Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Peter Jensen, Claus Zachariae, Robin Christensen, Nina R W Geiker, Bente K Schaadt, Steen Stender, Arne Astrup, Peter Riis Hansen, Lone Skov

Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction.
OriginalsprogEngelsk
TidsskriftActa Dermatovenereologica
Vol/bind94
Udgave nummer6
Sider (fra-til)691-694
Antal sider4
ISSN0001-5555
DOI
StatusUdgivet - 2014

Bibliografisk note

CURIS 2014 NEXS 102

ID: 105860577