Vitamin D status is associated with cardiometabolic markers in 8-11-year-old children, independently of body fat and physical activity

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Standard

Vitamin D status is associated with cardiometabolic markers in 8-11-year-old children, independently of body fat and physical activity. / Petersen, Rikke Agnete; Dalskov, Stine-Mathilde; Sørensen, Louise B; Hjorth, Mads Fiil; Andersen, Rikke; Tetens, Inge; Krarup, Henrik; Ritz, Christian; Astrup, Arne; Michaelsen, Kim F.; Mølgaard, Christian; Damsgaard, Camilla Trab.

I: British Journal of Nutrition, Bind 114, Nr. 10, 2015, s. 1647-1655.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Petersen, RA, Dalskov, S-M, Sørensen, LB, Hjorth, MF, Andersen, R, Tetens, I, Krarup, H, Ritz, C, Astrup, A, Michaelsen, KF, Mølgaard, C & Damsgaard, CT 2015, 'Vitamin D status is associated with cardiometabolic markers in 8-11-year-old children, independently of body fat and physical activity', British Journal of Nutrition, bind 114, nr. 10, s. 1647-1655. https://doi.org/10.1017/S0007114515003372

APA

Petersen, R. A., Dalskov, S-M., Sørensen, L. B., Hjorth, M. F., Andersen, R., Tetens, I., ... Damsgaard, C. T. (2015). Vitamin D status is associated with cardiometabolic markers in 8-11-year-old children, independently of body fat and physical activity. British Journal of Nutrition, 114(10), 1647-1655. https://doi.org/10.1017/S0007114515003372

Vancouver

Petersen RA, Dalskov S-M, Sørensen LB, Hjorth MF, Andersen R, Tetens I o.a. Vitamin D status is associated with cardiometabolic markers in 8-11-year-old children, independently of body fat and physical activity. British Journal of Nutrition. 2015;114(10):1647-1655. https://doi.org/10.1017/S0007114515003372

Author

Petersen, Rikke Agnete ; Dalskov, Stine-Mathilde ; Sørensen, Louise B ; Hjorth, Mads Fiil ; Andersen, Rikke ; Tetens, Inge ; Krarup, Henrik ; Ritz, Christian ; Astrup, Arne ; Michaelsen, Kim F. ; Mølgaard, Christian ; Damsgaard, Camilla Trab. / Vitamin D status is associated with cardiometabolic markers in 8-11-year-old children, independently of body fat and physical activity. I: British Journal of Nutrition. 2015 ; Bind 114, Nr. 10. s. 1647-1655.

Bibtex

@article{3c4b4422f7b641d4ae47133beac704f0,
title = "Vitamin D status is associated with cardiometabolic markers in 8-11-year-old children, independently of body fat and physical activity",
abstract = "Vitamin D status has been associated with cardiometabolic markers even in children, but the associations may be confounded by fat mass and physical activity behaviour. This study investigated associations between vitamin D status and cardiometabolic risk profile, as well as the impact of fat mass and physical activity in Danish 8-11-year-old children, using baseline data from 782 children participating in the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study. We assessed vitamin D status as serum 25-hydroxyvitamin D (25(OH)D) and measured blood pressure, fasting plasma glucose, homoeostasis model of assessment-insulin resistance, plasma lipids, inflammatory markers, anthropometry and fat mass by dual-energy X-ray absorptiometry, and physical activity by 7 d accelerometry during August-November. Mean serum 25(OH)D was 60·8 (sd 18·7) nmol/l. Each 10 mmol/l 25(OH)D increase was associated with lower diastolic blood pressure (-0·3 mmHg, 95 {\%} CI -0·6, -0·0) (P=0·02), total cholesterol (-0·07 mmol/l, 95 {\%} CI -0·10, -0·05), LDL-cholesterol (-0·05 mmol/l, 95 {\%} CI -0·08, -0·03), TAG (-0·02 mmol/l, 95 {\%} CI -0·03, -0·01) (P≤0·001 for all lipids) and lower metabolic syndrome (MetS) score (P=0·01). Adjustment for fat mass index did not change the associations, but the association with blood pressure became borderline significant after adjustment for physical activity (P=0·06). In conclusion, vitamin D status was negatively associated with blood pressure, plasma lipids and a MetS score in Danish school children with low prevalence of vitamin D deficiency, and apart from blood pressure the associations were independent of body fat and physical activity. The potential underlying cause-effect relationship and possible long-term implications should be investigated in randomised controlled trials.",
author = "Petersen, {Rikke Agnete} and Stine-Mathilde Dalskov and S{\o}rensen, {Louise B} and Hjorth, {Mads Fiil} and Rikke Andersen and Inge Tetens and Henrik Krarup and Christian Ritz and Arne Astrup and Michaelsen, {Kim F.} and Christian M{\o}lgaard and Damsgaard, {Camilla Trab}",
note = "CURIS 2015 NEXS 341",
year = "2015",
doi = "10.1017/S0007114515003372",
language = "English",
volume = "114",
pages = "1647--1655",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Vitamin D status is associated with cardiometabolic markers in 8-11-year-old children, independently of body fat and physical activity

AU - Petersen, Rikke Agnete

AU - Dalskov, Stine-Mathilde

AU - Sørensen, Louise B

AU - Hjorth, Mads Fiil

AU - Andersen, Rikke

AU - Tetens, Inge

AU - Krarup, Henrik

AU - Ritz, Christian

AU - Astrup, Arne

AU - Michaelsen, Kim F.

AU - Mølgaard, Christian

AU - Damsgaard, Camilla Trab

N1 - CURIS 2015 NEXS 341

PY - 2015

Y1 - 2015

N2 - Vitamin D status has been associated with cardiometabolic markers even in children, but the associations may be confounded by fat mass and physical activity behaviour. This study investigated associations between vitamin D status and cardiometabolic risk profile, as well as the impact of fat mass and physical activity in Danish 8-11-year-old children, using baseline data from 782 children participating in the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study. We assessed vitamin D status as serum 25-hydroxyvitamin D (25(OH)D) and measured blood pressure, fasting plasma glucose, homoeostasis model of assessment-insulin resistance, plasma lipids, inflammatory markers, anthropometry and fat mass by dual-energy X-ray absorptiometry, and physical activity by 7 d accelerometry during August-November. Mean serum 25(OH)D was 60·8 (sd 18·7) nmol/l. Each 10 mmol/l 25(OH)D increase was associated with lower diastolic blood pressure (-0·3 mmHg, 95 % CI -0·6, -0·0) (P=0·02), total cholesterol (-0·07 mmol/l, 95 % CI -0·10, -0·05), LDL-cholesterol (-0·05 mmol/l, 95 % CI -0·08, -0·03), TAG (-0·02 mmol/l, 95 % CI -0·03, -0·01) (P≤0·001 for all lipids) and lower metabolic syndrome (MetS) score (P=0·01). Adjustment for fat mass index did not change the associations, but the association with blood pressure became borderline significant after adjustment for physical activity (P=0·06). In conclusion, vitamin D status was negatively associated with blood pressure, plasma lipids and a MetS score in Danish school children with low prevalence of vitamin D deficiency, and apart from blood pressure the associations were independent of body fat and physical activity. The potential underlying cause-effect relationship and possible long-term implications should be investigated in randomised controlled trials.

AB - Vitamin D status has been associated with cardiometabolic markers even in children, but the associations may be confounded by fat mass and physical activity behaviour. This study investigated associations between vitamin D status and cardiometabolic risk profile, as well as the impact of fat mass and physical activity in Danish 8-11-year-old children, using baseline data from 782 children participating in the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study. We assessed vitamin D status as serum 25-hydroxyvitamin D (25(OH)D) and measured blood pressure, fasting plasma glucose, homoeostasis model of assessment-insulin resistance, plasma lipids, inflammatory markers, anthropometry and fat mass by dual-energy X-ray absorptiometry, and physical activity by 7 d accelerometry during August-November. Mean serum 25(OH)D was 60·8 (sd 18·7) nmol/l. Each 10 mmol/l 25(OH)D increase was associated with lower diastolic blood pressure (-0·3 mmHg, 95 % CI -0·6, -0·0) (P=0·02), total cholesterol (-0·07 mmol/l, 95 % CI -0·10, -0·05), LDL-cholesterol (-0·05 mmol/l, 95 % CI -0·08, -0·03), TAG (-0·02 mmol/l, 95 % CI -0·03, -0·01) (P≤0·001 for all lipids) and lower metabolic syndrome (MetS) score (P=0·01). Adjustment for fat mass index did not change the associations, but the association with blood pressure became borderline significant after adjustment for physical activity (P=0·06). In conclusion, vitamin D status was negatively associated with blood pressure, plasma lipids and a MetS score in Danish school children with low prevalence of vitamin D deficiency, and apart from blood pressure the associations were independent of body fat and physical activity. The potential underlying cause-effect relationship and possible long-term implications should be investigated in randomised controlled trials.

U2 - 10.1017/S0007114515003372

DO - 10.1017/S0007114515003372

M3 - Journal article

VL - 114

SP - 1647

EP - 1655

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 10

ER -

ID: 144414378