Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis

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Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber : results from a post-hoc analysis. / Hjorth, Mads Fiil; Blædel, Trine; Bendtsen, Line Quist; Lorenzen, Janne Kunchel; Holm, Jacob Bak; Kiilerich, Pia; Roager, Henrik Munch; Kristiansen, Karsten; Larsen, Lesli Hingstrup; Astrup, Arne.

I: International Journal of Obesity, Bind 43, Nr. 1, 2019, s. 149-157.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Hjorth, MF, Blædel, T, Bendtsen, LQ, Lorenzen, JK, Holm, JB, Kiilerich, P, Roager, HM, Kristiansen, K, Larsen, LH & Astrup, A 2019, 'Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis', International Journal of Obesity, bind 43, nr. 1, s. 149-157. https://doi.org/10.1038/s41366-018-0093-2

APA

Hjorth, M. F., Blædel, T., Bendtsen, L. Q., Lorenzen, J. K., Holm, J. B., Kiilerich, P., ... Astrup, A. (2019). Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis. International Journal of Obesity, 43(1), 149-157. https://doi.org/10.1038/s41366-018-0093-2

Vancouver

Hjorth MF, Blædel T, Bendtsen LQ, Lorenzen JK, Holm JB, Kiilerich P o.a. Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis. International Journal of Obesity. 2019;43(1):149-157. https://doi.org/10.1038/s41366-018-0093-2

Author

Hjorth, Mads Fiil ; Blædel, Trine ; Bendtsen, Line Quist ; Lorenzen, Janne Kunchel ; Holm, Jacob Bak ; Kiilerich, Pia ; Roager, Henrik Munch ; Kristiansen, Karsten ; Larsen, Lesli Hingstrup ; Astrup, Arne. / Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber : results from a post-hoc analysis. I: International Journal of Obesity. 2019 ; Bind 43, Nr. 1. s. 149-157.

Bibtex

@article{b251af79fa1c4cbcbe595c0472bbcc3b,
title = "Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis",
abstract = "Background/objectives: Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B.Subjects/methods: Eighty overweight participants were randomized (52 completed) to a 500 kcal/d energy deficit diet with a macronutrient composition of 30 energy percentage (E{\%}) fat, 52 E{\%} carbohydrate and 18 E{\%} protein either high (≈1500 mg calcium/day) or low ( ≤ 600 mg calcium/day) in dairy products for 24 weeks. Body weight, body fat, and dietary intake (by 7-day dietary records) were determined. Individuals were dichotomized according to their pre-treatment P/B ratio derived from 16S rRNA gene sequencing of collected fecal samples to test the potential modification of dietary effects using linear mixed models.Results: Independent of the randomized diets, individuals with high P/B lost 3.8 kg (95{\%}CI, 1.8,5.8; P < 0.001) more body weight and 3.8 kg (95{\%} CI, 1.1, 6.5; P = 0.005) more body fat compared to individuals with low P/B. After adjustment for multiple covariates, individuals with high P/B ratio lost 8.3 kg (95{\%} CI, 5.8;10.9, P < 0.001) more body weight when consuming above compared to below 30 g fiber/10MJ whereas this weight loss was 3.2 kg (95{\%} CI, 0.8;5.5, P = 0.008) among individuals with low P/B ratio [Mean difference: 5.1 kg (95{\%} CI, 1.7;8.6, P = 0.003)]. Partial correlation coefficients between fiber intake and weight change was 0.90 (P < 0.001) among individuals with high P/B ratio and 0.25 (P = 0.29) among individuals with low P/B ratio.Conclusions: Individuals with high P/B lost more body weight and body fat compared to individuals with low P/B, confirming that individuals with a high P/B are more susceptible to weight loss on a diet rich in fiber.",
keywords = "Faculty of Science, Obesity, Randomised controlled trials",
author = "Hjorth, {Mads Fiil} and Trine Bl{\ae}del and Bendtsen, {Line Quist} and Lorenzen, {Janne Kunchel} and Holm, {Jacob Bak} and Pia Kiilerich and Roager, {Henrik Munch} and Karsten Kristiansen and Larsen, {Lesli Hingstrup} and Arne Astrup",
note = "CURIS 2019 NEXS 023",
year = "2019",
doi = "10.1038/s41366-018-0093-2",
language = "English",
volume = "43",
pages = "149--157",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber

T2 - results from a post-hoc analysis

AU - Hjorth, Mads Fiil

AU - Blædel, Trine

AU - Bendtsen, Line Quist

AU - Lorenzen, Janne Kunchel

AU - Holm, Jacob Bak

AU - Kiilerich, Pia

AU - Roager, Henrik Munch

AU - Kristiansen, Karsten

AU - Larsen, Lesli Hingstrup

AU - Astrup, Arne

N1 - CURIS 2019 NEXS 023

PY - 2019

Y1 - 2019

N2 - Background/objectives: Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B.Subjects/methods: Eighty overweight participants were randomized (52 completed) to a 500 kcal/d energy deficit diet with a macronutrient composition of 30 energy percentage (E%) fat, 52 E% carbohydrate and 18 E% protein either high (≈1500 mg calcium/day) or low ( ≤ 600 mg calcium/day) in dairy products for 24 weeks. Body weight, body fat, and dietary intake (by 7-day dietary records) were determined. Individuals were dichotomized according to their pre-treatment P/B ratio derived from 16S rRNA gene sequencing of collected fecal samples to test the potential modification of dietary effects using linear mixed models.Results: Independent of the randomized diets, individuals with high P/B lost 3.8 kg (95%CI, 1.8,5.8; P < 0.001) more body weight and 3.8 kg (95% CI, 1.1, 6.5; P = 0.005) more body fat compared to individuals with low P/B. After adjustment for multiple covariates, individuals with high P/B ratio lost 8.3 kg (95% CI, 5.8;10.9, P < 0.001) more body weight when consuming above compared to below 30 g fiber/10MJ whereas this weight loss was 3.2 kg (95% CI, 0.8;5.5, P = 0.008) among individuals with low P/B ratio [Mean difference: 5.1 kg (95% CI, 1.7;8.6, P = 0.003)]. Partial correlation coefficients between fiber intake and weight change was 0.90 (P < 0.001) among individuals with high P/B ratio and 0.25 (P = 0.29) among individuals with low P/B ratio.Conclusions: Individuals with high P/B lost more body weight and body fat compared to individuals with low P/B, confirming that individuals with a high P/B are more susceptible to weight loss on a diet rich in fiber.

AB - Background/objectives: Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B.Subjects/methods: Eighty overweight participants were randomized (52 completed) to a 500 kcal/d energy deficit diet with a macronutrient composition of 30 energy percentage (E%) fat, 52 E% carbohydrate and 18 E% protein either high (≈1500 mg calcium/day) or low ( ≤ 600 mg calcium/day) in dairy products for 24 weeks. Body weight, body fat, and dietary intake (by 7-day dietary records) were determined. Individuals were dichotomized according to their pre-treatment P/B ratio derived from 16S rRNA gene sequencing of collected fecal samples to test the potential modification of dietary effects using linear mixed models.Results: Independent of the randomized diets, individuals with high P/B lost 3.8 kg (95%CI, 1.8,5.8; P < 0.001) more body weight and 3.8 kg (95% CI, 1.1, 6.5; P = 0.005) more body fat compared to individuals with low P/B. After adjustment for multiple covariates, individuals with high P/B ratio lost 8.3 kg (95% CI, 5.8;10.9, P < 0.001) more body weight when consuming above compared to below 30 g fiber/10MJ whereas this weight loss was 3.2 kg (95% CI, 0.8;5.5, P = 0.008) among individuals with low P/B ratio [Mean difference: 5.1 kg (95% CI, 1.7;8.6, P = 0.003)]. Partial correlation coefficients between fiber intake and weight change was 0.90 (P < 0.001) among individuals with high P/B ratio and 0.25 (P = 0.29) among individuals with low P/B ratio.Conclusions: Individuals with high P/B lost more body weight and body fat compared to individuals with low P/B, confirming that individuals with a high P/B are more susceptible to weight loss on a diet rich in fiber.

KW - Faculty of Science

KW - Obesity

KW - Randomised controlled trials

U2 - 10.1038/s41366-018-0093-2

DO - 10.1038/s41366-018-0093-2

M3 - Journal article

C2 - 29777234

VL - 43

SP - 149

EP - 157

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 1

ER -

ID: 196711739