Iron concentration in breast milk normalised within one week of a single high-dose infusion of iron isomaltoside in randomised controlled trial

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Charlotte Holm, Lars Lykke Thomsen, Astrid Nørgaard, Veronika Markova, Kim F. Michaelsen, Jens Langhoff-Roos

AIM: We compared the iron concentration in breast milk after a single high-dose of intravenous iron isomaltoside or daily oral iron for postpartum haemorrhage.

METHODS: In this randomised controlled trial, the women were allocated a single dose of intravenous 1,200mg iron isomaltoside or oral iron at a mean daily dose of 70.5mg. We included 65 women with sufficient breast milk three days after inclusion - 30 from the intravenous iron group and 35 from the oral iron group - and collected breast milk and maternal blood samples three days and one week after allocation.

RESULTS: The mean (± standard deviation) iron concentration in breast milk in the intravenous and oral groups were 0.72 ± 0.27 mg/L and 0.40 ± 0.18 mg/L at three days (p < 0.001) and 0.47 ± 0.17 mg/L and 0.44 ± 0.25 mg/L after one week (p=0.64). Baseline samples were not available that soon after birth.

CONCLUSION: A single high-dose of intravenous iron isomaltoside for postpartum haemorrhage led to a transient increase in the iron concentration in breast milk three days after treatment compared with oral iron. The difference disappeared one week after treatment and mean iron concentrations were within the normal range in all samples. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftActa Paediatrica
Vol/bind106
Udgave nummer2
Sider (fra-til)256-260
Antal sider5
ISSN0803-5253
DOI
StatusUdgivet - 2017

Bibliografisk note

CURIS 2017 NEXS 019

ID: 169376948