Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in non-obese Asians

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Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in non-obese Asians. / Chan, Zhiling; Ding, Cherlyn; Chooi, Yu Chung; Choo, John; Sadananthan, Suresh Anand; Sasikala, S; Chang, Amanda; Michael, Navin; Velan, S Sendhil; Leow, Melvin K-S; Magkos, Faidon.

I: European Journal of Clinical Investigation, Bind 49, Nr. 5, e13079, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Chan, Z, Ding, C, Chooi, YC, Choo, J, Sadananthan, SA, Sasikala, S, Chang, A, Michael, N, Velan, SS, Leow, MK-S & Magkos, F 2019, 'Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in non-obese Asians', European Journal of Clinical Investigation, bind 49, nr. 5, e13079. https://doi.org/10.1111/eci.13079

APA

Chan, Z., Ding, C., Chooi, Y. C., Choo, J., Sadananthan, S. A., Sasikala, S., ... Magkos, F. (2019). Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in non-obese Asians. European Journal of Clinical Investigation, 49(5), [e13079]. https://doi.org/10.1111/eci.13079

Vancouver

Chan Z, Ding C, Chooi YC, Choo J, Sadananthan SA, Sasikala S o.a. Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in non-obese Asians. European Journal of Clinical Investigation. 2019;49(5). e13079. https://doi.org/10.1111/eci.13079

Author

Chan, Zhiling ; Ding, Cherlyn ; Chooi, Yu Chung ; Choo, John ; Sadananthan, Suresh Anand ; Sasikala, S ; Chang, Amanda ; Michael, Navin ; Velan, S Sendhil ; Leow, Melvin K-S ; Magkos, Faidon. / Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in non-obese Asians. I: European Journal of Clinical Investigation. 2019 ; Bind 49, Nr. 5.

Bibtex

@article{5395a4c32ee741189f259995e492f66c,
title = "Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in non-obese Asians",
abstract = "Background: The importance of ectopic fat deposition and physical fitness in the pathogenesis of insulin resistance and beta cell dysfunction in non-obese Asians is not known.Materials and methods: We conducted a cross-sectional study and measured insulin sensitivity (M value; 4-h hyperinsulinaemic-euglycaemic clamp), insulin secretion rate (3-h mixed meal tolerance test with oral minimal modelling), percent body fat, visceral adipose tissue, intramyocellular and intrahepatic lipid contents (magnetic resonance imaging and spectroscopy), cardiorespiratory fitness (VO2max; graded exercise test) and habitual physical activity (short International Physical Activity Questionnaire) in 60 healthy non-obese Asian subjects (BMI=21.9±1.7 kg/m2 , age=41.8±13.4 years).Results: M was inversely associated with percent body fat (r=-0.460, p<0.001), visceral fat (r=-0.623, p<0.001) and liver fat (r=-0.601, p<0.001), whereas insulin secretion correlated positively with these adiposity indices (percent body fat: r=0.303, p=0.018; visceral fat: r=0.409, p=0.010; hepatic fat: r=0.393, p=0.002). VO2max correlated negatively with insulin secretion rate (r=-0.420, p<0.001) and positively with M (r=0.658, p<0.001). The amount of vigorous physical activity was positively associated with VO2max (r=0.682, p<0.001). Multiple stepwise linear regression analyses indicated that VO2max, age, and IHTG or VAT were independent determinants of insulin sensitivity and secretion (adjusted R2 =69{\%} and 33{\%}, respectively, p<0.001).Conclusions: Increased ectopic fat deposition is associated with reduced insulin sensitivity and increased insulin secretion in healthy non-obese Asians. Poor cardiorespiratory fitness, likely due to inadequate participation in vigorous exercise, is strongly related to suboptimal metabolic function. Interventions to encourage engagement in physical activity may thus be important for improving metabolic health in non-obese Asians. This article is protected by copyright. All rights reserved.Trial registration: ClinicalTrials.gov NCT03239782",
keywords = "Faculty of Science, Metabolic function, Diabetes, Fitness, Physical activity",
author = "Zhiling Chan and Cherlyn Ding and Chooi, {Yu Chung} and John Choo and Sadananthan, {Suresh Anand} and S Sasikala and Amanda Chang and Navin Michael and Velan, {S Sendhil} and Leow, {Melvin K-S} and Faidon Magkos",
note = "CURIS 2019 NEXS 076",
year = "2019",
doi = "10.1111/eci.13079",
language = "English",
volume = "49",
journal = "European Journal of Clinical Investigation. Supplement",
issn = "0960-135X",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in non-obese Asians

AU - Chan, Zhiling

AU - Ding, Cherlyn

AU - Chooi, Yu Chung

AU - Choo, John

AU - Sadananthan, Suresh Anand

AU - Sasikala, S

AU - Chang, Amanda

AU - Michael, Navin

AU - Velan, S Sendhil

AU - Leow, Melvin K-S

AU - Magkos, Faidon

N1 - CURIS 2019 NEXS 076

PY - 2019

Y1 - 2019

N2 - Background: The importance of ectopic fat deposition and physical fitness in the pathogenesis of insulin resistance and beta cell dysfunction in non-obese Asians is not known.Materials and methods: We conducted a cross-sectional study and measured insulin sensitivity (M value; 4-h hyperinsulinaemic-euglycaemic clamp), insulin secretion rate (3-h mixed meal tolerance test with oral minimal modelling), percent body fat, visceral adipose tissue, intramyocellular and intrahepatic lipid contents (magnetic resonance imaging and spectroscopy), cardiorespiratory fitness (VO2max; graded exercise test) and habitual physical activity (short International Physical Activity Questionnaire) in 60 healthy non-obese Asian subjects (BMI=21.9±1.7 kg/m2 , age=41.8±13.4 years).Results: M was inversely associated with percent body fat (r=-0.460, p<0.001), visceral fat (r=-0.623, p<0.001) and liver fat (r=-0.601, p<0.001), whereas insulin secretion correlated positively with these adiposity indices (percent body fat: r=0.303, p=0.018; visceral fat: r=0.409, p=0.010; hepatic fat: r=0.393, p=0.002). VO2max correlated negatively with insulin secretion rate (r=-0.420, p<0.001) and positively with M (r=0.658, p<0.001). The amount of vigorous physical activity was positively associated with VO2max (r=0.682, p<0.001). Multiple stepwise linear regression analyses indicated that VO2max, age, and IHTG or VAT were independent determinants of insulin sensitivity and secretion (adjusted R2 =69% and 33%, respectively, p<0.001).Conclusions: Increased ectopic fat deposition is associated with reduced insulin sensitivity and increased insulin secretion in healthy non-obese Asians. Poor cardiorespiratory fitness, likely due to inadequate participation in vigorous exercise, is strongly related to suboptimal metabolic function. Interventions to encourage engagement in physical activity may thus be important for improving metabolic health in non-obese Asians. This article is protected by copyright. All rights reserved.Trial registration: ClinicalTrials.gov NCT03239782

AB - Background: The importance of ectopic fat deposition and physical fitness in the pathogenesis of insulin resistance and beta cell dysfunction in non-obese Asians is not known.Materials and methods: We conducted a cross-sectional study and measured insulin sensitivity (M value; 4-h hyperinsulinaemic-euglycaemic clamp), insulin secretion rate (3-h mixed meal tolerance test with oral minimal modelling), percent body fat, visceral adipose tissue, intramyocellular and intrahepatic lipid contents (magnetic resonance imaging and spectroscopy), cardiorespiratory fitness (VO2max; graded exercise test) and habitual physical activity (short International Physical Activity Questionnaire) in 60 healthy non-obese Asian subjects (BMI=21.9±1.7 kg/m2 , age=41.8±13.4 years).Results: M was inversely associated with percent body fat (r=-0.460, p<0.001), visceral fat (r=-0.623, p<0.001) and liver fat (r=-0.601, p<0.001), whereas insulin secretion correlated positively with these adiposity indices (percent body fat: r=0.303, p=0.018; visceral fat: r=0.409, p=0.010; hepatic fat: r=0.393, p=0.002). VO2max correlated negatively with insulin secretion rate (r=-0.420, p<0.001) and positively with M (r=0.658, p<0.001). The amount of vigorous physical activity was positively associated with VO2max (r=0.682, p<0.001). Multiple stepwise linear regression analyses indicated that VO2max, age, and IHTG or VAT were independent determinants of insulin sensitivity and secretion (adjusted R2 =69% and 33%, respectively, p<0.001).Conclusions: Increased ectopic fat deposition is associated with reduced insulin sensitivity and increased insulin secretion in healthy non-obese Asians. Poor cardiorespiratory fitness, likely due to inadequate participation in vigorous exercise, is strongly related to suboptimal metabolic function. Interventions to encourage engagement in physical activity may thus be important for improving metabolic health in non-obese Asians. This article is protected by copyright. All rights reserved.Trial registration: ClinicalTrials.gov NCT03239782

KW - Faculty of Science

KW - Metabolic function

KW - Diabetes

KW - Fitness

KW - Physical activity

U2 - 10.1111/eci.13079

DO - 10.1111/eci.13079

M3 - Journal article

C2 - 30734926

VL - 49

JO - European Journal of Clinical Investigation. Supplement

JF - European Journal of Clinical Investigation. Supplement

SN - 0960-135X

IS - 5

M1 - e13079

ER -

ID: 213152207