Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications

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Standard

Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications. / Weischendorff, Sarah; Kielsen, Katrine; Nederby, Maria; Svendsen, Lotte; Burrin, Douglas; Heilmann, Carsten; Ifversen, Marianne; Sengeløv, Henrik; Mølgaard, Christian; Müller, Klaus.

I: Biology of Blood and Marrow Transplantation, 23.04.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Weischendorff, S, Kielsen, K, Nederby, M, Svendsen, L, Burrin, D, Heilmann, C, Ifversen, M, Sengeløv, H, Mølgaard, C & Müller, K 2019, 'Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications' Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2019.03.018

APA

Weischendorff, S., Kielsen, K., Nederby, M., Svendsen, L., Burrin, D., Heilmann, C., ... Müller, K. (2019). Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications. Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2019.03.018

Vancouver

Weischendorff S, Kielsen K, Nederby M, Svendsen L, Burrin D, Heilmann C o.a. Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications. Biology of Blood and Marrow Transplantation. 2019 apr 23. https://doi.org/10.1016/j.bbmt.2019.03.018

Author

Weischendorff, Sarah ; Kielsen, Katrine ; Nederby, Maria ; Svendsen, Lotte ; Burrin, Douglas ; Heilmann, Carsten ; Ifversen, Marianne ; Sengeløv, Henrik ; Mølgaard, Christian ; Müller, Klaus. / Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications. I: Biology of Blood and Marrow Transplantation. 2019.

Bibtex

@article{a148a0cd00a8413b8727fc0fff23d093,
title = "Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications",
abstract = "Patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) are challenged by cytotoxic effects of the conditioning regimen, resulting in tissue damage, systemic inflammation and elevated metabolic demands for amino acids to regenerate damaged tissues, reconstitute hematopoietic cells, and establish antioxidant defenses. Few studies have addressed the role of plasma amino acid (PAA) levels during transplantation, and it remains unknown if amino acid deficiency can aggravate treatment-related morbidity. We determined plasma levels of the 23 human amino acids in 80 HSCT patients (age 1.1-55.4 years) before conditioning and on day +7 and +21 post-transplant along with C-reactive protein (CRP) and Interleukin 6 (IL-6) levels on day +7. Significant changes were observed in plasma concentrations of several human amino acids during HSCT. On day +7, several amino acids were inversely correlated with both CRP and IL-6, including glutamic acid, serine, alanine, glutamine, arginine, cysteine, glycine, histidine, lysine, tryptophan, threonine, taurine, proline, and methionine (r between -0.22 and -0.66, all p<0.05). Patients developing sinusoidal obstruction syndrome (SOS) had significantly lower total PAA levels compared to patients without SOS (2013 ng/l (1709-2318) vs 2706 ng/l (2261-3150), p=0.006) along with lower individual levels of glutamic acid, serine, arginine, glycine, lysine, valine, tryptophan, threonine, and proline (all p<0.05) on day +7. Patients with severe acute graft-versus-host disease had lower total PAA level (1922 ng/l (1738-2106) vs 2649 ng/l (2244-3055), p=0.014) and decreased levels of serine, glutamine, cysteine, glycine, lysine and threonine on day +7 (all p<0.05). These results indicate a relationship between low concentrations of certain amino acids and risk of treatment-related complications.",
keywords = "The Faculty of Science, Hematopoietic stem cell transplantation, Amino acids, Systemic inflammation, Sinusoidal obstruction syndrome, Acute graft-versus-host disease",
author = "Sarah Weischendorff and Katrine Kielsen and Maria Nederby and Lotte Svendsen and Douglas Burrin and Carsten Heilmann and Marianne Ifversen and Henrik Sengel{\o}v and Christian M{\o}lgaard and Klaus M{\"u}ller",
note = "CURIS 2019 NEXS 138 Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2019",
month = "4",
day = "23",
doi = "10.1016/j.bbmt.2019.03.018",
language = "English",
journal = "Biology of Blood and Marrow Transplantation",
issn = "1083-8791",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications

AU - Weischendorff, Sarah

AU - Kielsen, Katrine

AU - Nederby, Maria

AU - Svendsen, Lotte

AU - Burrin, Douglas

AU - Heilmann, Carsten

AU - Ifversen, Marianne

AU - Sengeløv, Henrik

AU - Mølgaard, Christian

AU - Müller, Klaus

N1 - CURIS 2019 NEXS 138 Copyright © 2019. Published by Elsevier Inc.

PY - 2019/4/23

Y1 - 2019/4/23

N2 - Patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) are challenged by cytotoxic effects of the conditioning regimen, resulting in tissue damage, systemic inflammation and elevated metabolic demands for amino acids to regenerate damaged tissues, reconstitute hematopoietic cells, and establish antioxidant defenses. Few studies have addressed the role of plasma amino acid (PAA) levels during transplantation, and it remains unknown if amino acid deficiency can aggravate treatment-related morbidity. We determined plasma levels of the 23 human amino acids in 80 HSCT patients (age 1.1-55.4 years) before conditioning and on day +7 and +21 post-transplant along with C-reactive protein (CRP) and Interleukin 6 (IL-6) levels on day +7. Significant changes were observed in plasma concentrations of several human amino acids during HSCT. On day +7, several amino acids were inversely correlated with both CRP and IL-6, including glutamic acid, serine, alanine, glutamine, arginine, cysteine, glycine, histidine, lysine, tryptophan, threonine, taurine, proline, and methionine (r between -0.22 and -0.66, all p<0.05). Patients developing sinusoidal obstruction syndrome (SOS) had significantly lower total PAA levels compared to patients without SOS (2013 ng/l (1709-2318) vs 2706 ng/l (2261-3150), p=0.006) along with lower individual levels of glutamic acid, serine, arginine, glycine, lysine, valine, tryptophan, threonine, and proline (all p<0.05) on day +7. Patients with severe acute graft-versus-host disease had lower total PAA level (1922 ng/l (1738-2106) vs 2649 ng/l (2244-3055), p=0.014) and decreased levels of serine, glutamine, cysteine, glycine, lysine and threonine on day +7 (all p<0.05). These results indicate a relationship between low concentrations of certain amino acids and risk of treatment-related complications.

AB - Patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) are challenged by cytotoxic effects of the conditioning regimen, resulting in tissue damage, systemic inflammation and elevated metabolic demands for amino acids to regenerate damaged tissues, reconstitute hematopoietic cells, and establish antioxidant defenses. Few studies have addressed the role of plasma amino acid (PAA) levels during transplantation, and it remains unknown if amino acid deficiency can aggravate treatment-related morbidity. We determined plasma levels of the 23 human amino acids in 80 HSCT patients (age 1.1-55.4 years) before conditioning and on day +7 and +21 post-transplant along with C-reactive protein (CRP) and Interleukin 6 (IL-6) levels on day +7. Significant changes were observed in plasma concentrations of several human amino acids during HSCT. On day +7, several amino acids were inversely correlated with both CRP and IL-6, including glutamic acid, serine, alanine, glutamine, arginine, cysteine, glycine, histidine, lysine, tryptophan, threonine, taurine, proline, and methionine (r between -0.22 and -0.66, all p<0.05). Patients developing sinusoidal obstruction syndrome (SOS) had significantly lower total PAA levels compared to patients without SOS (2013 ng/l (1709-2318) vs 2706 ng/l (2261-3150), p=0.006) along with lower individual levels of glutamic acid, serine, arginine, glycine, lysine, valine, tryptophan, threonine, and proline (all p<0.05) on day +7. Patients with severe acute graft-versus-host disease had lower total PAA level (1922 ng/l (1738-2106) vs 2649 ng/l (2244-3055), p=0.014) and decreased levels of serine, glutamine, cysteine, glycine, lysine and threonine on day +7 (all p<0.05). These results indicate a relationship between low concentrations of certain amino acids and risk of treatment-related complications.

KW - The Faculty of Science

KW - Hematopoietic stem cell transplantation

KW - Amino acids

KW - Systemic inflammation

KW - Sinusoidal obstruction syndrome

KW - Acute graft-versus-host disease

U2 - 10.1016/j.bbmt.2019.03.018

DO - 10.1016/j.bbmt.2019.03.018

M3 - Journal article

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

SN - 1083-8791

ER -

ID: 215506960