Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D. / Cashman, Kevin D; Kiely, Mairead E; Andersen, Rikke; Grønborg, Ida M; Madsen, Katja Howarth; Nissen, Janna; Tetens, Inge; Tripkovic, Laura; Lanham-New, Susan A; Toxqui, Laura; Vaquero, M Pilar; Trautvetter, Ulrike; Jahreis, Gerhard; Mistry, Vikram V; Specker, Bonny L; Hower, Jürgen; Knoll, Anette; Wagner, Dennis; Vieth, Reinhold; Öhlund, Inger; Karlsland Åkeson, Pia; Brett, Neil R; Weiler, Hope A; Ritz, Christian.

I: European Journal of Nutrition, 15.06.2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Cashman, KD, Kiely, ME, Andersen, R, Grønborg, IM, Madsen, KH, Nissen, J, Tetens, I, Tripkovic, L, Lanham-New, SA, Toxqui, L, Vaquero, MP, Trautvetter, U, Jahreis, G, Mistry, VV, Specker, BL, Hower, J, Knoll, A, Wagner, D, Vieth, R, Öhlund, I, Karlsland Åkeson, P, Brett, NR, Weiler, HA & Ritz, C 2020, 'Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D', European Journal of Nutrition. https://doi.org/10.1007/s00394-020-02298-x

APA

Cashman, K. D., Kiely, M. E., Andersen, R., Grønborg, I. M., Madsen, K. H., Nissen, J., ... Ritz, C. (2020). Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D. European Journal of Nutrition. https://doi.org/10.1007/s00394-020-02298-x

Vancouver

Cashman KD, Kiely ME, Andersen R, Grønborg IM, Madsen KH, Nissen J o.a. Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D. European Journal of Nutrition. 2020 jun 15. https://doi.org/10.1007/s00394-020-02298-x

Author

Cashman, Kevin D ; Kiely, Mairead E ; Andersen, Rikke ; Grønborg, Ida M ; Madsen, Katja Howarth ; Nissen, Janna ; Tetens, Inge ; Tripkovic, Laura ; Lanham-New, Susan A ; Toxqui, Laura ; Vaquero, M Pilar ; Trautvetter, Ulrike ; Jahreis, Gerhard ; Mistry, Vikram V ; Specker, Bonny L ; Hower, Jürgen ; Knoll, Anette ; Wagner, Dennis ; Vieth, Reinhold ; Öhlund, Inger ; Karlsland Åkeson, Pia ; Brett, Neil R ; Weiler, Hope A ; Ritz, Christian. / Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D. I: European Journal of Nutrition. 2020.

Bibtex

@article{9fc4e8bf634449b9a643f3ca0e74fce7,
title = "Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D",
abstract = "Context and purpose: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D.Methods: IPD analysis using data from 1429 participants (ages 2-89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models.Results: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5{\%} of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90{\%}, 95{\%} and 97.5{\%} of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI).Conclusions: IPD-derived vitamin D intakes required to maintain 90{\%}, 95{\%} and 97.5{\%} of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.",
keywords = "Faculty of Science, Vitamin D recommendations, Dietary reference values, Recommended dietary allowance, Individual Participant Data-level meta-regression analyses, Vitamin D-fortified foods",
author = "Cashman, {Kevin D} and Kiely, {Mairead E} and Rikke Andersen and Gr{\o}nborg, {Ida M} and Madsen, {Katja Howarth} and Janna Nissen and Inge Tetens and Laura Tripkovic and Lanham-New, {Susan A} and Laura Toxqui and Vaquero, {M Pilar} and Ulrike Trautvetter and Gerhard Jahreis and Mistry, {Vikram V} and Specker, {Bonny L} and J{\"u}rgen Hower and Anette Knoll and Dennis Wagner and Reinhold Vieth and Inger {\"O}hlund and {Karlsland {\AA}keson}, Pia and Brett, {Neil R} and Weiler, {Hope A} and Christian Ritz",
note = "CURIS 2020 NEXS 197",
year = "2020",
month = "6",
day = "15",
doi = "10.1007/s00394-020-02298-x",
language = "English",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "Springer Medizin",

}

RIS

TY - JOUR

T1 - Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D

AU - Cashman, Kevin D

AU - Kiely, Mairead E

AU - Andersen, Rikke

AU - Grønborg, Ida M

AU - Madsen, Katja Howarth

AU - Nissen, Janna

AU - Tetens, Inge

AU - Tripkovic, Laura

AU - Lanham-New, Susan A

AU - Toxqui, Laura

AU - Vaquero, M Pilar

AU - Trautvetter, Ulrike

AU - Jahreis, Gerhard

AU - Mistry, Vikram V

AU - Specker, Bonny L

AU - Hower, Jürgen

AU - Knoll, Anette

AU - Wagner, Dennis

AU - Vieth, Reinhold

AU - Öhlund, Inger

AU - Karlsland Åkeson, Pia

AU - Brett, Neil R

AU - Weiler, Hope A

AU - Ritz, Christian

N1 - CURIS 2020 NEXS 197

PY - 2020/6/15

Y1 - 2020/6/15

N2 - Context and purpose: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D.Methods: IPD analysis using data from 1429 participants (ages 2-89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models.Results: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI).Conclusions: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.

AB - Context and purpose: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D.Methods: IPD analysis using data from 1429 participants (ages 2-89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models.Results: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI).Conclusions: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.

KW - Faculty of Science

KW - Vitamin D recommendations

KW - Dietary reference values

KW - Recommended dietary allowance

KW - Individual Participant Data-level meta-regression analyses

KW - Vitamin D-fortified foods

U2 - 10.1007/s00394-020-02298-x

DO - 10.1007/s00394-020-02298-x

M3 - Journal article

C2 - 32556447

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

ER -

ID: 243340836