Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures

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Standard

Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures. / Nielsen, Mette Søndergaard; Christensen, Bodil Just; Schmidt, Julie Berg; Tækker, Louise; Holm, Lotte; Lunn, Susanne; Ritz, Christian; Albrechtsen, Nicolai Jacob Wewer; Holst, Jens Juul; Schnurr, Theresia Maria; Hansen, Torben; le Roux, Carel W; Lund, Thomas Bøker; Floyd, Andrea Karen; Sjödin, Anders Mikael.

I: International Journal of Obesity, 23.04.2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Nielsen, MS, Christensen, BJ, Schmidt, JB, Tækker, L, Holm, L, Lunn, S, Ritz, C, Albrechtsen, NJW, Holst, JJ, Schnurr, TM, Hansen, T, le Roux, CW, Lund, TB, Floyd, AK & Sjödin, AM 2020, 'Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures', International Journal of Obesity. https://doi.org/10.1038/s41366-020-0576-9

APA

Nielsen, M. S., Christensen, B. J., Schmidt, J. B., Tækker, L., Holm, L., Lunn, S., ... Sjödin, A. M. (2020). Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures. International Journal of Obesity. https://doi.org/10.1038/s41366-020-0576-9

Vancouver

Nielsen MS, Christensen BJ, Schmidt JB, Tækker L, Holm L, Lunn S o.a. Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures. International Journal of Obesity. 2020 apr 23. https://doi.org/10.1038/s41366-020-0576-9

Author

Nielsen, Mette Søndergaard ; Christensen, Bodil Just ; Schmidt, Julie Berg ; Tækker, Louise ; Holm, Lotte ; Lunn, Susanne ; Ritz, Christian ; Albrechtsen, Nicolai Jacob Wewer ; Holst, Jens Juul ; Schnurr, Theresia Maria ; Hansen, Torben ; le Roux, Carel W ; Lund, Thomas Bøker ; Floyd, Andrea Karen ; Sjödin, Anders Mikael. / Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures. I: International Journal of Obesity. 2020.

Bibtex

@article{dd037b27da6e460d900714c810d15b44,
title = "Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures",
abstract = "Background: Bariatric surgery leads to a substantial weight loss (WL), however, a subset of patients undergoing surgery fails to achieve adequate WL. The reason for the individual variation in WL remains unexplained. Using an exploratory cross-disciplinary approach, we aimed to identify preoperative and early postoperative factors explaining the variation in WL after bariatric surgery.Methods: Sixty-one subjects were recruited. Eighteen subjects did not receive surgery and three subjects dropped out, leaving a total sample of 40 subjects. Physiological, social, and psychological data were collected before and 6 months after surgery. All variables were analyzed in combination using a least absolute shrinkage and selection operator (LASSO) regression to explain the variation in WL 18 months after Roux-en-Y gastric bypass (n = 30) and sleeve gastrectomy (n = 10).Results: Mean WL was 31{\%} (range: 10-52{\%}). The following preoperative factors predicted 59{\%} of the variation in WL: type of surgery (14{\%}), diabetes status (12{\%}), economic resources (9{\%}), sex (7{\%}), binge eating disorder (7{\%}), degree of depression (5{\%}), household type (3{\%}), and physical activity (1{\%}). Including information on early responses after surgery increased the ability to predict WL to 78{\%} and was explained by early WL (47{\%}), changes in energy density of food consumed from a buffet meal (9{\%}), changes in glicentin (5{\%}), degree of depression (5{\%}), sex (5{\%}), type of surgery (2{\%}), economic resources (2{\%}), and changes in drive for thinness (1{\%}).Conclusions: Using a cross-disciplinary approach, a substantial part of the individual variation in WL was explained by a combination of basic patient characteristics, psychological profile, and social conditions as well as physiological, psychological and behavioral responses to surgery. These results suggest that patient characteristics collected in a cross-disciplinary approach may help determine predictors for less successful WL after bariatric surgery. If verified in larger cohorts this may form the basis for individualized postoperative support to optimize WL outcome.",
author = "Nielsen, {Mette S{\o}ndergaard} and Christensen, {Bodil Just} and Schmidt, {Julie Berg} and Louise T{\ae}kker and Lotte Holm and Susanne Lunn and Christian Ritz and Albrechtsen, {Nicolai Jacob Wewer} and Holst, {Jens Juul} and Schnurr, {Theresia Maria} and Torben Hansen and {le Roux}, {Carel W} and Lund, {Thomas B{\o}ker} and Floyd, {Andrea Karen} and Sj{\"o}din, {Anders Mikael}",
note = "CURIS 2020 NEXS 128",
year = "2020",
month = "4",
day = "23",
doi = "10.1038/s41366-020-0576-9",
language = "English",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures

AU - Nielsen, Mette Søndergaard

AU - Christensen, Bodil Just

AU - Schmidt, Julie Berg

AU - Tækker, Louise

AU - Holm, Lotte

AU - Lunn, Susanne

AU - Ritz, Christian

AU - Albrechtsen, Nicolai Jacob Wewer

AU - Holst, Jens Juul

AU - Schnurr, Theresia Maria

AU - Hansen, Torben

AU - le Roux, Carel W

AU - Lund, Thomas Bøker

AU - Floyd, Andrea Karen

AU - Sjödin, Anders Mikael

N1 - CURIS 2020 NEXS 128

PY - 2020/4/23

Y1 - 2020/4/23

N2 - Background: Bariatric surgery leads to a substantial weight loss (WL), however, a subset of patients undergoing surgery fails to achieve adequate WL. The reason for the individual variation in WL remains unexplained. Using an exploratory cross-disciplinary approach, we aimed to identify preoperative and early postoperative factors explaining the variation in WL after bariatric surgery.Methods: Sixty-one subjects were recruited. Eighteen subjects did not receive surgery and three subjects dropped out, leaving a total sample of 40 subjects. Physiological, social, and psychological data were collected before and 6 months after surgery. All variables were analyzed in combination using a least absolute shrinkage and selection operator (LASSO) regression to explain the variation in WL 18 months after Roux-en-Y gastric bypass (n = 30) and sleeve gastrectomy (n = 10).Results: Mean WL was 31% (range: 10-52%). The following preoperative factors predicted 59% of the variation in WL: type of surgery (14%), diabetes status (12%), economic resources (9%), sex (7%), binge eating disorder (7%), degree of depression (5%), household type (3%), and physical activity (1%). Including information on early responses after surgery increased the ability to predict WL to 78% and was explained by early WL (47%), changes in energy density of food consumed from a buffet meal (9%), changes in glicentin (5%), degree of depression (5%), sex (5%), type of surgery (2%), economic resources (2%), and changes in drive for thinness (1%).Conclusions: Using a cross-disciplinary approach, a substantial part of the individual variation in WL was explained by a combination of basic patient characteristics, psychological profile, and social conditions as well as physiological, psychological and behavioral responses to surgery. These results suggest that patient characteristics collected in a cross-disciplinary approach may help determine predictors for less successful WL after bariatric surgery. If verified in larger cohorts this may form the basis for individualized postoperative support to optimize WL outcome.

AB - Background: Bariatric surgery leads to a substantial weight loss (WL), however, a subset of patients undergoing surgery fails to achieve adequate WL. The reason for the individual variation in WL remains unexplained. Using an exploratory cross-disciplinary approach, we aimed to identify preoperative and early postoperative factors explaining the variation in WL after bariatric surgery.Methods: Sixty-one subjects were recruited. Eighteen subjects did not receive surgery and three subjects dropped out, leaving a total sample of 40 subjects. Physiological, social, and psychological data were collected before and 6 months after surgery. All variables were analyzed in combination using a least absolute shrinkage and selection operator (LASSO) regression to explain the variation in WL 18 months after Roux-en-Y gastric bypass (n = 30) and sleeve gastrectomy (n = 10).Results: Mean WL was 31% (range: 10-52%). The following preoperative factors predicted 59% of the variation in WL: type of surgery (14%), diabetes status (12%), economic resources (9%), sex (7%), binge eating disorder (7%), degree of depression (5%), household type (3%), and physical activity (1%). Including information on early responses after surgery increased the ability to predict WL to 78% and was explained by early WL (47%), changes in energy density of food consumed from a buffet meal (9%), changes in glicentin (5%), degree of depression (5%), sex (5%), type of surgery (2%), economic resources (2%), and changes in drive for thinness (1%).Conclusions: Using a cross-disciplinary approach, a substantial part of the individual variation in WL was explained by a combination of basic patient characteristics, psychological profile, and social conditions as well as physiological, psychological and behavioral responses to surgery. These results suggest that patient characteristics collected in a cross-disciplinary approach may help determine predictors for less successful WL after bariatric surgery. If verified in larger cohorts this may form the basis for individualized postoperative support to optimize WL outcome.

U2 - 10.1038/s41366-020-0576-9

DO - 10.1038/s41366-020-0576-9

M3 - Journal article

C2 - 32327722

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -

ID: 240794827