Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

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Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children. / Schnurr, Theresia Maria; Viitasalo, A; Eloranta, A-M; Damsgaard, Camilla Trab; Mahendran, Yuvaraj; Have, Christian Theil; Väistö, J; Hjorth, Mads Fiil; Christensen, Line Brinch; Brage, S; Atalay, M; Lyytikäinen, L-P; Lindi, V; Lakka, T; Michaelsen, Kim F.; Kilpeläinen, Tuomas Oskari; Hansen, Torben.

I: International Journal of Obesity, Bind 42, Nr. 1, 2018, s. 111-114.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Schnurr, TM, Viitasalo, A, Eloranta, A-M, Damsgaard, CT, Mahendran, Y, Have, CT, Väistö, J, Hjorth, MF, Christensen, LB, Brage, S, Atalay, M, Lyytikäinen, L-P, Lindi, V, Lakka, T, Michaelsen, KF, Kilpeläinen, TO & Hansen, T 2018, 'Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children', International Journal of Obesity, bind 42, nr. 1, s. 111-114. https://doi.org/10.1038/ijo.2017.235

APA

Schnurr, T. M., Viitasalo, A., Eloranta, A-M., Damsgaard, C. T., Mahendran, Y., Have, C. T., ... Hansen, T. (2018). Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children. International Journal of Obesity, 42(1), 111-114. https://doi.org/10.1038/ijo.2017.235

Vancouver

Schnurr TM, Viitasalo A, Eloranta A-M, Damsgaard CT, Mahendran Y, Have CT o.a. Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children. International Journal of Obesity. 2018;42(1):111-114. https://doi.org/10.1038/ijo.2017.235

Author

Schnurr, Theresia Maria ; Viitasalo, A ; Eloranta, A-M ; Damsgaard, Camilla Trab ; Mahendran, Yuvaraj ; Have, Christian Theil ; Väistö, J ; Hjorth, Mads Fiil ; Christensen, Line Brinch ; Brage, S ; Atalay, M ; Lyytikäinen, L-P ; Lindi, V ; Lakka, T ; Michaelsen, Kim F. ; Kilpeläinen, Tuomas Oskari ; Hansen, Torben. / Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children. I: International Journal of Obesity. 2018 ; Bind 42, Nr. 1. s. 111-114.

Bibtex

@article{2eece96bf1054f5d9ce6a629599446d7,
title = "Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children",
abstract = "Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [NTOTAL=679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.International Journal of Obesity accepted article preview online, 26 September 2017. doi:10.1038/ijo.2017.235.",
keywords = "Genetic risk score, Childhood BMI, Adiposity, Sedentary time, Mendelian randomization",
author = "Schnurr, {Theresia Maria} and A Viitasalo and A-M Eloranta and Damsgaard, {Camilla Trab} and Yuvaraj Mahendran and Have, {Christian Theil} and J V{\"a}ist{\"o} and Hjorth, {Mads Fiil} and Christensen, {Line Brinch} and S Brage and M Atalay and L-P Lyytik{\"a}inen and V Lindi and T Lakka and Michaelsen, {Kim F.} and Kilpel{\"a}inen, {Tuomas Oskari} and Torben Hansen",
note = "CURIS 2018 NEXS 035",
year = "2018",
doi = "10.1038/ijo.2017.235",
language = "English",
volume = "42",
pages = "111--114",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

AU - Schnurr, Theresia Maria

AU - Viitasalo, A

AU - Eloranta, A-M

AU - Damsgaard, Camilla Trab

AU - Mahendran, Yuvaraj

AU - Have, Christian Theil

AU - Väistö, J

AU - Hjorth, Mads Fiil

AU - Christensen, Line Brinch

AU - Brage, S

AU - Atalay, M

AU - Lyytikäinen, L-P

AU - Lindi, V

AU - Lakka, T

AU - Michaelsen, Kim F.

AU - Kilpeläinen, Tuomas Oskari

AU - Hansen, Torben

N1 - CURIS 2018 NEXS 035

PY - 2018

Y1 - 2018

N2 - Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [NTOTAL=679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.International Journal of Obesity accepted article preview online, 26 September 2017. doi:10.1038/ijo.2017.235.

AB - Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [NTOTAL=679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.International Journal of Obesity accepted article preview online, 26 September 2017. doi:10.1038/ijo.2017.235.

KW - Genetic risk score

KW - Childhood BMI

KW - Adiposity

KW - Sedentary time

KW - Mendelian randomization

U2 - 10.1038/ijo.2017.235

DO - 10.1038/ijo.2017.235

M3 - Journal article

C2 - 28947836

VL - 42

SP - 111

EP - 114

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 1

ER -

ID: 184065158