Caloric restriction and diet-induced weight loss do not induce browning of human subcutaneous white adipose tissue in women and men with obesity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Caloric restriction and diet-induced weight loss do not induce browning of human subcutaneous white adipose tissue in women and men with obesity. / Barquissau, Valentin; Léger, Benjamin; Beuzelin, Diane; Martins, Frédéric; Amri, Ez-Zoubir; Pisani, Didier F; Saris, Wim H M ; Astrup, Arne; Maoret, Jean-José; Iacovoni, Jason S; Déjean, Sebastien; Moro, Cedric; Viguerie, Nathalie; Langin, Dominique.

I: Cell Reports, Bind 22, 2018, s. 1079-1089.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Barquissau, V, Léger, B, Beuzelin, D, Martins, F, Amri, E-Z, Pisani, DF, Saris, WHM, Astrup, A, Maoret, J-J, Iacovoni, JS, Déjean, S, Moro, C, Viguerie, N & Langin, D 2018, 'Caloric restriction and diet-induced weight loss do not induce browning of human subcutaneous white adipose tissue in women and men with obesity', Cell Reports, bind 22, s. 1079-1089. https://doi.org/10.1016/j.celrep.2017.12.102

APA

Barquissau, V., Léger, B., Beuzelin, D., Martins, F., Amri, E-Z., Pisani, D. F., ... Langin, D. (2018). Caloric restriction and diet-induced weight loss do not induce browning of human subcutaneous white adipose tissue in women and men with obesity. Cell Reports, 22, 1079-1089. https://doi.org/10.1016/j.celrep.2017.12.102

Vancouver

Barquissau V, Léger B, Beuzelin D, Martins F, Amri E-Z, Pisani DF o.a. Caloric restriction and diet-induced weight loss do not induce browning of human subcutaneous white adipose tissue in women and men with obesity. Cell Reports. 2018;22:1079-1089. https://doi.org/10.1016/j.celrep.2017.12.102

Author

Barquissau, Valentin ; Léger, Benjamin ; Beuzelin, Diane ; Martins, Frédéric ; Amri, Ez-Zoubir ; Pisani, Didier F ; Saris, Wim H M ; Astrup, Arne ; Maoret, Jean-José ; Iacovoni, Jason S ; Déjean, Sebastien ; Moro, Cedric ; Viguerie, Nathalie ; Langin, Dominique. / Caloric restriction and diet-induced weight loss do not induce browning of human subcutaneous white adipose tissue in women and men with obesity. I: Cell Reports. 2018 ; Bind 22. s. 1079-1089.

Bibtex

@article{f8f33b163b1a434da090ee7e439166fc,
title = "Caloric restriction and diet-induced weight loss do not induce browning of human subcutaneous white adipose tissue in women and men with obesity",
abstract = "Caloric restriction (CR) is standard lifestyle therapy in obesity management. CR-induced weight loss improves the metabolic profile of individuals with obesity. In mice, occurrence of beige fat cells in white fat depots favors a metabolically healthy phenotype, and CR promotes browning of white adipose tissue (WAT). Here, human subcutaneous abdominal WAT samples were analyzed in 289 individuals with obesity following a two-phase dietary intervention consisting of an 8 week very low calorie diet and a 6-month weight-maintenance phase. Before the intervention, we show sex differences and seasonal variation, with higher expression of brown and beige markers in women with obesity and during winter, respectively. The very low calorie diet resulted in decreased browning of subcutaneous abdominal WAT. During the whole dietary intervention, evolution of body fat and insulin resistance was independent ofchanges in brown and beige fat markers. These data suggest that diet-induced effects on body fat and insulin resistance are independent of subcutaneousabdominal WAT browning in people with obesity.",
author = "Valentin Barquissau and Benjamin L{\'e}ger and Diane Beuzelin and Fr{\'e}d{\'e}ric Martins and Ez-Zoubir Amri and Pisani, {Didier F} and Saris, {Wim H M} and Arne Astrup and Jean-Jos{\'e} Maoret and Iacovoni, {Jason S} and Sebastien D{\'e}jean and Cedric Moro and Nathalie Viguerie and Dominique Langin",
note = "CURIS 2018 NEXS 040",
year = "2018",
doi = "10.1016/j.celrep.2017.12.102",
language = "English",
volume = "22",
pages = "1079--1089",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",

}

RIS

TY - JOUR

T1 - Caloric restriction and diet-induced weight loss do not induce browning of human subcutaneous white adipose tissue in women and men with obesity

AU - Barquissau, Valentin

AU - Léger, Benjamin

AU - Beuzelin, Diane

AU - Martins, Frédéric

AU - Amri, Ez-Zoubir

AU - Pisani, Didier F

AU - Saris, Wim H M

AU - Astrup, Arne

AU - Maoret, Jean-José

AU - Iacovoni, Jason S

AU - Déjean, Sebastien

AU - Moro, Cedric

AU - Viguerie, Nathalie

AU - Langin, Dominique

N1 - CURIS 2018 NEXS 040

PY - 2018

Y1 - 2018

N2 - Caloric restriction (CR) is standard lifestyle therapy in obesity management. CR-induced weight loss improves the metabolic profile of individuals with obesity. In mice, occurrence of beige fat cells in white fat depots favors a metabolically healthy phenotype, and CR promotes browning of white adipose tissue (WAT). Here, human subcutaneous abdominal WAT samples were analyzed in 289 individuals with obesity following a two-phase dietary intervention consisting of an 8 week very low calorie diet and a 6-month weight-maintenance phase. Before the intervention, we show sex differences and seasonal variation, with higher expression of brown and beige markers in women with obesity and during winter, respectively. The very low calorie diet resulted in decreased browning of subcutaneous abdominal WAT. During the whole dietary intervention, evolution of body fat and insulin resistance was independent ofchanges in brown and beige fat markers. These data suggest that diet-induced effects on body fat and insulin resistance are independent of subcutaneousabdominal WAT browning in people with obesity.

AB - Caloric restriction (CR) is standard lifestyle therapy in obesity management. CR-induced weight loss improves the metabolic profile of individuals with obesity. In mice, occurrence of beige fat cells in white fat depots favors a metabolically healthy phenotype, and CR promotes browning of white adipose tissue (WAT). Here, human subcutaneous abdominal WAT samples were analyzed in 289 individuals with obesity following a two-phase dietary intervention consisting of an 8 week very low calorie diet and a 6-month weight-maintenance phase. Before the intervention, we show sex differences and seasonal variation, with higher expression of brown and beige markers in women with obesity and during winter, respectively. The very low calorie diet resulted in decreased browning of subcutaneous abdominal WAT. During the whole dietary intervention, evolution of body fat and insulin resistance was independent ofchanges in brown and beige fat markers. These data suggest that diet-induced effects on body fat and insulin resistance are independent of subcutaneousabdominal WAT browning in people with obesity.

U2 - 10.1016/j.celrep.2017.12.102

DO - 10.1016/j.celrep.2017.12.102

M3 - Journal article

C2 - 29386128

VL - 22

SP - 1079

EP - 1089

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

ER -

ID: 188753032