The role of leptin and other hormones related to bone metabolism and appetite-regulation as determinants of gain in body fat and fat-free mass in 8-11 year old children

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Standard

The role of leptin and other hormones related to bone metabolism and appetite-regulation as determinants of gain in body fat and fat-free mass in 8-11 year old children. / Dalskov, Stine-Mathilde; Ritz, Christian; Larnkjær, Anni; Damsgaard, Camilla Trab; Petersen, Rikke Agnete; Sørensen, Louise Bergmann; Ong, Ken K; Astrup, Arne; Mølgaard, Christian; Michaelsen, Kim F.

I: Journal of Clinical Endocrinology and Metabolism, Bind 100, Nr. 3, 2015, s. 1196-1205.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Dalskov, S-M, Ritz, C, Larnkjær, A, Damsgaard, CT, Petersen, RA, Sørensen, LB, Ong, KK, Astrup, A, Mølgaard, C & Michaelsen, KF 2015, 'The role of leptin and other hormones related to bone metabolism and appetite-regulation as determinants of gain in body fat and fat-free mass in 8-11 year old children', Journal of Clinical Endocrinology and Metabolism, bind 100, nr. 3, s. 1196-1205. https://doi.org/10.1210/jc.2014-3706

APA

Dalskov, S-M., Ritz, C., Larnkjær, A., Damsgaard, C. T., Petersen, R. A., Sørensen, L. B., ... Michaelsen, K. F. (2015). The role of leptin and other hormones related to bone metabolism and appetite-regulation as determinants of gain in body fat and fat-free mass in 8-11 year old children. Journal of Clinical Endocrinology and Metabolism, 100(3), 1196-1205. https://doi.org/10.1210/jc.2014-3706

Vancouver

Dalskov S-M, Ritz C, Larnkjær A, Damsgaard CT, Petersen RA, Sørensen LB o.a. The role of leptin and other hormones related to bone metabolism and appetite-regulation as determinants of gain in body fat and fat-free mass in 8-11 year old children. Journal of Clinical Endocrinology and Metabolism. 2015;100(3):1196-1205. https://doi.org/10.1210/jc.2014-3706

Author

Dalskov, Stine-Mathilde ; Ritz, Christian ; Larnkjær, Anni ; Damsgaard, Camilla Trab ; Petersen, Rikke Agnete ; Sørensen, Louise Bergmann ; Ong, Ken K ; Astrup, Arne ; Mølgaard, Christian ; Michaelsen, Kim F. / The role of leptin and other hormones related to bone metabolism and appetite-regulation as determinants of gain in body fat and fat-free mass in 8-11 year old children. I: Journal of Clinical Endocrinology and Metabolism. 2015 ; Bind 100, Nr. 3. s. 1196-1205.

Bibtex

@article{9ac6af65d7f74c0390539528dc46851f,
title = "The role of leptin and other hormones related to bone metabolism and appetite-regulation as determinants of gain in body fat and fat-free mass in 8-11 year old children",
abstract = "Background: Regulation of body composition during childhood is complex. Numerous hormones are potentially involved. Leptin has been proposed to restrain weight gain, but results are inconsistent. Objectives: We examined if baseline fasting levels of ghrelin, adiponectin, leptin, insulin, insulin-like growth factor I (IGF-1), osteocalcin and intact parathyroid hormone (iPTH) were associated with body composition cross-sectionally and longitudinally in 633 8-11-year-olds. Design: Data on hormones and body composition by Dual-energy X-ray absorptiometry from OPUS School Meal Study were used. We looked at baseline hormones as predictors of baseline fat mass index (FMI) or fat-free mass index (FFMI), and also subsequent changes (three and six months) in FMI or FFMI using models with hormones individually or combined. Results: Cross-sectionally, baseline leptin was positively associated with FMI in girls (0.211 kg/m(2) pr. μg/ml (0.186; 0.236), p<0.001) and boys (0.231 kg/m(2) pr. μg/ml (0.200; 0.261), p<0.001). IGF-1 in both genders and iPTH in boys were positively associated with FMI. An inverse association between adiponectin and FFMI in boys and a positive association between IGF-1 and FFMI in girls were found. In longitudinal models, baseline leptin was inversely associated with subsequent changes in FMI (-0.018 kg/m(2) pr. μg/ml (-0.034; -0.002), p=0.028) and FFMI (-0.014 kg/m(2) pr. μg/ml (-0.024; -0.003), p=0.006) in girls. Conclusions: Cross-sectional findings support that leptin is produced in proportion to body fat mass, but the longitudinal observations support that leptin inhibits gains in FMI and FFMI in girls, a finding which may reflect preserved leptin sensitivity in this predominantly normal weight population.",
author = "Stine-Mathilde Dalskov and Christian Ritz and Anni Larnkj{\ae}r and Damsgaard, {Camilla Trab} and Petersen, {Rikke Agnete} and S{\o}rensen, {Louise Bergmann} and Ong, {Ken K} and Arne Astrup and Christian M{\o}lgaard and Michaelsen, {Kim F.}",
note = "CURIS 2015 NEXS 021",
year = "2015",
doi = "10.1210/jc.2014-3706",
language = "English",
volume = "100",
pages = "1196--1205",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - The role of leptin and other hormones related to bone metabolism and appetite-regulation as determinants of gain in body fat and fat-free mass in 8-11 year old children

AU - Dalskov, Stine-Mathilde

AU - Ritz, Christian

AU - Larnkjær, Anni

AU - Damsgaard, Camilla Trab

AU - Petersen, Rikke Agnete

AU - Sørensen, Louise Bergmann

AU - Ong, Ken K

AU - Astrup, Arne

AU - Mølgaard, Christian

AU - Michaelsen, Kim F.

N1 - CURIS 2015 NEXS 021

PY - 2015

Y1 - 2015

N2 - Background: Regulation of body composition during childhood is complex. Numerous hormones are potentially involved. Leptin has been proposed to restrain weight gain, but results are inconsistent. Objectives: We examined if baseline fasting levels of ghrelin, adiponectin, leptin, insulin, insulin-like growth factor I (IGF-1), osteocalcin and intact parathyroid hormone (iPTH) were associated with body composition cross-sectionally and longitudinally in 633 8-11-year-olds. Design: Data on hormones and body composition by Dual-energy X-ray absorptiometry from OPUS School Meal Study were used. We looked at baseline hormones as predictors of baseline fat mass index (FMI) or fat-free mass index (FFMI), and also subsequent changes (three and six months) in FMI or FFMI using models with hormones individually or combined. Results: Cross-sectionally, baseline leptin was positively associated with FMI in girls (0.211 kg/m(2) pr. μg/ml (0.186; 0.236), p<0.001) and boys (0.231 kg/m(2) pr. μg/ml (0.200; 0.261), p<0.001). IGF-1 in both genders and iPTH in boys were positively associated with FMI. An inverse association between adiponectin and FFMI in boys and a positive association between IGF-1 and FFMI in girls were found. In longitudinal models, baseline leptin was inversely associated with subsequent changes in FMI (-0.018 kg/m(2) pr. μg/ml (-0.034; -0.002), p=0.028) and FFMI (-0.014 kg/m(2) pr. μg/ml (-0.024; -0.003), p=0.006) in girls. Conclusions: Cross-sectional findings support that leptin is produced in proportion to body fat mass, but the longitudinal observations support that leptin inhibits gains in FMI and FFMI in girls, a finding which may reflect preserved leptin sensitivity in this predominantly normal weight population.

AB - Background: Regulation of body composition during childhood is complex. Numerous hormones are potentially involved. Leptin has been proposed to restrain weight gain, but results are inconsistent. Objectives: We examined if baseline fasting levels of ghrelin, adiponectin, leptin, insulin, insulin-like growth factor I (IGF-1), osteocalcin and intact parathyroid hormone (iPTH) were associated with body composition cross-sectionally and longitudinally in 633 8-11-year-olds. Design: Data on hormones and body composition by Dual-energy X-ray absorptiometry from OPUS School Meal Study were used. We looked at baseline hormones as predictors of baseline fat mass index (FMI) or fat-free mass index (FFMI), and also subsequent changes (three and six months) in FMI or FFMI using models with hormones individually or combined. Results: Cross-sectionally, baseline leptin was positively associated with FMI in girls (0.211 kg/m(2) pr. μg/ml (0.186; 0.236), p<0.001) and boys (0.231 kg/m(2) pr. μg/ml (0.200; 0.261), p<0.001). IGF-1 in both genders and iPTH in boys were positively associated with FMI. An inverse association between adiponectin and FFMI in boys and a positive association between IGF-1 and FFMI in girls were found. In longitudinal models, baseline leptin was inversely associated with subsequent changes in FMI (-0.018 kg/m(2) pr. μg/ml (-0.034; -0.002), p=0.028) and FFMI (-0.014 kg/m(2) pr. μg/ml (-0.024; -0.003), p=0.006) in girls. Conclusions: Cross-sectional findings support that leptin is produced in proportion to body fat mass, but the longitudinal observations support that leptin inhibits gains in FMI and FFMI in girls, a finding which may reflect preserved leptin sensitivity in this predominantly normal weight population.

U2 - 10.1210/jc.2014-3706

DO - 10.1210/jc.2014-3706

M3 - Journal article

VL - 100

SP - 1196

EP - 1205

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -

ID: 129818609