Undiagnosed diabetes mellitus in community-acquired pneumonia: A prospective cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Andreas Vestergaard Jensen, Daniel Faurholt-Jepsen, Gertrud Baunbæk Egelund, Stine Bang Andersen, Pelle Trier Petersen, Thomas Benfield, Martin Witzenrath, Gernot Rohde, Pernille Ravn, German Community-Acquired Pneumonia Competence Network (CAPNETZ)

Background: Diabetes mellitus is an important risk factor for community-acquired pneumonia, whereas the prevalence of undiagnosed diabetes mellitus and prediabetes in patients with community-acquired pneumonia is largely unknown. We aimed to determine the prevalence of prediabetes, undiagnosed diabetes mellitus, and risk factors associated with undiagnosed diabetes mellitus in a large European community-acquired pneumonia cohort.

Methods: This was a multicenter prospective cohort study of hospitals and private practices in Germany and Austria encompassing 1961 adults with community-acquired pneumonia included in the German Community-Acquired Pneumonia Competence Network (CAPNETZ) study between 2007 and 2014. The prevalence of undiagnosed diabetes mellitus and prediabetes was estimated based on hemoglobin A1c measurements. Logistic regression was used to assess risk factors for undiagnosed diabetes mellitus.

Results: Fifteen percent of patients had known diabetes mellitus. Among patients without known diabetes mellitus, 5.0% had undiagnosed diabetes mellitus and 37.5% had prediabetes. Male sex (odds ratio [OR], 2.45 [95% confidence interval {CI}, 1.35-4.45]), body mass index ≥25 kg/m2 (OR, 2.64 [95% CI, 1.48-4.72]), and hyperglycemia at admission (6-11 mM: OR, 2.93 [95% CI, 1.54-5.60] and ≥11 mM: OR, 44.76 [95% CI, 17.58-113.98]) were associated with undiagnosed diabetes mellitus. Patients with undiagnosed diabetes mellitus had a higher 180-day mortality rate compared to patients without diabetes mellitus (12.1% vs 3.8%, respectively; P = .001).

Conclusions: Undiagnosed diabetes mellitus was prevalent among community-acquired pneumonia. Male sex, overweight, and hyperglycemia at admission were associated with undiagnosed diabetes mellitus. The long-term mortality among patients with undiagnosed diabetes mellitus was high compared to patients without diabetes mellitus.

OriginalsprogEngelsk
TidsskriftClinical Infectious Diseases
Vol/bind65
Udgave nummer12
Sider (fra-til)2091-2098
Antal sider8
ISSN1058-4838
DOI
StatusUdgivet - 2017

Bibliografisk note

CURIS 2017 NEXS 390

ID: 193665631