Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids : the DiOGenes study. / Brahe, Lena Kirchner; Angquist, Lars; Larsen, Lesli Hingstrup; Vimaleswaran, Karani S; Hager, Jörg; Viguerie, Nathalie; Loos, Ruth J F; Handjieva-Darlenska, Teodora; Jebb, Susan A; Hlavaty, Petr; Larsen, Thomas Meinert; Martinez, J Alfredo; Papadaki, Angeliki; Pfeiffer, Andreas F H; van Baak, Marleen A; Sørensen, Thorkild I A; Holst, Claus; Langin, Dominique; Astrup, Arne; Saris, Wim H M.

I: British Journal of Nutrition, Bind 110, Nr. 5, 2013, s. 790-796.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Brahe, LK, Angquist, L, Larsen, LH, Vimaleswaran, KS, Hager, J, Viguerie, N, Loos, RJF, Handjieva-Darlenska, T, Jebb, SA, Hlavaty, P, Larsen, TM, Martinez, JA, Papadaki, A, Pfeiffer, AFH, van Baak, MA, Sørensen, TIA, Holst, C, Langin, D, Astrup, A & Saris, WHM 2013, 'Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study', British Journal of Nutrition, bind 110, nr. 5, s. 790-796. https://doi.org/10.1017/S0007114512006058

APA

Brahe, L. K., Angquist, L., Larsen, L. H., Vimaleswaran, K. S., Hager, J., Viguerie, N., ... Saris, W. H. M. (2013). Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study. British Journal of Nutrition, 110(5), 790-796. https://doi.org/10.1017/S0007114512006058

Vancouver

Brahe LK, Angquist L, Larsen LH, Vimaleswaran KS, Hager J, Viguerie N o.a. Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study. British Journal of Nutrition. 2013;110(5):790-796. https://doi.org/10.1017/S0007114512006058

Author

Brahe, Lena Kirchner ; Angquist, Lars ; Larsen, Lesli Hingstrup ; Vimaleswaran, Karani S ; Hager, Jörg ; Viguerie, Nathalie ; Loos, Ruth J F ; Handjieva-Darlenska, Teodora ; Jebb, Susan A ; Hlavaty, Petr ; Larsen, Thomas Meinert ; Martinez, J Alfredo ; Papadaki, Angeliki ; Pfeiffer, Andreas F H ; van Baak, Marleen A ; Sørensen, Thorkild I A ; Holst, Claus ; Langin, Dominique ; Astrup, Arne ; Saris, Wim H M. / Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids : the DiOGenes study. I: British Journal of Nutrition. 2013 ; Bind 110, Nr. 5. s. 790-796.

Bibtex

@article{503d2240885547edb4bac158640f048b,
title = "Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study",
abstract = "Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 {\%} CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.",
author = "Brahe, {Lena Kirchner} and Lars Angquist and Larsen, {Lesli Hingstrup} and Vimaleswaran, {Karani S} and J{\"o}rg Hager and Nathalie Viguerie and Loos, {Ruth J F} and Teodora Handjieva-Darlenska and Jebb, {Susan A} and Petr Hlavaty and Larsen, {Thomas Meinert} and Martinez, {J Alfredo} and Angeliki Papadaki and Pfeiffer, {Andreas F H} and {van Baak}, {Marleen A} and S{\o}rensen, {Thorkild I A} and Claus Holst and Dominique Langin and Arne Astrup and Saris, {Wim H M}",
note = "CURIS 2013 NEXS 083",
year = "2013",
doi = "10.1017/S0007114512006058",
language = "English",
volume = "110",
pages = "790--796",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids

T2 - the DiOGenes study

AU - Brahe, Lena Kirchner

AU - Angquist, Lars

AU - Larsen, Lesli Hingstrup

AU - Vimaleswaran, Karani S

AU - Hager, Jörg

AU - Viguerie, Nathalie

AU - Loos, Ruth J F

AU - Handjieva-Darlenska, Teodora

AU - Jebb, Susan A

AU - Hlavaty, Petr

AU - Larsen, Thomas Meinert

AU - Martinez, J Alfredo

AU - Papadaki, Angeliki

AU - Pfeiffer, Andreas F H

AU - van Baak, Marleen A

AU - Sørensen, Thorkild I A

AU - Holst, Claus

AU - Langin, Dominique

AU - Astrup, Arne

AU - Saris, Wim H M

N1 - CURIS 2013 NEXS 083

PY - 2013

Y1 - 2013

N2 - Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 % CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.

AB - Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 % CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.

U2 - 10.1017/S0007114512006058

DO - 10.1017/S0007114512006058

M3 - Journal article

C2 - 23360819

VL - 110

SP - 790

EP - 796

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 5

ER -

ID: 44865894