Cortical signatures of precision grip force control in children, adolescents and adults

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Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous control we analyzed electroencephalographic data from 88 individuals (range 8-30y) performing a visually-guided precision grip task using Dynamic Causal Modelling (DCM) and Parametric Empirical Bayes (PEB). Our results demonstrate that bidirectional coupling in a canonical 'grasping network' is associated with precision grip performance across age groups. We further demonstrate greater backward coupling from higher-order to lower-order sensorimotor regions from late adolescence in addition to differential associations between connectivity strength in a premotor-prefrontal network and motor performance for different age groups. We interpret these findings as reflecting greater use of top-down and executive control processes with development. These results expand our understanding of the cortical mechanisms that support dexterous abilities through development.

Antal sider22
StatusUdgivet - 2021

Bibliografisk note

CURIS 2021 NEXS 215

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