidase activity with IC50 0.08 ± 0.002 mg/mL. The active compound found in Undaria pinnatifida was identified as fucoxanthin. Analytical standard sample of fucoxanthin significantly inhibited α-glucosidase with IC50 value 0.047 ± 0.001 mg/mL. An inhibition kinetics study indicates that fucoxanthin is showing mixed-type inhibition. These results suggest that Undaria pinnatifida has a potential to inhibit α-glucosidase and may be used as a bioactive food ingredient for glycaemic control.",
keywords = "Faculty of Science, Seaweed, Glycaemic control, Hyperglycaemia, α-Glucosidase, Fucoxanthin",
author = "Zaharudin, {Nazikussabah Binti} and Dan St{\ae}rk and Dragsted, {Lars Ove}",
note = "CURIS 2019 NEXS 001",
year = "2019",
doi = "10.1016/j.foodchem.2018.07.142",
language = "English",
volume = "270",
pages = "481--486",
journal = "Food Chemistry",
issn = "0308-8146",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin

AU - Zaharudin, Nazikussabah Binti

AU - Stærk, Dan

AU - Dragsted, Lars Ove

N1 - CURIS 2019 NEXS 001

PY - 2019

Y1 - 2019

N2 - A 5 mg/mL solution of water, methanol and acetone extracts of seaweeds were used for α-glucosidase inhibition assay hyphenated with high performance liquid chromatography-mass spectrometry (HPLC-HRMS). The results showed acetone extracts of Undaria pinnatifida has the strongest inhibitory effect against α-glucosidase activity with IC50 0.08 ± 0.002 mg/mL. The active compound found in Undaria pinnatifida was identified as fucoxanthin. Analytical standard sample of fucoxanthin significantly inhibited α-glucosidase with IC50 value 0.047 ± 0.001 mg/mL. An inhibition kinetics study indicates that fucoxanthin is showing mixed-type inhibition. These results suggest that Undaria pinnatifida has a potential to inhibit α-glucosidase and may be used as a bioactive food ingredient for glycaemic control.

AB - A 5 mg/mL solution of water, methanol and acetone extracts of seaweeds were used for α-glucosidase inhibition assay hyphenated with high performance liquid chromatography-mass spectrometry (HPLC-HRMS). The results showed acetone extracts of Undaria pinnatifida has the strongest inhibitory effect against α-glucosidase activity with IC50 0.08 ± 0.002 mg/mL. The active compound found in Undaria pinnatifida was identified as fucoxanthin. Analytical standard sample of fucoxanthin significantly inhibited α-glucosidase with IC50 value 0.047 ± 0.001 mg/mL. An inhibition kinetics study indicates that fucoxanthin is showing mixed-type inhibition. These results suggest that Undaria pinnatifida has a potential to inhibit α-glucosidase and may be used as a bioactive food ingredient for glycaemic control.

KW - Faculty of Science

KW - Seaweed

KW - Glycaemic control

KW - Hyperglycaemia

KW - α-Glucosidase

KW - Fucoxanthin

U2 - 10.1016/j.foodchem.2018.07.142

DO - 10.1016/j.foodchem.2018.07.142

M3 - Journal article

C2 - 30174076

VL - 270

SP - 481

EP - 486

JO - Food Chemistry

JF - Food Chemistry

SN - 0308-8146

ER -

ID: 201905367