Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change: results from a randomized 2-stage dietary intervention trial

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Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change : results from a randomized 2-stage dietary intervention trial. / Turicchi, Jake; O'Driscoll, Ruairi; Finlayson, Graham; Duarte, Cristiana; Hopkins, Mark; Martins, Nuno; Michalowska, Joanna; Larsen, Thomas Meinert; van Baak, Marleen A; Astrup, Arne; Stubbs, R James.

I: American Journal of Clinical Nutrition, Bind 111, Nr. 3, 2020, s. 536-544.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Turicchi, J, O'Driscoll, R, Finlayson, G, Duarte, C, Hopkins, M, Martins, N, Michalowska, J, Larsen, TM, van Baak, MA, Astrup, A & Stubbs, RJ 2020, 'Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change: results from a randomized 2-stage dietary intervention trial', American Journal of Clinical Nutrition, bind 111, nr. 3, s. 536-544. https://doi.org/10.1093/ajcn/nqz331

APA

Turicchi, J., O'Driscoll, R., Finlayson, G., Duarte, C., Hopkins, M., Martins, N., ... Stubbs, R. J. (2020). Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change: results from a randomized 2-stage dietary intervention trial. American Journal of Clinical Nutrition, 111(3), 536-544. https://doi.org/10.1093/ajcn/nqz331

Vancouver

Turicchi J, O'Driscoll R, Finlayson G, Duarte C, Hopkins M, Martins N o.a. Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change: results from a randomized 2-stage dietary intervention trial. American Journal of Clinical Nutrition. 2020;111(3):536-544. https://doi.org/10.1093/ajcn/nqz331

Author

Turicchi, Jake ; O'Driscoll, Ruairi ; Finlayson, Graham ; Duarte, Cristiana ; Hopkins, Mark ; Martins, Nuno ; Michalowska, Joanna ; Larsen, Thomas Meinert ; van Baak, Marleen A ; Astrup, Arne ; Stubbs, R James. / Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change : results from a randomized 2-stage dietary intervention trial. I: American Journal of Clinical Nutrition. 2020 ; Bind 111, Nr. 3. s. 536-544.

Bibtex

@article{d9625eb0213a4cc7b38fa74f4bd0dc79,
title = "Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change: results from a randomized 2-stage dietary intervention trial",
abstract = "Background: Dynamic changes in body composition which occur during weight loss may have an influential role on subsequent energy balance behaviors and weight.Objectives: The aim of this article is to consider the effect of proportionate changes in body composition during weight loss on subsequent changes in appetite and weight outcomes at 26 wk in individuals engaged in a weight loss maintenance intervention.Methods: A subgroup of the Diet, Obesity, and Genes (DiOGenes) study (n = 209) was recruited from 3 European countries. Participants underwent an 8-wk low-calorie diet (LCD) resulting in ≥8{\%} body weight loss, during which changes in body composition (by DXA) and appetite (by visual analog scale appetite perceptions in response to a fixed test meal) were measured. Participants were randomly assigned into 5 weight loss maintenance diets based on protein and glycemic index content and followed up for 26 wk. We investigated associations between proportionate fat-free mass (FFM) loss ({\%}FFML) during weight loss and 1) weight outcomes at 26 wk and 2) changes in appetite perceptions.Results: During the LCD, participants lost a mean ± SD of 11.2 ± 3.5 kg, of which 30.4{\%} was FFM. After adjustment, there was a tendency for {\%}FFML to predict weight regain in the whole group (β: 0.041; 95{\%} CI: -0.001, 0.08; P = 0.055), which was significant in men (β: 0.09; 95{\%} CI: 0.02, 0.15; P = 0.009) but not women (β: 0.01; 95{\%} CI: -0.04, 0.07; P = 0.69). Associations between {\%}FFML and change in appetite perceptions during weight loss were inconsistent. The strongest observations were in men for hunger (r = 0.69, P = 0.002) and desire to eat (r = 0.61, P = 0.009), with some tendencies in the whole group and no associations in women.Conclusions: Our results suggest that composition of weight loss may have functional importance for energy balance regulation, with greater losses of FFM potentially being associated with increased weight regain and appetite. This trial was registered at clinicaltrials.gov as NCT00390637.",
keywords = "Faculty of Science, Fat-free mass, Fat mass, Body composition, Appetite, Weight loss, Weight regain, Obesity, Low-calorie diet, DiOGenes",
author = "Jake Turicchi and Ruairi O'Driscoll and Graham Finlayson and Cristiana Duarte and Mark Hopkins and Nuno Martins and Joanna Michalowska and Larsen, {Thomas Meinert} and {van Baak}, {Marleen A} and Arne Astrup and Stubbs, {R James}",
note = "Copyright {\circledC} The Author(s) 2020.",
year = "2020",
doi = "10.1093/ajcn/nqz331",
language = "English",
volume = "111",
pages = "536--544",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

RIS

TY - JOUR

T1 - Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change

T2 - results from a randomized 2-stage dietary intervention trial

AU - Turicchi, Jake

AU - O'Driscoll, Ruairi

AU - Finlayson, Graham

AU - Duarte, Cristiana

AU - Hopkins, Mark

AU - Martins, Nuno

AU - Michalowska, Joanna

AU - Larsen, Thomas Meinert

AU - van Baak, Marleen A

AU - Astrup, Arne

AU - Stubbs, R James

N1 - Copyright © The Author(s) 2020.

PY - 2020

Y1 - 2020

N2 - Background: Dynamic changes in body composition which occur during weight loss may have an influential role on subsequent energy balance behaviors and weight.Objectives: The aim of this article is to consider the effect of proportionate changes in body composition during weight loss on subsequent changes in appetite and weight outcomes at 26 wk in individuals engaged in a weight loss maintenance intervention.Methods: A subgroup of the Diet, Obesity, and Genes (DiOGenes) study (n = 209) was recruited from 3 European countries. Participants underwent an 8-wk low-calorie diet (LCD) resulting in ≥8% body weight loss, during which changes in body composition (by DXA) and appetite (by visual analog scale appetite perceptions in response to a fixed test meal) were measured. Participants were randomly assigned into 5 weight loss maintenance diets based on protein and glycemic index content and followed up for 26 wk. We investigated associations between proportionate fat-free mass (FFM) loss (%FFML) during weight loss and 1) weight outcomes at 26 wk and 2) changes in appetite perceptions.Results: During the LCD, participants lost a mean ± SD of 11.2 ± 3.5 kg, of which 30.4% was FFM. After adjustment, there was a tendency for %FFML to predict weight regain in the whole group (β: 0.041; 95% CI: -0.001, 0.08; P = 0.055), which was significant in men (β: 0.09; 95% CI: 0.02, 0.15; P = 0.009) but not women (β: 0.01; 95% CI: -0.04, 0.07; P = 0.69). Associations between %FFML and change in appetite perceptions during weight loss were inconsistent. The strongest observations were in men for hunger (r = 0.69, P = 0.002) and desire to eat (r = 0.61, P = 0.009), with some tendencies in the whole group and no associations in women.Conclusions: Our results suggest that composition of weight loss may have functional importance for energy balance regulation, with greater losses of FFM potentially being associated with increased weight regain and appetite. This trial was registered at clinicaltrials.gov as NCT00390637.

AB - Background: Dynamic changes in body composition which occur during weight loss may have an influential role on subsequent energy balance behaviors and weight.Objectives: The aim of this article is to consider the effect of proportionate changes in body composition during weight loss on subsequent changes in appetite and weight outcomes at 26 wk in individuals engaged in a weight loss maintenance intervention.Methods: A subgroup of the Diet, Obesity, and Genes (DiOGenes) study (n = 209) was recruited from 3 European countries. Participants underwent an 8-wk low-calorie diet (LCD) resulting in ≥8% body weight loss, during which changes in body composition (by DXA) and appetite (by visual analog scale appetite perceptions in response to a fixed test meal) were measured. Participants were randomly assigned into 5 weight loss maintenance diets based on protein and glycemic index content and followed up for 26 wk. We investigated associations between proportionate fat-free mass (FFM) loss (%FFML) during weight loss and 1) weight outcomes at 26 wk and 2) changes in appetite perceptions.Results: During the LCD, participants lost a mean ± SD of 11.2 ± 3.5 kg, of which 30.4% was FFM. After adjustment, there was a tendency for %FFML to predict weight regain in the whole group (β: 0.041; 95% CI: -0.001, 0.08; P = 0.055), which was significant in men (β: 0.09; 95% CI: 0.02, 0.15; P = 0.009) but not women (β: 0.01; 95% CI: -0.04, 0.07; P = 0.69). Associations between %FFML and change in appetite perceptions during weight loss were inconsistent. The strongest observations were in men for hunger (r = 0.69, P = 0.002) and desire to eat (r = 0.61, P = 0.009), with some tendencies in the whole group and no associations in women.Conclusions: Our results suggest that composition of weight loss may have functional importance for energy balance regulation, with greater losses of FFM potentially being associated with increased weight regain and appetite. This trial was registered at clinicaltrials.gov as NCT00390637.

KW - Faculty of Science

KW - Fat-free mass

KW - Fat mass

KW - Body composition

KW - Appetite

KW - Weight loss

KW - Weight regain

KW - Obesity

KW - Low-calorie diet

KW - DiOGenes

U2 - 10.1093/ajcn/nqz331

DO - 10.1093/ajcn/nqz331

M3 - Journal article

C2 - 31950141

VL - 111

SP - 536

EP - 544

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -

ID: 237659193