Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia. / Sigh, Sanne; Lauritzen, Lotte; Wieringa, Frank T; Laillou, Arnaud; Chamnan, Chhoun; Angkeabos, Nheb; Moniboth, Duch; Berger, Jacques; Stark, Ken D; Roos, Nanna.

I: Public Health Nutrition, Bind 23, Nr. 6, 2020, s. 974-986.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Sigh, S, Lauritzen, L, Wieringa, FT, Laillou, A, Chamnan, C, Angkeabos, N, Moniboth, D, Berger, J, Stark, KD & Roos, N 2020, 'Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia', Public Health Nutrition, bind 23, nr. 6, s. 974-986. https://doi.org/10.1017/S1368980019003744

APA

Sigh, S., Lauritzen, L., Wieringa, F. T., Laillou, A., Chamnan, C., Angkeabos, N., ... Roos, N. (2020). Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia. Public Health Nutrition, 23(6), 974-986. https://doi.org/10.1017/S1368980019003744

Vancouver

Sigh S, Lauritzen L, Wieringa FT, Laillou A, Chamnan C, Angkeabos N o.a. Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia. Public Health Nutrition. 2020;23(6):974-986. https://doi.org/10.1017/S1368980019003744

Author

Sigh, Sanne ; Lauritzen, Lotte ; Wieringa, Frank T ; Laillou, Arnaud ; Chamnan, Chhoun ; Angkeabos, Nheb ; Moniboth, Duch ; Berger, Jacques ; Stark, Ken D ; Roos, Nanna. / Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia. I: Public Health Nutrition. 2020 ; Bind 23, Nr. 6. s. 974-986.

Bibtex

@article{b370851201664dc6b19429c375ac6af4,
title = "Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia",
abstract = "Objective: To measure fatty acid composition, particularly whole-blood PUFA content, in acutely malnourished children and identify associations with markers of nutritional and health status.Design: PUFA were assessed in dried blood spots obtained from a cross-sectional study. Nutritional and health status were assessed by anthropometry, haemoglobinopathies, inflammation and blood counts.Setting: Cambodia.Participants: The study was conducted with 174 children aged 0·5-18 years with acute malnutrition. Results: Among total fatty acids (FA), the relative percentage of total PUFA was 20 {\%} FA, with 14 {\%} of the children having very low PUFA (mead acid (MA):arachidonic acid (AA) >0·02, n-6 docosapentaenoic acid:DHA >0·2 and total n-6:n-3 PUFA >10·5). Wasting was not associated with any PUFA. Stunting and low height were consistently positively associated with total PUFA and positively with n-6 PUFA. Height was positively associated with n-3 long-chain PUFA (LCPUFA). The presence of haemoglobinopathies or inflammation was positively associated with MA:AA, but not total PUFA. Elevated blood platelet counts were positively correlated with linoleic acid and appeared to be influenced by anaemia (P = 0·010) and inflammation (P = 0·002). Monocyte counts were high during inflammation (P = 0·052) and correlated positively with n-6 LCPUFA and n-3 LCPUFA. Conclusions: Children with acute malnutrition or stunting had low PUFA, while elevated platelets and monocytes were associated with high PUFA. In acutely malnourished children, inflammation could lead to elevated blood cell counts resulting in increased whole-blood PUFA which does not reflect dietary intake or nutritional status.",
keywords = "Acutely malnourished children, Blood cell counts, Inflammation, Nutritional status, PUFA",
author = "Sanne Sigh and Lotte Lauritzen and Wieringa, {Frank T} and Arnaud Laillou and Chhoun Chamnan and Nheb Angkeabos and Duch Moniboth and Jacques Berger and Stark, {Ken D} and Nanna Roos",
note = "CURIS 2020 NEXS 070",
year = "2020",
doi = "10.1017/S1368980019003744",
language = "English",
volume = "23",
pages = "974--986",
journal = "Public Health Nutrition",
issn = "1368-9800",
publisher = "Cambridge University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia

AU - Sigh, Sanne

AU - Lauritzen, Lotte

AU - Wieringa, Frank T

AU - Laillou, Arnaud

AU - Chamnan, Chhoun

AU - Angkeabos, Nheb

AU - Moniboth, Duch

AU - Berger, Jacques

AU - Stark, Ken D

AU - Roos, Nanna

N1 - CURIS 2020 NEXS 070

PY - 2020

Y1 - 2020

N2 - Objective: To measure fatty acid composition, particularly whole-blood PUFA content, in acutely malnourished children and identify associations with markers of nutritional and health status.Design: PUFA were assessed in dried blood spots obtained from a cross-sectional study. Nutritional and health status were assessed by anthropometry, haemoglobinopathies, inflammation and blood counts.Setting: Cambodia.Participants: The study was conducted with 174 children aged 0·5-18 years with acute malnutrition. Results: Among total fatty acids (FA), the relative percentage of total PUFA was 20 % FA, with 14 % of the children having very low PUFA (mead acid (MA):arachidonic acid (AA) >0·02, n-6 docosapentaenoic acid:DHA >0·2 and total n-6:n-3 PUFA >10·5). Wasting was not associated with any PUFA. Stunting and low height were consistently positively associated with total PUFA and positively with n-6 PUFA. Height was positively associated with n-3 long-chain PUFA (LCPUFA). The presence of haemoglobinopathies or inflammation was positively associated with MA:AA, but not total PUFA. Elevated blood platelet counts were positively correlated with linoleic acid and appeared to be influenced by anaemia (P = 0·010) and inflammation (P = 0·002). Monocyte counts were high during inflammation (P = 0·052) and correlated positively with n-6 LCPUFA and n-3 LCPUFA. Conclusions: Children with acute malnutrition or stunting had low PUFA, while elevated platelets and monocytes were associated with high PUFA. In acutely malnourished children, inflammation could lead to elevated blood cell counts resulting in increased whole-blood PUFA which does not reflect dietary intake or nutritional status.

AB - Objective: To measure fatty acid composition, particularly whole-blood PUFA content, in acutely malnourished children and identify associations with markers of nutritional and health status.Design: PUFA were assessed in dried blood spots obtained from a cross-sectional study. Nutritional and health status were assessed by anthropometry, haemoglobinopathies, inflammation and blood counts.Setting: Cambodia.Participants: The study was conducted with 174 children aged 0·5-18 years with acute malnutrition. Results: Among total fatty acids (FA), the relative percentage of total PUFA was 20 % FA, with 14 % of the children having very low PUFA (mead acid (MA):arachidonic acid (AA) >0·02, n-6 docosapentaenoic acid:DHA >0·2 and total n-6:n-3 PUFA >10·5). Wasting was not associated with any PUFA. Stunting and low height were consistently positively associated with total PUFA and positively with n-6 PUFA. Height was positively associated with n-3 long-chain PUFA (LCPUFA). The presence of haemoglobinopathies or inflammation was positively associated with MA:AA, but not total PUFA. Elevated blood platelet counts were positively correlated with linoleic acid and appeared to be influenced by anaemia (P = 0·010) and inflammation (P = 0·002). Monocyte counts were high during inflammation (P = 0·052) and correlated positively with n-6 LCPUFA and n-3 LCPUFA. Conclusions: Children with acute malnutrition or stunting had low PUFA, while elevated platelets and monocytes were associated with high PUFA. In acutely malnourished children, inflammation could lead to elevated blood cell counts resulting in increased whole-blood PUFA which does not reflect dietary intake or nutritional status.

KW - Acutely malnourished children

KW - Blood cell counts

KW - Inflammation

KW - Nutritional status

KW - PUFA

U2 - 10.1017/S1368980019003744

DO - 10.1017/S1368980019003744

M3 - Journal article

C2 - 31973779

AN - SCOPUS:85078476953

VL - 23

SP - 974

EP - 986

JO - Public Health Nutrition

JF - Public Health Nutrition

SN - 1368-9800

IS - 6

ER -

ID: 235966159