Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner

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Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner. / Roumans, Nadia J T; Vink, Roel G; Gielen, Marij; Zeegers, Maurice P; Holst, Claus; Wang, Ping; Astrup, Arne; Saris, Wim H; Valsesia, Armand; Hager, Jörg; van Baak, Marleen A; Mariman, Edwin C M.

I: Genes & Nutrition, Bind 10, Nr. 6, 56, 2015.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Roumans, NJT, Vink, RG, Gielen, M, Zeegers, MP, Holst, C, Wang, P, Astrup, A, Saris, WH, Valsesia, A, Hager, J, van Baak, MA & Mariman, ECM 2015, 'Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner', Genes & Nutrition, bind 10, nr. 6, 56. https://doi.org/10.1007/s12263-015-0506-y

APA

Roumans, N. J. T., Vink, R. G., Gielen, M., Zeegers, M. P., Holst, C., Wang, P., ... Mariman, E. C. M. (2015). Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner. Genes & Nutrition, 10(6), [56]. https://doi.org/10.1007/s12263-015-0506-y

Vancouver

Roumans NJT, Vink RG, Gielen M, Zeegers MP, Holst C, Wang P o.a. Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner. Genes & Nutrition. 2015;10(6). 56. https://doi.org/10.1007/s12263-015-0506-y

Author

Roumans, Nadia J T ; Vink, Roel G ; Gielen, Marij ; Zeegers, Maurice P ; Holst, Claus ; Wang, Ping ; Astrup, Arne ; Saris, Wim H ; Valsesia, Armand ; Hager, Jörg ; van Baak, Marleen A ; Mariman, Edwin C M. / Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner. I: Genes & Nutrition. 2015 ; Bind 10, Nr. 6.

Bibtex

@article{c1093411e8b2442f81e11b21c76abe57,
title = "Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner",
abstract = "The extracellular matrix (ECM) of adipocytes is important for body weight regulation. Here, we investigated whether genetic variation in ECM-related genes is associated with weight regain among participants of the European DiOGenes study. Overweight and obese subjects (n = 469, 310 females, 159 males) were on an 8-week low-calorie diet with a 6-month follow-up. Body weight was measured before and after the diet, and after follow-up. Weight maintenance scores (WMS, regained weight as percentage of lost weight) were calculated based on the weight data. Genotype data were retrieved for 2903 SNPs corresponding to 124 ECM-related genes. Regression analyses provided us with six significant SNPs associated with the WMS in males: 3 SNPs in the POSTN gene and a SNP in the LAMB1, COL23A1, and FBLN5 genes. For females, 1 SNP was found in the FN1 gene. The risk of weight regain was increased by: the C/C genotype for POSTN in a co-dominant model (OR 8.25, 95 {\%} CI 2.85-23.88) and the T/C-C/C genotype in a dominant model (OR 4.88, 95 {\%} CI 2.35-10.16); the A/A genotype for LAMB1 both in a co-dominant model (OR 18.43, 95 {\%} CI 2.35-144.63) and in a recessive model (OR 16.36, 95 {\%} CI 2.14-124.9); the G/A genotype for COL23A1 in a co-dominant model (OR 3.94, 95 {\%} CI 1.28-12.10), or the A-allele in a dominant model (OR 2.86, 95 {\%} CI 1.10-7.49); the A/A genotype for FBLN5 in a co-dominant model (OR 13.00, 95 {\%} CI 1.61-104.81); and the A/A genotype for FN1 in a recessive model (OR 2.81, 95 {\%} CI 1.40-5.63). Concluding, variants of ECM genes are associated with weight regain after weight loss in a sex-specific manner.",
author = "Roumans, {Nadia J T} and Vink, {Roel G} and Marij Gielen and Zeegers, {Maurice P} and Claus Holst and Ping Wang and Arne Astrup and Saris, {Wim H} and Armand Valsesia and J{\"o}rg Hager and {van Baak}, {Marleen A} and Mariman, {Edwin C M}",
note = "CURIS 2015 NEXS 342",
year = "2015",
doi = "10.1007/s12263-015-0506-y",
language = "English",
volume = "10",
journal = "Genes & Nutrition",
issn = "1555-8932",
publisher = "BioMed Central Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner

AU - Roumans, Nadia J T

AU - Vink, Roel G

AU - Gielen, Marij

AU - Zeegers, Maurice P

AU - Holst, Claus

AU - Wang, Ping

AU - Astrup, Arne

AU - Saris, Wim H

AU - Valsesia, Armand

AU - Hager, Jörg

AU - van Baak, Marleen A

AU - Mariman, Edwin C M

N1 - CURIS 2015 NEXS 342

PY - 2015

Y1 - 2015

N2 - The extracellular matrix (ECM) of adipocytes is important for body weight regulation. Here, we investigated whether genetic variation in ECM-related genes is associated with weight regain among participants of the European DiOGenes study. Overweight and obese subjects (n = 469, 310 females, 159 males) were on an 8-week low-calorie diet with a 6-month follow-up. Body weight was measured before and after the diet, and after follow-up. Weight maintenance scores (WMS, regained weight as percentage of lost weight) were calculated based on the weight data. Genotype data were retrieved for 2903 SNPs corresponding to 124 ECM-related genes. Regression analyses provided us with six significant SNPs associated with the WMS in males: 3 SNPs in the POSTN gene and a SNP in the LAMB1, COL23A1, and FBLN5 genes. For females, 1 SNP was found in the FN1 gene. The risk of weight regain was increased by: the C/C genotype for POSTN in a co-dominant model (OR 8.25, 95 % CI 2.85-23.88) and the T/C-C/C genotype in a dominant model (OR 4.88, 95 % CI 2.35-10.16); the A/A genotype for LAMB1 both in a co-dominant model (OR 18.43, 95 % CI 2.35-144.63) and in a recessive model (OR 16.36, 95 % CI 2.14-124.9); the G/A genotype for COL23A1 in a co-dominant model (OR 3.94, 95 % CI 1.28-12.10), or the A-allele in a dominant model (OR 2.86, 95 % CI 1.10-7.49); the A/A genotype for FBLN5 in a co-dominant model (OR 13.00, 95 % CI 1.61-104.81); and the A/A genotype for FN1 in a recessive model (OR 2.81, 95 % CI 1.40-5.63). Concluding, variants of ECM genes are associated with weight regain after weight loss in a sex-specific manner.

AB - The extracellular matrix (ECM) of adipocytes is important for body weight regulation. Here, we investigated whether genetic variation in ECM-related genes is associated with weight regain among participants of the European DiOGenes study. Overweight and obese subjects (n = 469, 310 females, 159 males) were on an 8-week low-calorie diet with a 6-month follow-up. Body weight was measured before and after the diet, and after follow-up. Weight maintenance scores (WMS, regained weight as percentage of lost weight) were calculated based on the weight data. Genotype data were retrieved for 2903 SNPs corresponding to 124 ECM-related genes. Regression analyses provided us with six significant SNPs associated with the WMS in males: 3 SNPs in the POSTN gene and a SNP in the LAMB1, COL23A1, and FBLN5 genes. For females, 1 SNP was found in the FN1 gene. The risk of weight regain was increased by: the C/C genotype for POSTN in a co-dominant model (OR 8.25, 95 % CI 2.85-23.88) and the T/C-C/C genotype in a dominant model (OR 4.88, 95 % CI 2.35-10.16); the A/A genotype for LAMB1 both in a co-dominant model (OR 18.43, 95 % CI 2.35-144.63) and in a recessive model (OR 16.36, 95 % CI 2.14-124.9); the G/A genotype for COL23A1 in a co-dominant model (OR 3.94, 95 % CI 1.28-12.10), or the A-allele in a dominant model (OR 2.86, 95 % CI 1.10-7.49); the A/A genotype for FBLN5 in a co-dominant model (OR 13.00, 95 % CI 1.61-104.81); and the A/A genotype for FN1 in a recessive model (OR 2.81, 95 % CI 1.40-5.63). Concluding, variants of ECM genes are associated with weight regain after weight loss in a sex-specific manner.

U2 - 10.1007/s12263-015-0506-y

DO - 10.1007/s12263-015-0506-y

M3 - Journal article

C2 - 26584808

VL - 10

JO - Genes & Nutrition

JF - Genes & Nutrition

SN - 1555-8932

IS - 6

M1 - 56

ER -

ID: 156372113