Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Ping Wang
  • Paul P C A Menheere
  • Astrup, Arne
  • Malene R Andersen
  • Marleen A van Baak
  • Thomas Meinert Larsen
  • Susan Jebb
  • Anthony Kafatos
  • Andreas F H Pfeiffer
  • J Alfredo Martinez
  • Teodora Handjieva-Darlenska
  • Petr Hlavaty
  • Nathalie Viguerie
  • Dominique Langin
  • Wim H M Saris
  • Edwin C M Mariman
  • on behalf of Diogenes consortium
OBJECTIVE: Weight loss helps reduce the symptoms of the metabolic syndrome (MetS) in the obese, but weight regain after active weight loss is common. We investigated the changes and predictive role of circulating adipokines and sex hormones for weight regain in men during dietary intervention, and also the effect of basal MetS status on weight regain. DESIGN AND METHODS: Twenty-four men who continued to lose weight (WL) and 24 men who regained weight (WR) during the 6-month follow-up period after weight loss were selected from the Diogenes Study. Their circulating concentrations of leptin, adiponectin, retinol-binding protein 4 (RBP4), luteinizing hormone, prolactin, progesterone, total and free testosterone, and sex hormone-binding globulin (SHBG) were measured at baseline, after 8-week low-calorie diet-induced active weight loss, and after a subsequent 26-week ad libitum weight maintenance diet, and analyzed together with anthropometrical and physiological parameters. RESULTS AND CONCLUSIONS: Overweight and obese men with MetS at baseline had higher risk to regain weight (odds ratio=2.8, P=0.015). High baseline RBP4, and low total testosterone and low SHBG are predictors of weight loss regain (different between WR and WL with P=0.001, 0.038, 0.044, respectively), and may play roles in the link between MetS and weight loss regain.
OriginalsprogEngelsk
TidsskriftObesity
Vol/bind21
Udgave nummer10
Sider (fra-til)1997-2006
Antal sider10
ISSN1930-7381
DOI
StatusUdgivet - 2013

Bibliografisk note

CURIS 2013 NEXS 076

ID: 44853711