PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results

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Elke Dorenbos, Mathijs Drummen, Jesse Rijks, Tanja Adam, Pauline Stouthart, J Alfredo Martínez, Santiago Navas-Carretero, Gareth Stratton, Nils Swindell, Mikael Fogelholm, Anne Raben, Margriet Westerterp-Plantenga, Anita Vreugdenhil

Insulin resistance (IR) in adolescence is associated with T2DM. The PREVIEW study assesses the effectiveness of a high-protein, low-glycaemic index diet and moderate-protein, moderate-glycaemic index diet to decrease IR in insulin resistant children with overweight/obesity. Inclusion criteria were age 10-17y, HOMA-IR≥2.0 and overweight/obesity. In 126 children (13.6±2.2y, BMI z-score 3.04±0.66, HOMA-IR 3.48±2.28) anthropometrics, fat mass percentage (FM%), metabolic parameters, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41±1.86 vs. 3.23±1.86, p=0.007) and prepubertal and pubertal children with overweight/obesity (vs. 3.61±1.60, p=0.004 and vs. 3.40±1.50, p<0.001 respectively). IR was associated with sex, Tanner stage, BMI z-score, and FM%. Fasting glucose concentrations were negatively associated with Baecke Sport (r=-0.223, p=0.025) and positively with daytime sleepiness (r=0.280, p=0.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The relations between fasting glucose concentration with Baecke Sport and sleepiness suggest these might be possible targets for diabetes prevention.

OriginalsprogEngelsk
TidsskriftDiabetes, Obesity and Metabolism
Vol/bind20
Udgave nummer5
Sider (fra-til)1096-1101
Antal sider6
ISSN1462-8902
DOI
StatusUdgivet - 2018

Bibliografisk note

CURIS 2018 NEXS 062

ID: 188447449