Renal function and vitamin D level in HIV positive adults in Ethiopia: the effect of antiretroviral treatment and nutrition

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandling

  • Daniel Yilma Bogale
Limited information is available on the effect of nutritional supplementation on serum 25-hydroxyvitamin D (25(OH)D) level in HIV positive adults living in sub-Saharan Africa where there is sunshine throughout the year. Moreover, estimated glomerular filtration rate estimating (eGFR) equations using serum creatinine are not validated in most African settings and various results have been reported on the effect of antiretroviral treatment (ART) on kidney function.

In this PhD thesis, use of nutritional supplementation which contained vitamin D prevented a reduction in serum 25 (OH) D levels in HIV positive persons initiating ART. All eGFR equations overestimated 24-hr creatinine clearance in the HIV positive persons. Moreover, HIV positive adults had relatively good kidney function at the initiation of ART in Ethiopia and remained stable over 12 months of ART with no significant difference in HIV positive persons treated with tenofovir disoproxil fumarate (TDF) and non TDF-based regimen
OriginalsprogEngelsk
ForlagDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
Antal sider151
StatusUdgivet - 2019

ID: 232136590