Hematological adaptations to prolonged heat acclimation in endurance-trained males

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Hematological adaptations to prolonged heat acclimation in endurance-trained males. / Oberholzer, Laura; Siebenmann, Christoph; Mikkelsen, Jacob; Junge, Nicklas; Piil, Jacob Feder; Morris, Nathan Bradley; Goetze, Jens Peter; Lundby, Anne-Kathrine Meinild; Nybo, Lars; Lundby, Carsten.

I: Frontiers in Physiology, Bind 10, 1379, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Oberholzer, L, Siebenmann, C, Mikkelsen, J, Junge, N, Piil, JF, Morris, NB, Goetze, JP, Lundby, A-KM, Nybo, L & Lundby, C 2019, 'Hematological adaptations to prolonged heat acclimation in endurance-trained males', Frontiers in Physiology, bind 10, 1379. https://doi.org/10.3389/fphys.2019.01379

APA

Oberholzer, L., Siebenmann, C., Mikkelsen, J., Junge, N., Piil, J. F., Morris, N. B., ... Lundby, C. (2019). Hematological adaptations to prolonged heat acclimation in endurance-trained males. Frontiers in Physiology, 10, [1379]. https://doi.org/10.3389/fphys.2019.01379

Vancouver

Oberholzer L, Siebenmann C, Mikkelsen J, Junge N, Piil JF, Morris NB o.a. Hematological adaptations to prolonged heat acclimation in endurance-trained males. Frontiers in Physiology. 2019;10. 1379. https://doi.org/10.3389/fphys.2019.01379

Author

Oberholzer, Laura ; Siebenmann, Christoph ; Mikkelsen, Jacob ; Junge, Nicklas ; Piil, Jacob Feder ; Morris, Nathan Bradley ; Goetze, Jens Peter ; Lundby, Anne-Kathrine Meinild ; Nybo, Lars ; Lundby, Carsten. / Hematological adaptations to prolonged heat acclimation in endurance-trained males. I: Frontiers in Physiology. 2019 ; Bind 10.

Bibtex

@article{55246f5389f74fdb9c4ad7d2fa9f55cb,
title = "Hematological adaptations to prolonged heat acclimation in endurance-trained males",
abstract = "Heat acclimation is associated with plasma volume (PV) expansion that occurs within the first week of exposure. However, prolonged effects on hemoglobin mass (Hbmass) are unclear as intervention periods in previous studies have not allowed sufficient time for erythropoiesis to manifest. Therefore, Hbmass, intravascular volumes, and blood volume (BV)-regulating hormones were assessed with 5½ weeks of exercise-heat acclimation (HEAT) or matched training in cold conditions (CON) in 21 male cyclists [(mean ± SD) age: 38 ± 9 years, body weight: 80.4 ± 7.9 kg, VO2peak: 59.1 ± 5.2 ml/min/kg]. HEAT (n = 12) consisted of 1 h cycling at 60{\%} VO2peak in 40°C for 5 days/week in addition to regular training, whereas CON (n = 9) trained exclusively in cold conditions (<15°C). Before and after the intervention, Hbmass and intravascular volumes were assessed by carbon monoxide rebreathing, while reticulocyte count and BV-regulating hormones were measured before, after 2 weeks and post intervention. Total training volume during the intervention was similar (p = 0.282) between HEAT (509 ± 173 min/week) and CON (576 ± 143 min/week). PV increased (p = 0.004) in both groups, by 303 ± 345 ml in HEAT and 188 ± 286 ml in CON. There was also a main effect of time (p = 0.038) for Hbmass with +34 ± 36 g in HEAT and +2 ± 33 g in CON and a tendency toward a higher increase in Hbmass in HEAT compared to CON (time × group interaction: p = 0.061). The Hbmass changes were weakly correlated to alterations in PV (r = 0.493, p = 0.023). Reticulocyte count and BV-regulating hormones remained unchanged for both groups. In conclusion, Hbmass was slightly increased following prolonged training in the heat and although the mechanistic link remains to be revealed, the increase could represent a compensatory response in erythropoiesis secondary to PV expansion.",
keywords = "Faculty of Science, Hemoglobin mass, Blood volume, Critmeter, Hematocrit, Vasopressin, Erythropoietin",
author = "Laura Oberholzer and Christoph Siebenmann and Jacob Mikkelsen and Nicklas Junge and Piil, {Jacob Feder} and Morris, {Nathan Bradley} and Goetze, {Jens Peter} and Lundby, {Anne-Kathrine Meinild} and Lars Nybo and Carsten Lundby",
note = "Copyright {\circledC} 2019 Oberholzer, Siebenmann, Mikkelsen, Junge, Piil, Morris, Goetze, Siebenmann, Meinild Lundby, Nybo and Lundby.",
year = "2019",
doi = "10.3389/fphys.2019.01379",
language = "English",
volume = "10",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Hematological adaptations to prolonged heat acclimation in endurance-trained males

AU - Oberholzer, Laura

AU - Siebenmann, Christoph

AU - Mikkelsen, Jacob

AU - Junge, Nicklas

AU - Piil, Jacob Feder

AU - Morris, Nathan Bradley

AU - Goetze, Jens Peter

AU - Lundby, Anne-Kathrine Meinild

AU - Nybo, Lars

AU - Lundby, Carsten

N1 - Copyright © 2019 Oberholzer, Siebenmann, Mikkelsen, Junge, Piil, Morris, Goetze, Siebenmann, Meinild Lundby, Nybo and Lundby.

PY - 2019

Y1 - 2019

N2 - Heat acclimation is associated with plasma volume (PV) expansion that occurs within the first week of exposure. However, prolonged effects on hemoglobin mass (Hbmass) are unclear as intervention periods in previous studies have not allowed sufficient time for erythropoiesis to manifest. Therefore, Hbmass, intravascular volumes, and blood volume (BV)-regulating hormones were assessed with 5½ weeks of exercise-heat acclimation (HEAT) or matched training in cold conditions (CON) in 21 male cyclists [(mean ± SD) age: 38 ± 9 years, body weight: 80.4 ± 7.9 kg, VO2peak: 59.1 ± 5.2 ml/min/kg]. HEAT (n = 12) consisted of 1 h cycling at 60% VO2peak in 40°C for 5 days/week in addition to regular training, whereas CON (n = 9) trained exclusively in cold conditions (<15°C). Before and after the intervention, Hbmass and intravascular volumes were assessed by carbon monoxide rebreathing, while reticulocyte count and BV-regulating hormones were measured before, after 2 weeks and post intervention. Total training volume during the intervention was similar (p = 0.282) between HEAT (509 ± 173 min/week) and CON (576 ± 143 min/week). PV increased (p = 0.004) in both groups, by 303 ± 345 ml in HEAT and 188 ± 286 ml in CON. There was also a main effect of time (p = 0.038) for Hbmass with +34 ± 36 g in HEAT and +2 ± 33 g in CON and a tendency toward a higher increase in Hbmass in HEAT compared to CON (time × group interaction: p = 0.061). The Hbmass changes were weakly correlated to alterations in PV (r = 0.493, p = 0.023). Reticulocyte count and BV-regulating hormones remained unchanged for both groups. In conclusion, Hbmass was slightly increased following prolonged training in the heat and although the mechanistic link remains to be revealed, the increase could represent a compensatory response in erythropoiesis secondary to PV expansion.

AB - Heat acclimation is associated with plasma volume (PV) expansion that occurs within the first week of exposure. However, prolonged effects on hemoglobin mass (Hbmass) are unclear as intervention periods in previous studies have not allowed sufficient time for erythropoiesis to manifest. Therefore, Hbmass, intravascular volumes, and blood volume (BV)-regulating hormones were assessed with 5½ weeks of exercise-heat acclimation (HEAT) or matched training in cold conditions (CON) in 21 male cyclists [(mean ± SD) age: 38 ± 9 years, body weight: 80.4 ± 7.9 kg, VO2peak: 59.1 ± 5.2 ml/min/kg]. HEAT (n = 12) consisted of 1 h cycling at 60% VO2peak in 40°C for 5 days/week in addition to regular training, whereas CON (n = 9) trained exclusively in cold conditions (<15°C). Before and after the intervention, Hbmass and intravascular volumes were assessed by carbon monoxide rebreathing, while reticulocyte count and BV-regulating hormones were measured before, after 2 weeks and post intervention. Total training volume during the intervention was similar (p = 0.282) between HEAT (509 ± 173 min/week) and CON (576 ± 143 min/week). PV increased (p = 0.004) in both groups, by 303 ± 345 ml in HEAT and 188 ± 286 ml in CON. There was also a main effect of time (p = 0.038) for Hbmass with +34 ± 36 g in HEAT and +2 ± 33 g in CON and a tendency toward a higher increase in Hbmass in HEAT compared to CON (time × group interaction: p = 0.061). The Hbmass changes were weakly correlated to alterations in PV (r = 0.493, p = 0.023). Reticulocyte count and BV-regulating hormones remained unchanged for both groups. In conclusion, Hbmass was slightly increased following prolonged training in the heat and although the mechanistic link remains to be revealed, the increase could represent a compensatory response in erythropoiesis secondary to PV expansion.

KW - Faculty of Science

KW - Hemoglobin mass

KW - Blood volume

KW - Critmeter

KW - Hematocrit

KW - Vasopressin

KW - Erythropoietin

U2 - 10.3389/fphys.2019.01379

DO - 10.3389/fphys.2019.01379

M3 - Journal article

C2 - 31749713

VL - 10

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 1379

ER -

ID: 230563154