Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans

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Standard

Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans. / Nordsborg, Nikolai; Ovesen, Jakob; Thomassen, Martin; Zangenberg, Mathias; Jøns, Christian; Iaia, F. Marcello; Nielsen, Jens Jung; Bangsbo, Jens.

I: Journal of Physiology, Bind 586, Nr. 5, 2008, s. 1447-1459.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Nordsborg, N, Ovesen, J, Thomassen, M, Zangenberg, M, Jøns, C, Iaia, FM, Nielsen, JJ & Bangsbo, J 2008, 'Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans', Journal of Physiology, bind 586, nr. 5, s. 1447-1459. https://doi.org/10.1113/jphysiol.2007.143073

APA

Nordsborg, N., Ovesen, J., Thomassen, M., Zangenberg, M., Jøns, C., Iaia, F. M., Nielsen, J. J., & Bangsbo, J. (2008). Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans. Journal of Physiology, 586(5), 1447-1459. https://doi.org/10.1113/jphysiol.2007.143073

Vancouver

Nordsborg N, Ovesen J, Thomassen M, Zangenberg M, Jøns C, Iaia FM o.a. Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans. Journal of Physiology. 2008;586(5):1447-1459. https://doi.org/10.1113/jphysiol.2007.143073

Author

Nordsborg, Nikolai ; Ovesen, Jakob ; Thomassen, Martin ; Zangenberg, Mathias ; Jøns, Christian ; Iaia, F. Marcello ; Nielsen, Jens Jung ; Bangsbo, Jens. / Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans. I: Journal of Physiology. 2008 ; Bind 586, Nr. 5. s. 1447-1459.

Bibtex

@article{683a9730eeaf11dcbee902004c4f4f50,
title = "Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans",
abstract = "The effect of dexamethasone on Na(+),K(+) pump subunit expression and muscle exchange of K(+) during exercise in humans was investigated. Nine healthy male subjects completed a randomized double blind placebo controlled protocol, with ingestion of dexamethasone (Dex: 2 x 2 mg per day) or placebo (Pla) for 5 days. Na(+),K(+) pump catalytic alpha1 and alpha2 subunit expression was approximately 17% higher (P < 0.05) and the structural beta1 and beta2 subunit expression was approximately 6-8% higher (P < 0.05) after Dex compared with Pla. During one-legged knee-extension for 10 min at low intensity (LI; 18.6 +/- 1.0 W), two moderate intensity (51.7 +/- 2.4 W) exercise bouts (MI(1): 5 min; 2 min recovery; MI(2): exhaustive) and two high-intensity (71.7 +/- 2.5 W) exercise bouts (HI(1): 1 min 40 s; 2 min recovery; HI(2): exhaustive), femoral venous K(+) was lower (P < 0.05) in Dex compared with Pla. Thigh K(+) release was lower (P < 0.05) in Dex compared with Pla in LI and MI, but not in HI. Time to exhaustion in MI(2) tended to improve (393 +/- 50 s versus 294 +/- 41 s; P = 0.07) in Dex compared with Pla, whereas no difference was detected in HI(2) (106 +/- 10 s versus 108 +/- 9 s). The results indicate that an increased Na(+),K(+) pump expression per se is of importance for thigh K(+) reuptake at the onset of low and moderate intensity exercise, but less important during high intensity exercise.",
author = "Nikolai Nordsborg and Jakob Ovesen and Martin Thomassen and Mathias Zangenberg and Christian J{\o}ns and Iaia, {F. Marcello} and Nielsen, {Jens Jung} and Jens Bangsbo",
note = "CURIS 2008 5200 006",
year = "2008",
doi = "10.1113/jphysiol.2007.143073",
language = "English",
volume = "586",
pages = "1447--1459",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans

AU - Nordsborg, Nikolai

AU - Ovesen, Jakob

AU - Thomassen, Martin

AU - Zangenberg, Mathias

AU - Jøns, Christian

AU - Iaia, F. Marcello

AU - Nielsen, Jens Jung

AU - Bangsbo, Jens

N1 - CURIS 2008 5200 006

PY - 2008

Y1 - 2008

N2 - The effect of dexamethasone on Na(+),K(+) pump subunit expression and muscle exchange of K(+) during exercise in humans was investigated. Nine healthy male subjects completed a randomized double blind placebo controlled protocol, with ingestion of dexamethasone (Dex: 2 x 2 mg per day) or placebo (Pla) for 5 days. Na(+),K(+) pump catalytic alpha1 and alpha2 subunit expression was approximately 17% higher (P < 0.05) and the structural beta1 and beta2 subunit expression was approximately 6-8% higher (P < 0.05) after Dex compared with Pla. During one-legged knee-extension for 10 min at low intensity (LI; 18.6 +/- 1.0 W), two moderate intensity (51.7 +/- 2.4 W) exercise bouts (MI(1): 5 min; 2 min recovery; MI(2): exhaustive) and two high-intensity (71.7 +/- 2.5 W) exercise bouts (HI(1): 1 min 40 s; 2 min recovery; HI(2): exhaustive), femoral venous K(+) was lower (P < 0.05) in Dex compared with Pla. Thigh K(+) release was lower (P < 0.05) in Dex compared with Pla in LI and MI, but not in HI. Time to exhaustion in MI(2) tended to improve (393 +/- 50 s versus 294 +/- 41 s; P = 0.07) in Dex compared with Pla, whereas no difference was detected in HI(2) (106 +/- 10 s versus 108 +/- 9 s). The results indicate that an increased Na(+),K(+) pump expression per se is of importance for thigh K(+) reuptake at the onset of low and moderate intensity exercise, but less important during high intensity exercise.

AB - The effect of dexamethasone on Na(+),K(+) pump subunit expression and muscle exchange of K(+) during exercise in humans was investigated. Nine healthy male subjects completed a randomized double blind placebo controlled protocol, with ingestion of dexamethasone (Dex: 2 x 2 mg per day) or placebo (Pla) for 5 days. Na(+),K(+) pump catalytic alpha1 and alpha2 subunit expression was approximately 17% higher (P < 0.05) and the structural beta1 and beta2 subunit expression was approximately 6-8% higher (P < 0.05) after Dex compared with Pla. During one-legged knee-extension for 10 min at low intensity (LI; 18.6 +/- 1.0 W), two moderate intensity (51.7 +/- 2.4 W) exercise bouts (MI(1): 5 min; 2 min recovery; MI(2): exhaustive) and two high-intensity (71.7 +/- 2.5 W) exercise bouts (HI(1): 1 min 40 s; 2 min recovery; HI(2): exhaustive), femoral venous K(+) was lower (P < 0.05) in Dex compared with Pla. Thigh K(+) release was lower (P < 0.05) in Dex compared with Pla in LI and MI, but not in HI. Time to exhaustion in MI(2) tended to improve (393 +/- 50 s versus 294 +/- 41 s; P = 0.07) in Dex compared with Pla, whereas no difference was detected in HI(2) (106 +/- 10 s versus 108 +/- 9 s). The results indicate that an increased Na(+),K(+) pump expression per se is of importance for thigh K(+) reuptake at the onset of low and moderate intensity exercise, but less important during high intensity exercise.

U2 - 10.1113/jphysiol.2007.143073

DO - 10.1113/jphysiol.2007.143073

M3 - Journal article

C2 - 18174214

VL - 586

SP - 1447

EP - 1459

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 5

ER -

ID: 3090253