Predictors of mortality among hospitalized children with severe acute malnutrition: a prospective study from Uganda

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Nicolette Nabukeera-Barungi, Benedikte Grenov, Betty Lanyero, Hanifa Namusoke, Ezekiel Mupere, Vibeke Brix Christensen, Kim F. Michaelsen, Christian Mølgaard, Maren Johanne Heilskov Rytter, Henrik Friis

Background: We determined the predictors of mortality among children admitted with severe acute malnutrition (SAM).

Methods: This was a prospective study nested in a randomized trial among 6-59-month-old children admitted with SAM. Socio-demographic and medical history data were collected using questionnaires and clinical examination, anthropometry and laboratory tests were performed. They were monitored daily until discharge or death during hospitalization while receiving care according to national guidelines. Predictors of death were assessed using Cox regression.

Results: Of 400 children, 9.8% (n = 39) died during hospitalization. Predictors of mortality included diarrhoea at admission [hazard ratio [HR] 2.19, 95% confidence interval (CI): 1.06; 4.51], lack of appetite [HR 4.50, 95% CI: 1.76; 11.50], suspected sepsis [HR 2.23, 95% CI: 1.18; 4.24] and skin ulcers [HR 4.23, 95% CI: 1.26; 4.17]. Chest indrawing [HR 5.0, 95% CI: 1.53; 16.3], oxygen saturation below 94% [HR 3.92, 95% CI: 1.42; 10.83] and confirmed HIV infection [HR 3.62, 95% CI: 1.69; 7.77] also predicted higher mortality.

Conclusion: Infections were major contributors to mortality. This underscores the need for improved prevention and management of these infections among children with severe malnutrition.

OriginalsprogEngelsk
TidsskriftPediatric Research
Vol/bind84
Sider (fra-til)92-98
Antal sider7
ISSN0031-3998
DOI
StatusUdgivet - 2018

Bibliografisk note

CURIS 2018 NEXS 181

ID: 197431385