Museums are in a unique position to engage the public in conversations about science topics that matter. However, when we attempt to systematically study the representation and dissemination of science in museums, we are confounded by the numerous and diverse conditions and constraints that influence those processes. As a response, we adapt a framework from the field of science didactics, the framework of didactic co-determination, to the museum context. We illustrate how the framework can be applied to a case of exhibit development to understand the influences that shape the final product. We then offer our perspectives on the framework, and suggest how its utility may go beyond the local application described here.