Measuring growth and medium- and longer-term outcomes in malnourished children

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Victor O Owino, Alexia J Murphy-Alford, Marko Kerac, Paluku Bahwere, Henrik Friis, James A Berkley, Alan A Jackson

Severe and moderate acute malnutrition are among the leading causes of mortality among children in low- and middle-income countries. There is strong evidence that growth assessed anthropometrically from conception to 2 years of age marks later risk of ill-health. This is central to the concept of the developmental origins of adult disease and is presumed to be related to modification of developmental processes during critical "window(s)" of vulnerability. Interventions to treat acute malnutrition have resulted in dramatic increase in the number of affected children surviving. Ensuring that these children thrive to fulfil their full physical and cognitive potential is a new challenge. Integral to this challenge is the need to be able to measure how earlier insults relate to the ability to survive and thrive to productive adulthood. Despite its obvious value, routine anthropometry does not adequately indicate how earlier adverse exposures affect more refined aspects of growth. Anthropometry is inadequate for predicting how disruption of healthy growth might modulate risk of disease, or any subsequent interventions correct this risk. A clear characterisation of healthy child growth is needed for determining which component best predicts later outcomes. The extent to which postnatal acute malnutrition is a consequence of maternal factors acting pre-conception or in-utero and their relationship to postnatal health and long-term risk of non-communicable diseases is not clear. Body composition measurement has significant untapped potential allowing us to translate and better understand the relationship between early insults and interventions on early growth in the short-term and long-term health outcomes.

OriginalsprogEngelsk
Artikelnummere12790
TidsskriftMaternal and Child Nutrition
Vol/bind15
Udgave nummer3
Antal sider10
ISSN1740-8695
DOI
StatusUdgivet - 2019

Bibliografisk note

CURIS 2019 NEXS 079

ID: 212906075