Probiotics for respiratory tract infections in children attending day care centers − a systematic review

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Standard

Probiotics for respiratory tract infections in children attending day care centers − a systematic review. / Laursen, Rikke Pilmann; Hojsak, Iva.

I: European Journal of Pediatrics, Bind 177, Nr. 7, 2018, s. 979-994.

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Harvard

Laursen, RP & Hojsak, I 2018, 'Probiotics for respiratory tract infections in children attending day care centers − a systematic review', European Journal of Pediatrics, bind 177, nr. 7, s. 979-994. https://doi.org/10.1007/s00431-018-3167-1

APA

Laursen, R. P., & Hojsak, I. (2018). Probiotics for respiratory tract infections in children attending day care centers − a systematic review. European Journal of Pediatrics, 177(7), 979-994. https://doi.org/10.1007/s00431-018-3167-1

Vancouver

Laursen RP, Hojsak I. Probiotics for respiratory tract infections in children attending day care centers − a systematic review. European Journal of Pediatrics. 2018;177(7):979-994. https://doi.org/10.1007/s00431-018-3167-1

Author

Laursen, Rikke Pilmann ; Hojsak, Iva. / Probiotics for respiratory tract infections in children attending day care centers − a systematic review. I: European Journal of Pediatrics. 2018 ; Bind 177, Nr. 7. s. 979-994.

Bibtex

@article{5f75668ac49643f0b990ef5aaac2763c,
title = "Probiotics for respiratory tract infections in children attending day care centers − a systematic review",
abstract = "Probiotics have been suggested to have a preventive effect on respiratory tract infections (RTIs), but limited evidence exist on strain-specific effects. The main aim of this systematic review and meta-analysis was to evaluate strain-specific probiotic effects on RTIs in children attending day care. We included 15 RCTs with 5121 children in day care settings (aged 3 months to 7 years), but due to high diversity in reported outcomes, different number of RCTs were available for evaluated outcomes. Twelve RCTs (n = 4527) reported results which could be compared in at least one outcome of the meta-analysis. Compared to placebo, Lactobacillus rhamnosus GG (LGG) significantly reduced duration of RTIs (three RCTs, n = 1295, mean difference − 0.78 days, 95{\%} confidence interval (CI) − 1.46; − 0.09), whereas no effect was found on other evaluated outcomes. Based on the results from two studies (n = 343), Bifidobacterium animalis subsp. lactis BB-12 showed no effect on duration of RTIs or on absence from day care. Meta-analyses on other strains or their combination were not possible due to limited data and different outcome measures. Conclusion: LGG is modestly effective in decreasing the duration of RTIs. More RCTs investigating specific probiotic strains or their combinations in prevention of RTIs are needed. (Table presented)",
keywords = "Acute otitis media, Children, Meta-analysis, RCT, Respiratory infections",
author = "Laursen, {Rikke Pilmann} and Iva Hojsak",
note = "CURIS 2018 NEXS 202",
year = "2018",
doi = "10.1007/s00431-018-3167-1",
language = "English",
volume = "177",
pages = "979--994",
journal = "European Journal of Pediatrics",
issn = "0340-6199",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Probiotics for respiratory tract infections in children attending day care centers − a systematic review

AU - Laursen, Rikke Pilmann

AU - Hojsak, Iva

N1 - CURIS 2018 NEXS 202

PY - 2018

Y1 - 2018

N2 - Probiotics have been suggested to have a preventive effect on respiratory tract infections (RTIs), but limited evidence exist on strain-specific effects. The main aim of this systematic review and meta-analysis was to evaluate strain-specific probiotic effects on RTIs in children attending day care. We included 15 RCTs with 5121 children in day care settings (aged 3 months to 7 years), but due to high diversity in reported outcomes, different number of RCTs were available for evaluated outcomes. Twelve RCTs (n = 4527) reported results which could be compared in at least one outcome of the meta-analysis. Compared to placebo, Lactobacillus rhamnosus GG (LGG) significantly reduced duration of RTIs (three RCTs, n = 1295, mean difference − 0.78 days, 95% confidence interval (CI) − 1.46; − 0.09), whereas no effect was found on other evaluated outcomes. Based on the results from two studies (n = 343), Bifidobacterium animalis subsp. lactis BB-12 showed no effect on duration of RTIs or on absence from day care. Meta-analyses on other strains or their combination were not possible due to limited data and different outcome measures. Conclusion: LGG is modestly effective in decreasing the duration of RTIs. More RCTs investigating specific probiotic strains or their combinations in prevention of RTIs are needed. (Table presented)

AB - Probiotics have been suggested to have a preventive effect on respiratory tract infections (RTIs), but limited evidence exist on strain-specific effects. The main aim of this systematic review and meta-analysis was to evaluate strain-specific probiotic effects on RTIs in children attending day care. We included 15 RCTs with 5121 children in day care settings (aged 3 months to 7 years), but due to high diversity in reported outcomes, different number of RCTs were available for evaluated outcomes. Twelve RCTs (n = 4527) reported results which could be compared in at least one outcome of the meta-analysis. Compared to placebo, Lactobacillus rhamnosus GG (LGG) significantly reduced duration of RTIs (three RCTs, n = 1295, mean difference − 0.78 days, 95% confidence interval (CI) − 1.46; − 0.09), whereas no effect was found on other evaluated outcomes. Based on the results from two studies (n = 343), Bifidobacterium animalis subsp. lactis BB-12 showed no effect on duration of RTIs or on absence from day care. Meta-analyses on other strains or their combination were not possible due to limited data and different outcome measures. Conclusion: LGG is modestly effective in decreasing the duration of RTIs. More RCTs investigating specific probiotic strains or their combinations in prevention of RTIs are needed. (Table presented)

KW - Acute otitis media

KW - Children

KW - Meta-analysis

KW - RCT

KW - Respiratory infections

U2 - 10.1007/s00431-018-3167-1

DO - 10.1007/s00431-018-3167-1

M3 - Review

C2 - 29752587

AN - SCOPUS:85046820522

VL - 177

SP - 979

EP - 994

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

IS - 7

ER -

ID: 197768616