Utility of bio-electrical impedance vector analysis for monitoring treatment of severe acute malnutrition in children

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Utility of bio-electrical impedance vector analysis for monitoring treatment of severe acute malnutrition in children. / Girma, Tsinuel; Kæstel, Pernille; Mølgaard, Christian; Ritz, Christian; Andersen, Gregers Stig; Michaelsen, Kim F.; Friis, Henrik; Wells, Jonathan CK.

I: Clinical Nutrition, 24.06.2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Girma, T, Kæstel, P, Mølgaard, C, Ritz, C, Andersen, GS, Michaelsen, KF, Friis, H & Wells, JCK 2020, 'Utility of bio-electrical impedance vector analysis for monitoring treatment of severe acute malnutrition in children', Clinical Nutrition. https://doi.org/10.1016/j.clnu.2020.06.012

APA

Girma, T., Kæstel, P., Mølgaard, C., Ritz, C., Andersen, G. S., Michaelsen, K. F., ... Wells, J. CK. (2020). Utility of bio-electrical impedance vector analysis for monitoring treatment of severe acute malnutrition in children. Clinical Nutrition. https://doi.org/10.1016/j.clnu.2020.06.012

Vancouver

Girma T, Kæstel P, Mølgaard C, Ritz C, Andersen GS, Michaelsen KF o.a. Utility of bio-electrical impedance vector analysis for monitoring treatment of severe acute malnutrition in children. Clinical Nutrition. 2020 jun 24. https://doi.org/10.1016/j.clnu.2020.06.012

Author

Girma, Tsinuel ; Kæstel, Pernille ; Mølgaard, Christian ; Ritz, Christian ; Andersen, Gregers Stig ; Michaelsen, Kim F. ; Friis, Henrik ; Wells, Jonathan CK. / Utility of bio-electrical impedance vector analysis for monitoring treatment of severe acute malnutrition in children. I: Clinical Nutrition. 2020.

Bibtex

@article{b0d24f16498c4dd7a5954c53b5c62276,
title = "Utility of bio-electrical impedance vector analysis for monitoring treatment of severe acute malnutrition in children",
abstract = "Background & aims: Change in hydration is common in children with severe acute malnutrition (SAM) including during treatment, but is difficult to assess. We investigated the utility of bio-electrical impedance vector analysis (BIVA), a quick non-invasive method, for indexing hydration during treatment.Methods: We studied 350 children 0·5-14 years of age with SAM (mid-upper arm circumference <11·0 cm or weight-for-height <70{\%} of median, and/or nutritional oedema) admitted to a hospital nutrition unit, but excluded medically unstable patients. Weight, height (H), resistance (R), reactance (Xc) and phase angle (PA) were measured and oedema assessed. Similar data were collected from 120 healthy infants and preschool/school children for comparison. Means of height-adjusted vectors (R/H, Xc/H) from SAM children were interpreted using tolerance and confidence ellipses of corresponding parameters from the healthy children.Results: SAM children with oedema were less wasted than those without (p < 0·001), but had BIVA parameters that differed more from those of healthy children (P < 0·05) than those non-oedematous. Initially, both oedematous and non-oedematous SAM children had mean vectors outside the reference 95{\%} tolerance ellipse. During treatment, mean vectors migrated differently in the two SAM groups, indicating fluid loss in oedematous patients, and tissue accretion in non-oedematous patients. At admission, R/H was lower (oedematous) or higher (non-oedematous) among children who died than those who exited the hospital alive.Conclusions: BIVA can be used in children with SAM to distinguish tissue-vs. hydration-related weight changes during treatment, and also identify children at high risk of death enabling early clinical interventions.",
keywords = "Faculty of Science, Bio-electrical impedance, BIVA, Severe acute malnutrition, Hydration",
author = "Tsinuel Girma and Pernille K{\ae}stel and Christian M{\o}lgaard and Christian Ritz and Andersen, {Gregers Stig} and Michaelsen, {Kim F.} and Henrik Friis and Wells, {Jonathan CK}",
note = "Copyright {\circledC} 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.",
year = "2020",
month = "6",
day = "24",
doi = "10.1016/j.clnu.2020.06.012",
language = "English",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Utility of bio-electrical impedance vector analysis for monitoring treatment of severe acute malnutrition in children

AU - Girma, Tsinuel

AU - Kæstel, Pernille

AU - Mølgaard, Christian

AU - Ritz, Christian

AU - Andersen, Gregers Stig

AU - Michaelsen, Kim F.

AU - Friis, Henrik

AU - Wells, Jonathan CK

N1 - Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

PY - 2020/6/24

Y1 - 2020/6/24

N2 - Background & aims: Change in hydration is common in children with severe acute malnutrition (SAM) including during treatment, but is difficult to assess. We investigated the utility of bio-electrical impedance vector analysis (BIVA), a quick non-invasive method, for indexing hydration during treatment.Methods: We studied 350 children 0·5-14 years of age with SAM (mid-upper arm circumference <11·0 cm or weight-for-height <70% of median, and/or nutritional oedema) admitted to a hospital nutrition unit, but excluded medically unstable patients. Weight, height (H), resistance (R), reactance (Xc) and phase angle (PA) were measured and oedema assessed. Similar data were collected from 120 healthy infants and preschool/school children for comparison. Means of height-adjusted vectors (R/H, Xc/H) from SAM children were interpreted using tolerance and confidence ellipses of corresponding parameters from the healthy children.Results: SAM children with oedema were less wasted than those without (p < 0·001), but had BIVA parameters that differed more from those of healthy children (P < 0·05) than those non-oedematous. Initially, both oedematous and non-oedematous SAM children had mean vectors outside the reference 95% tolerance ellipse. During treatment, mean vectors migrated differently in the two SAM groups, indicating fluid loss in oedematous patients, and tissue accretion in non-oedematous patients. At admission, R/H was lower (oedematous) or higher (non-oedematous) among children who died than those who exited the hospital alive.Conclusions: BIVA can be used in children with SAM to distinguish tissue-vs. hydration-related weight changes during treatment, and also identify children at high risk of death enabling early clinical interventions.

AB - Background & aims: Change in hydration is common in children with severe acute malnutrition (SAM) including during treatment, but is difficult to assess. We investigated the utility of bio-electrical impedance vector analysis (BIVA), a quick non-invasive method, for indexing hydration during treatment.Methods: We studied 350 children 0·5-14 years of age with SAM (mid-upper arm circumference <11·0 cm or weight-for-height <70% of median, and/or nutritional oedema) admitted to a hospital nutrition unit, but excluded medically unstable patients. Weight, height (H), resistance (R), reactance (Xc) and phase angle (PA) were measured and oedema assessed. Similar data were collected from 120 healthy infants and preschool/school children for comparison. Means of height-adjusted vectors (R/H, Xc/H) from SAM children were interpreted using tolerance and confidence ellipses of corresponding parameters from the healthy children.Results: SAM children with oedema were less wasted than those without (p < 0·001), but had BIVA parameters that differed more from those of healthy children (P < 0·05) than those non-oedematous. Initially, both oedematous and non-oedematous SAM children had mean vectors outside the reference 95% tolerance ellipse. During treatment, mean vectors migrated differently in the two SAM groups, indicating fluid loss in oedematous patients, and tissue accretion in non-oedematous patients. At admission, R/H was lower (oedematous) or higher (non-oedematous) among children who died than those who exited the hospital alive.Conclusions: BIVA can be used in children with SAM to distinguish tissue-vs. hydration-related weight changes during treatment, and also identify children at high risk of death enabling early clinical interventions.

KW - Faculty of Science

KW - Bio-electrical impedance

KW - BIVA

KW - Severe acute malnutrition

KW - Hydration

U2 - 10.1016/j.clnu.2020.06.012

DO - 10.1016/j.clnu.2020.06.012

M3 - Journal article

C2 - 32698958

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

ER -

ID: 245229773