The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme: A PREVIEW sub-study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme : A PREVIEW sub-study. / Møller, Grith; Andersen, Jens Rikardt; Jalo, Elli; Ritz, Christian; Brand-Miller, J; Larsen, Thomas Meinert; Silvestre, Marta P; Fogelholm, M; Poppitt, Sally D; Raben, Anne; Dragsted, Lars Ove.

I: European Journal of Nutrition, Bind 59, Nr. 4, 2020, s. 1517-1527.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Møller, G, Andersen, JR, Jalo, E, Ritz, C, Brand-Miller, J, Larsen, TM, Silvestre, MP, Fogelholm, M, Poppitt, SD, Raben, A & Dragsted, LO 2020, 'The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme: A PREVIEW sub-study', European Journal of Nutrition, bind 59, nr. 4, s. 1517-1527. https://doi.org/10.1007/s00394-019-02008-2

APA

Møller, G., Andersen, J. R., Jalo, E., Ritz, C., Brand-Miller, J., Larsen, T. M., ... Dragsted, L. O. (2020). The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme: A PREVIEW sub-study. European Journal of Nutrition, 59(4), 1517-1527. https://doi.org/10.1007/s00394-019-02008-2

Vancouver

Møller G, Andersen JR, Jalo E, Ritz C, Brand-Miller J, Larsen TM o.a. The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme: A PREVIEW sub-study. European Journal of Nutrition. 2020;59(4):1517-1527. https://doi.org/10.1007/s00394-019-02008-2

Author

Møller, Grith ; Andersen, Jens Rikardt ; Jalo, Elli ; Ritz, Christian ; Brand-Miller, J ; Larsen, Thomas Meinert ; Silvestre, Marta P ; Fogelholm, M ; Poppitt, Sally D ; Raben, Anne ; Dragsted, Lars Ove. / The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme : A PREVIEW sub-study. I: European Journal of Nutrition. 2020 ; Bind 59, Nr. 4. s. 1517-1527.

Bibtex

@article{3b00ac0fe35c41c0ae3a23e0f8bb0702,
title = "The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme: A PREVIEW sub-study",
abstract = "Purpose: Diets with increased protein content are popular strategies for body weight regulation, but the effect of such diets for the colonic luminal environment is unclear. We aimed to investigate the associations between putative colorectal cancerrelated markers and total protein intake, plant and animal proteins, and protein from red and processed meat in pre-diabeticadults (> 25 years).Methods: Analyses were based on clinical and dietary assessments at baseline and after 1 year of intervention. Protein intake was assessed from 4-day dietary records. Putative colorectal cancer-related markers identified from 24-h faecal samples collected over three consecutive days were: concentration of short-chain fatty acids, phenols, ammonia, and pH.Results: In total, 79 participants were included in the analyses. We found a positive association between change in total protein intake (slope: 74.72 ± 28.84 μmol per g faeces/E{\%}, p = 0.01), including animal protein intake (slope: 87.63 ± 32.04 μmol per g faeces/E{\%}, p = 0.009), and change in faecal ammonia concentration. For change in ammonia, there was a dose–response trend from the most negative (lowest tertile) to the most positive (highest tertile) association (p = 0.01): in the high tertile, a change in intake of red meat was positively associated with an increase in ammonia excretion (slope: 2.0 ± 0.5 μmol per gfaeces/g/day, p < 0.001), whereas no such association was found in the low and medium tertile groups.Conclusion: Increases in total and animal protein intakes were associated with higher excretion of ammonia in faeces after 1 year in overweight pre-diabetic adults undertaking a weight-loss intervention. An increase in total or relative protein intake, or in the ratio of animal to plant protein, was not associated with an increase in faeces of any of the other putative colorectal cancer risk markers.Trial registration: ClinicalTrials.gov Identifier: NCT01777893.",
keywords = "Faculty of Science, Dietary protein, Faecal, SCFA, pH, Ammonia, Phenols",
author = "Grith M{\o}ller and Andersen, {Jens Rikardt} and Elli Jalo and Christian Ritz and J Brand-Miller and Larsen, {Thomas Meinert} and Silvestre, {Marta P} and M Fogelholm and Poppitt, {Sally D} and Anne Raben and Dragsted, {Lars Ove}",
note = "CURIS 2020 NEXS 152",
year = "2020",
doi = "10.1007/s00394-019-02008-2",
language = "English",
volume = "59",
pages = "1517--1527",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "Springer Medizin",
number = "4",

}

RIS

TY - JOUR

T1 - The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme

T2 - A PREVIEW sub-study

AU - Møller, Grith

AU - Andersen, Jens Rikardt

AU - Jalo, Elli

AU - Ritz, Christian

AU - Brand-Miller, J

AU - Larsen, Thomas Meinert

AU - Silvestre, Marta P

AU - Fogelholm, M

AU - Poppitt, Sally D

AU - Raben, Anne

AU - Dragsted, Lars Ove

N1 - CURIS 2020 NEXS 152

PY - 2020

Y1 - 2020

N2 - Purpose: Diets with increased protein content are popular strategies for body weight regulation, but the effect of such diets for the colonic luminal environment is unclear. We aimed to investigate the associations between putative colorectal cancerrelated markers and total protein intake, plant and animal proteins, and protein from red and processed meat in pre-diabeticadults (> 25 years).Methods: Analyses were based on clinical and dietary assessments at baseline and after 1 year of intervention. Protein intake was assessed from 4-day dietary records. Putative colorectal cancer-related markers identified from 24-h faecal samples collected over three consecutive days were: concentration of short-chain fatty acids, phenols, ammonia, and pH.Results: In total, 79 participants were included in the analyses. We found a positive association between change in total protein intake (slope: 74.72 ± 28.84 μmol per g faeces/E%, p = 0.01), including animal protein intake (slope: 87.63 ± 32.04 μmol per g faeces/E%, p = 0.009), and change in faecal ammonia concentration. For change in ammonia, there was a dose–response trend from the most negative (lowest tertile) to the most positive (highest tertile) association (p = 0.01): in the high tertile, a change in intake of red meat was positively associated with an increase in ammonia excretion (slope: 2.0 ± 0.5 μmol per gfaeces/g/day, p < 0.001), whereas no such association was found in the low and medium tertile groups.Conclusion: Increases in total and animal protein intakes were associated with higher excretion of ammonia in faeces after 1 year in overweight pre-diabetic adults undertaking a weight-loss intervention. An increase in total or relative protein intake, or in the ratio of animal to plant protein, was not associated with an increase in faeces of any of the other putative colorectal cancer risk markers.Trial registration: ClinicalTrials.gov Identifier: NCT01777893.

AB - Purpose: Diets with increased protein content are popular strategies for body weight regulation, but the effect of such diets for the colonic luminal environment is unclear. We aimed to investigate the associations between putative colorectal cancerrelated markers and total protein intake, plant and animal proteins, and protein from red and processed meat in pre-diabeticadults (> 25 years).Methods: Analyses were based on clinical and dietary assessments at baseline and after 1 year of intervention. Protein intake was assessed from 4-day dietary records. Putative colorectal cancer-related markers identified from 24-h faecal samples collected over three consecutive days were: concentration of short-chain fatty acids, phenols, ammonia, and pH.Results: In total, 79 participants were included in the analyses. We found a positive association between change in total protein intake (slope: 74.72 ± 28.84 μmol per g faeces/E%, p = 0.01), including animal protein intake (slope: 87.63 ± 32.04 μmol per g faeces/E%, p = 0.009), and change in faecal ammonia concentration. For change in ammonia, there was a dose–response trend from the most negative (lowest tertile) to the most positive (highest tertile) association (p = 0.01): in the high tertile, a change in intake of red meat was positively associated with an increase in ammonia excretion (slope: 2.0 ± 0.5 μmol per gfaeces/g/day, p < 0.001), whereas no such association was found in the low and medium tertile groups.Conclusion: Increases in total and animal protein intakes were associated with higher excretion of ammonia in faeces after 1 year in overweight pre-diabetic adults undertaking a weight-loss intervention. An increase in total or relative protein intake, or in the ratio of animal to plant protein, was not associated with an increase in faeces of any of the other putative colorectal cancer risk markers.Trial registration: ClinicalTrials.gov Identifier: NCT01777893.

KW - Faculty of Science

KW - Dietary protein

KW - Faecal

KW - SCFA

KW - pH

KW - Ammonia

KW - Phenols

U2 - 10.1007/s00394-019-02008-2

DO - 10.1007/s00394-019-02008-2

M3 - Journal article

C2 - 31139889

VL - 59

SP - 1517

EP - 1527

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

IS - 4

ER -

ID: 218709305