Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

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Standard

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism. / Williams, Kristine; Ingerslev, Lars Roed; Bork-Jensen, Jette; Wohlwend, Martin; Hansen, Ann Normann; Small, Lewin; Ribel-Madsen, Rasmus; Astrup, Arne; Pedersen, Oluf Borbye; Auwerx, Johan; Workman, Christopher T; Grarup, Niels; Hansen, Torben; Barrès, Romain.

I: Nature Communications, Bind 11, 2695, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Williams, K, Ingerslev, LR, Bork-Jensen, J, Wohlwend, M, Hansen, AN, Small, L, Ribel-Madsen, R, Astrup, A, Pedersen, OB, Auwerx, J, Workman, CT, Grarup, N, Hansen, T & Barrès, R 2020, 'Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism', Nature Communications, bind 11, 2695. https://doi.org/10.1038/s41467-020-16537-6

APA

Williams, K., Ingerslev, L. R., Bork-Jensen, J., Wohlwend, M., Hansen, A. N., Small, L., ... Barrès, R. (2020). Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism. Nature Communications, 11, [2695]. https://doi.org/10.1038/s41467-020-16537-6

Vancouver

Williams K, Ingerslev LR, Bork-Jensen J, Wohlwend M, Hansen AN, Small L o.a. Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism. Nature Communications. 2020;11. 2695. https://doi.org/10.1038/s41467-020-16537-6

Author

Williams, Kristine ; Ingerslev, Lars Roed ; Bork-Jensen, Jette ; Wohlwend, Martin ; Hansen, Ann Normann ; Small, Lewin ; Ribel-Madsen, Rasmus ; Astrup, Arne ; Pedersen, Oluf Borbye ; Auwerx, Johan ; Workman, Christopher T ; Grarup, Niels ; Hansen, Torben ; Barrès, Romain. / Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism. I: Nature Communications. 2020 ; Bind 11.

Bibtex

@article{51c65db04ffc495c919c849c4655ed66,
title = "Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism",
abstract = "Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors that are characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal. Numerous genetic variants have been associated with obesity and T2D, of which the majority are located in non-coding DNA regions. This suggests that most variants mediate their effect by altering the activity of gene-regulatory elements, including enhancers. Here, we map skeletal muscle genomic enhancer elements that are dynamically regulated after exposure to the free fatty acid palmitate or the inflammatory cytokine TNFα. By overlapping enhancer positions with the location of disease-associated genetic variants, and resolving long-range chromatin interactions between enhancers and gene promoters, we identify target genes involved in metabolic dysfunction in skeletal muscle. The majority of these genes also associate with altered whole-body metabolic phenotypes in the murine BXD genetic reference population. Thus, our combined genomic investigations identified genes that are involved in skeletal muscle metabolism.",
author = "Kristine Williams and Ingerslev, {Lars Roed} and Jette Bork-Jensen and Martin Wohlwend and Hansen, {Ann Normann} and Lewin Small and Rasmus Ribel-Madsen and Arne Astrup and Pedersen, {Oluf Borbye} and Johan Auwerx and Workman, {Christopher T} and Niels Grarup and Torben Hansen and Romain Barr{\`e}s",
note = "CURIS 2020 NEXS 179",
year = "2020",
doi = "10.1038/s41467-020-16537-6",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

AU - Williams, Kristine

AU - Ingerslev, Lars Roed

AU - Bork-Jensen, Jette

AU - Wohlwend, Martin

AU - Hansen, Ann Normann

AU - Small, Lewin

AU - Ribel-Madsen, Rasmus

AU - Astrup, Arne

AU - Pedersen, Oluf Borbye

AU - Auwerx, Johan

AU - Workman, Christopher T

AU - Grarup, Niels

AU - Hansen, Torben

AU - Barrès, Romain

N1 - CURIS 2020 NEXS 179

PY - 2020

Y1 - 2020

N2 - Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors that are characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal. Numerous genetic variants have been associated with obesity and T2D, of which the majority are located in non-coding DNA regions. This suggests that most variants mediate their effect by altering the activity of gene-regulatory elements, including enhancers. Here, we map skeletal muscle genomic enhancer elements that are dynamically regulated after exposure to the free fatty acid palmitate or the inflammatory cytokine TNFα. By overlapping enhancer positions with the location of disease-associated genetic variants, and resolving long-range chromatin interactions between enhancers and gene promoters, we identify target genes involved in metabolic dysfunction in skeletal muscle. The majority of these genes also associate with altered whole-body metabolic phenotypes in the murine BXD genetic reference population. Thus, our combined genomic investigations identified genes that are involved in skeletal muscle metabolism.

AB - Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors that are characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal. Numerous genetic variants have been associated with obesity and T2D, of which the majority are located in non-coding DNA regions. This suggests that most variants mediate their effect by altering the activity of gene-regulatory elements, including enhancers. Here, we map skeletal muscle genomic enhancer elements that are dynamically regulated after exposure to the free fatty acid palmitate or the inflammatory cytokine TNFα. By overlapping enhancer positions with the location of disease-associated genetic variants, and resolving long-range chromatin interactions between enhancers and gene promoters, we identify target genes involved in metabolic dysfunction in skeletal muscle. The majority of these genes also associate with altered whole-body metabolic phenotypes in the murine BXD genetic reference population. Thus, our combined genomic investigations identified genes that are involved in skeletal muscle metabolism.

U2 - 10.1038/s41467-020-16537-6

DO - 10.1038/s41467-020-16537-6

M3 - Journal article

C2 - 32483258

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2695

ER -

ID: 242605984