Winter cholecalciferol supplementation at 55°N has no effect on markers of cardiometabolic risk in healthy children aged 4-8 years

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Standard

Winter cholecalciferol supplementation at 55°N has no effect on markers of cardiometabolic risk in healthy children aged 4-8 years. / Hauger, Hanne; Mølgaard, Christian; Mortensen, Charlotte; Ritz, Christian; Frøkiær, Hanne; Smith, Taryn J; Hart, Kathryn; Lanham-New, Susan A; Damsgaard, Camilla Trab.

I: Journal of Nutrition, Bind 148, Nr. 8, 2018, s. 1261-1268.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Hauger, H, Mølgaard, C, Mortensen, C, Ritz, C, Frøkiær, H, Smith, TJ, Hart, K, Lanham-New, SA & Damsgaard, CT 2018, 'Winter cholecalciferol supplementation at 55°N has no effect on markers of cardiometabolic risk in healthy children aged 4-8 years', Journal of Nutrition, bind 148, nr. 8, s. 1261-1268. https://doi.org/10.1093/jn/nxy080

APA

Hauger, H., Mølgaard, C., Mortensen, C., Ritz, C., Frøkiær, H., Smith, T. J., ... Damsgaard, C. T. (2018). Winter cholecalciferol supplementation at 55°N has no effect on markers of cardiometabolic risk in healthy children aged 4-8 years. Journal of Nutrition, 148(8), 1261-1268. https://doi.org/10.1093/jn/nxy080

Vancouver

Hauger H, Mølgaard C, Mortensen C, Ritz C, Frøkiær H, Smith TJ o.a. Winter cholecalciferol supplementation at 55°N has no effect on markers of cardiometabolic risk in healthy children aged 4-8 years. Journal of Nutrition. 2018;148(8):1261-1268. https://doi.org/10.1093/jn/nxy080

Author

Hauger, Hanne ; Mølgaard, Christian ; Mortensen, Charlotte ; Ritz, Christian ; Frøkiær, Hanne ; Smith, Taryn J ; Hart, Kathryn ; Lanham-New, Susan A ; Damsgaard, Camilla Trab. / Winter cholecalciferol supplementation at 55°N has no effect on markers of cardiometabolic risk in healthy children aged 4-8 years. I: Journal of Nutrition. 2018 ; Bind 148, Nr. 8. s. 1261-1268.

Bibtex

@article{a841e581bd3e495885f11e03a39b9903,
title = "Winter cholecalciferol supplementation at 55°N has no effect on markers of cardiometabolic risk in healthy children aged 4-8 years",
abstract = "Background: Low serum 25-hydroxyvitamin D [25(OH)D] has been associated with unfavorable cardiometabolic risk profiles in many observational studies in children, but very few randomized controlled trials have investigated this.Objective: We explored the effect of winter-time cholecalciferol (vitamin D3) supplementation on cardiometabolic risk markers in young, white, 4- to 8-y-old healthy Danish children (55°N) as part of the pan-European ODIN project.Methods: In the ODIN Junior double-blind, placebo-controlled, dose-response trial, 119 children (mean ± SD age: 6.7 ± 1.5 y; 36{\%} male; 82{\%} normal weight) were randomly allocated to 0, 10 or 20 µg/d of vitamin D3 for 20 wk (October-March). Cardiometabolic risk markers including BMI-for-age z score (BMIz), waist circumference, systolic and diastolic blood pressure, serum triglycerides and cholesterol (total, LDL, HDL, and total:HDL), plasma glucose and insulin, and whole-blood glycated hemoglobin were measured at baseline and endpoint as secondary outcomes together with serum 25(OH)D. Intervention effects were evaluated in linear regression models as between-group differences at endpoint adjusted for baseline value of the outcome, and additionally for age, sex, baseline serum 25(OH)D, BMIz, time since breakfast, and breakfast content.Results: Mean ± SD serum 25(OH)D was 56.7 ± 12.3 nmol/L at baseline and differed between groups at endpoint with concentrations of 31.1 ± 7.5, 61.8 ± 10.6, and 75.8 ± 11.5 nmol/L in the 0-, 10-, and 20 µg/d groups, respectively (P < 0.0001). Vitamin D3 supplementation had no effect on any of the cardiometabolic risk markers in analyses adjusted for baseline value of the outcome (all P ≥ 0.05), and additional covariate adjustment did not change the results notably.Conclusions: Preventing the winter decline in serum 25(OH)D with daily vitamin D3 supplementation of 10 or 20 µg had no cardiometabolic effects in healthy 4- to 8-y-old Danish children. This trial was registered at www.clinicaltrials.gov as NCT02145195.",
keywords = "The Faculty of Science, Randomized controlled trial, Vitamin D, Cardiovascular risk factors, Children, ODIN",
author = "Hanne Hauger and Christian M{\o}lgaard and Charlotte Mortensen and Christian Ritz and Hanne Fr{\o}ki{\ae}r and Smith, {Taryn J} and Kathryn Hart and Lanham-New, {Susan A} and Damsgaard, {Camilla Trab}",
note = "CURIS 2018 NEXS 205",
year = "2018",
doi = "10.1093/jn/nxy080",
language = "English",
volume = "148",
pages = "1261--1268",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "8",

}

RIS

TY - JOUR

T1 - Winter cholecalciferol supplementation at 55°N has no effect on markers of cardiometabolic risk in healthy children aged 4-8 years

AU - Hauger, Hanne

AU - Mølgaard, Christian

AU - Mortensen, Charlotte

AU - Ritz, Christian

AU - Frøkiær, Hanne

AU - Smith, Taryn J

AU - Hart, Kathryn

AU - Lanham-New, Susan A

AU - Damsgaard, Camilla Trab

N1 - CURIS 2018 NEXS 205

PY - 2018

Y1 - 2018

N2 - Background: Low serum 25-hydroxyvitamin D [25(OH)D] has been associated with unfavorable cardiometabolic risk profiles in many observational studies in children, but very few randomized controlled trials have investigated this.Objective: We explored the effect of winter-time cholecalciferol (vitamin D3) supplementation on cardiometabolic risk markers in young, white, 4- to 8-y-old healthy Danish children (55°N) as part of the pan-European ODIN project.Methods: In the ODIN Junior double-blind, placebo-controlled, dose-response trial, 119 children (mean ± SD age: 6.7 ± 1.5 y; 36% male; 82% normal weight) were randomly allocated to 0, 10 or 20 µg/d of vitamin D3 for 20 wk (October-March). Cardiometabolic risk markers including BMI-for-age z score (BMIz), waist circumference, systolic and diastolic blood pressure, serum triglycerides and cholesterol (total, LDL, HDL, and total:HDL), plasma glucose and insulin, and whole-blood glycated hemoglobin were measured at baseline and endpoint as secondary outcomes together with serum 25(OH)D. Intervention effects were evaluated in linear regression models as between-group differences at endpoint adjusted for baseline value of the outcome, and additionally for age, sex, baseline serum 25(OH)D, BMIz, time since breakfast, and breakfast content.Results: Mean ± SD serum 25(OH)D was 56.7 ± 12.3 nmol/L at baseline and differed between groups at endpoint with concentrations of 31.1 ± 7.5, 61.8 ± 10.6, and 75.8 ± 11.5 nmol/L in the 0-, 10-, and 20 µg/d groups, respectively (P < 0.0001). Vitamin D3 supplementation had no effect on any of the cardiometabolic risk markers in analyses adjusted for baseline value of the outcome (all P ≥ 0.05), and additional covariate adjustment did not change the results notably.Conclusions: Preventing the winter decline in serum 25(OH)D with daily vitamin D3 supplementation of 10 or 20 µg had no cardiometabolic effects in healthy 4- to 8-y-old Danish children. This trial was registered at www.clinicaltrials.gov as NCT02145195.

AB - Background: Low serum 25-hydroxyvitamin D [25(OH)D] has been associated with unfavorable cardiometabolic risk profiles in many observational studies in children, but very few randomized controlled trials have investigated this.Objective: We explored the effect of winter-time cholecalciferol (vitamin D3) supplementation on cardiometabolic risk markers in young, white, 4- to 8-y-old healthy Danish children (55°N) as part of the pan-European ODIN project.Methods: In the ODIN Junior double-blind, placebo-controlled, dose-response trial, 119 children (mean ± SD age: 6.7 ± 1.5 y; 36% male; 82% normal weight) were randomly allocated to 0, 10 or 20 µg/d of vitamin D3 for 20 wk (October-March). Cardiometabolic risk markers including BMI-for-age z score (BMIz), waist circumference, systolic and diastolic blood pressure, serum triglycerides and cholesterol (total, LDL, HDL, and total:HDL), plasma glucose and insulin, and whole-blood glycated hemoglobin were measured at baseline and endpoint as secondary outcomes together with serum 25(OH)D. Intervention effects were evaluated in linear regression models as between-group differences at endpoint adjusted for baseline value of the outcome, and additionally for age, sex, baseline serum 25(OH)D, BMIz, time since breakfast, and breakfast content.Results: Mean ± SD serum 25(OH)D was 56.7 ± 12.3 nmol/L at baseline and differed between groups at endpoint with concentrations of 31.1 ± 7.5, 61.8 ± 10.6, and 75.8 ± 11.5 nmol/L in the 0-, 10-, and 20 µg/d groups, respectively (P < 0.0001). Vitamin D3 supplementation had no effect on any of the cardiometabolic risk markers in analyses adjusted for baseline value of the outcome (all P ≥ 0.05), and additional covariate adjustment did not change the results notably.Conclusions: Preventing the winter decline in serum 25(OH)D with daily vitamin D3 supplementation of 10 or 20 µg had no cardiometabolic effects in healthy 4- to 8-y-old Danish children. This trial was registered at www.clinicaltrials.gov as NCT02145195.

KW - The Faculty of Science

KW - Randomized controlled trial

KW - Vitamin D

KW - Cardiovascular risk factors

KW - Children

KW - ODIN

U2 - 10.1093/jn/nxy080

DO - 10.1093/jn/nxy080

M3 - Journal article

VL - 148

SP - 1261

EP - 1268

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 8

ER -

ID: 198226253