High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children

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High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children. / Whitfield, Kyly C; Smith, Geoffry; Chamnan, Chhoun; Karakochuk, Crystal D; Sophonneary, Prak; Khov, Kuong; Dijkhuizen, Marjoleine Amma; Hong, Rathavuth; Berger, Jacques; Green, Tim J; Wieringa, Frank Tammo.

I: P L o S Neglected Tropical Diseases (Online), Bind 11, Nr. 9, e0005814, 2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Whitfield, KC, Smith, G, Chamnan, C, Karakochuk, CD, Sophonneary, P, Khov, K, Dijkhuizen, MA, Hong, R, Berger, J, Green, TJ & Wieringa, FT 2017, 'High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children', P L o S Neglected Tropical Diseases (Online), bind 11, nr. 9, e0005814. https://doi.org/10.1371/journal.pntd.0005814

APA

Whitfield, K. C., Smith, G., Chamnan, C., Karakochuk, C. D., Sophonneary, P., Khov, K., ... Wieringa, F. T. (2017). High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children. P L o S Neglected Tropical Diseases (Online), 11(9), [e0005814]. https://doi.org/10.1371/journal.pntd.0005814

Vancouver

Whitfield KC, Smith G, Chamnan C, Karakochuk CD, Sophonneary P, Khov K o.a. High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children. P L o S Neglected Tropical Diseases (Online). 2017;11(9). e0005814. https://doi.org/10.1371/journal.pntd.0005814

Author

Whitfield, Kyly C ; Smith, Geoffry ; Chamnan, Chhoun ; Karakochuk, Crystal D ; Sophonneary, Prak ; Khov, Kuong ; Dijkhuizen, Marjoleine Amma ; Hong, Rathavuth ; Berger, Jacques ; Green, Tim J ; Wieringa, Frank Tammo. / High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children. I: P L o S Neglected Tropical Diseases (Online). 2017 ; Bind 11, Nr. 9.

Bibtex

@article{2c7ba08583cb4da7a126b2dbc1e6deed,
title = "High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children",
abstract = "BACKGROUND: Thiamine deficiency is thought to be an issue in Cambodia and throughout Southeast Asia due to frequent clinical reports of infantile beriberi. However the extent of this public health issue is currently unknown due to a lack of population-representative data. Therefore we assessed the thiamine status (measured as erythrocyte thiamine diphosphate concentrations; eThDP) among a representative sample of Cambodian women of childbearing age (15-49 y) and their young children (6-69 mo).METHODOLOGY/PRINCIPLE FINDINGS: Samples for this cross-sectional analysis were collected as part of a national micronutrient survey linked to the Cambodian Demographic and Health Survey (CDHS) 2014. One-sixth of households taking part in the CDHS were randomly selected and re-visited for additional blood sampling for eThDP analysis (719 women and 761 children). Thiamine status was assessed using different cut-offs from literature. Women were mean (SD) 30 (6) y, and children (46{\%} girls) were 41 (17) mo. Women had lower mean (95{\%} CI) eThDP of 150 nmol/L (146-153) compared to children, 174 nmol/L (171-179; P < 0.001). Using the most conservative cut-off of eThDP < 120 nmol/L, 27{\%} of mothers and 15{\%} of children were thiamine deficient, however prevalence rates of deficiency were as high as 78{\%} for mothers and 58{\%} for children using a cut-off of < 180 nmol/L. Thiamine deficiency was especially prevalent among infants aged 6-12 mo: 38{\%} were deficient using the most conservative cut-off (< 120 nmol/L).CONCLUSIONS/SIGNIFICANCE: There is a lack of consensus on thiamine status cut-offs; more research is required to set clinically meaningful cut-offs. Despite this, there is strong evidence of suboptimal thiamine status among Cambodian mothers and their children, with infants <12 mo at the highest risk. Based on eThDP from this nationally-representative sample, immediate action is required to address thiamine deficiency in Cambodia, and likely throughout Southeast Asia.",
keywords = "Adolescent, Adult, Cambodia, Child, Child, Preschool, Cross-Sectional Studies, Erythrocytes, Female, Humans, Infant, Male, Middle Aged, Prevalence, Random Allocation, Thiamine, Thiamine Deficiency, Young Adult, Journal Article",
author = "Whitfield, {Kyly C} and Geoffry Smith and Chhoun Chamnan and Karakochuk, {Crystal D} and Prak Sophonneary and Kuong Khov and Dijkhuizen, {Marjoleine Amma} and Rathavuth Hong and Jacques Berger and Green, {Tim J} and Wieringa, {Frank Tammo}",
note = "CURIS 2017 NEXS 360",
year = "2017",
doi = "10.1371/journal.pntd.0005814",
language = "English",
volume = "11",
journal = "P L o S Neglected Tropical Diseases (Online)",
issn = "1935-2735",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children

AU - Whitfield, Kyly C

AU - Smith, Geoffry

AU - Chamnan, Chhoun

AU - Karakochuk, Crystal D

AU - Sophonneary, Prak

AU - Khov, Kuong

AU - Dijkhuizen, Marjoleine Amma

AU - Hong, Rathavuth

AU - Berger, Jacques

AU - Green, Tim J

AU - Wieringa, Frank Tammo

N1 - CURIS 2017 NEXS 360

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Thiamine deficiency is thought to be an issue in Cambodia and throughout Southeast Asia due to frequent clinical reports of infantile beriberi. However the extent of this public health issue is currently unknown due to a lack of population-representative data. Therefore we assessed the thiamine status (measured as erythrocyte thiamine diphosphate concentrations; eThDP) among a representative sample of Cambodian women of childbearing age (15-49 y) and their young children (6-69 mo).METHODOLOGY/PRINCIPLE FINDINGS: Samples for this cross-sectional analysis were collected as part of a national micronutrient survey linked to the Cambodian Demographic and Health Survey (CDHS) 2014. One-sixth of households taking part in the CDHS were randomly selected and re-visited for additional blood sampling for eThDP analysis (719 women and 761 children). Thiamine status was assessed using different cut-offs from literature. Women were mean (SD) 30 (6) y, and children (46% girls) were 41 (17) mo. Women had lower mean (95% CI) eThDP of 150 nmol/L (146-153) compared to children, 174 nmol/L (171-179; P < 0.001). Using the most conservative cut-off of eThDP < 120 nmol/L, 27% of mothers and 15% of children were thiamine deficient, however prevalence rates of deficiency were as high as 78% for mothers and 58% for children using a cut-off of < 180 nmol/L. Thiamine deficiency was especially prevalent among infants aged 6-12 mo: 38% were deficient using the most conservative cut-off (< 120 nmol/L).CONCLUSIONS/SIGNIFICANCE: There is a lack of consensus on thiamine status cut-offs; more research is required to set clinically meaningful cut-offs. Despite this, there is strong evidence of suboptimal thiamine status among Cambodian mothers and their children, with infants <12 mo at the highest risk. Based on eThDP from this nationally-representative sample, immediate action is required to address thiamine deficiency in Cambodia, and likely throughout Southeast Asia.

AB - BACKGROUND: Thiamine deficiency is thought to be an issue in Cambodia and throughout Southeast Asia due to frequent clinical reports of infantile beriberi. However the extent of this public health issue is currently unknown due to a lack of population-representative data. Therefore we assessed the thiamine status (measured as erythrocyte thiamine diphosphate concentrations; eThDP) among a representative sample of Cambodian women of childbearing age (15-49 y) and their young children (6-69 mo).METHODOLOGY/PRINCIPLE FINDINGS: Samples for this cross-sectional analysis were collected as part of a national micronutrient survey linked to the Cambodian Demographic and Health Survey (CDHS) 2014. One-sixth of households taking part in the CDHS were randomly selected and re-visited for additional blood sampling for eThDP analysis (719 women and 761 children). Thiamine status was assessed using different cut-offs from literature. Women were mean (SD) 30 (6) y, and children (46% girls) were 41 (17) mo. Women had lower mean (95% CI) eThDP of 150 nmol/L (146-153) compared to children, 174 nmol/L (171-179; P < 0.001). Using the most conservative cut-off of eThDP < 120 nmol/L, 27% of mothers and 15% of children were thiamine deficient, however prevalence rates of deficiency were as high as 78% for mothers and 58% for children using a cut-off of < 180 nmol/L. Thiamine deficiency was especially prevalent among infants aged 6-12 mo: 38% were deficient using the most conservative cut-off (< 120 nmol/L).CONCLUSIONS/SIGNIFICANCE: There is a lack of consensus on thiamine status cut-offs; more research is required to set clinically meaningful cut-offs. Despite this, there is strong evidence of suboptimal thiamine status among Cambodian mothers and their children, with infants <12 mo at the highest risk. Based on eThDP from this nationally-representative sample, immediate action is required to address thiamine deficiency in Cambodia, and likely throughout Southeast Asia.

KW - Adolescent

KW - Adult

KW - Cambodia

KW - Child

KW - Child, Preschool

KW - Cross-Sectional Studies

KW - Erythrocytes

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Random Allocation

KW - Thiamine

KW - Thiamine Deficiency

KW - Young Adult

KW - Journal Article

U2 - 10.1371/journal.pntd.0005814

DO - 10.1371/journal.pntd.0005814

M3 - Journal article

C2 - 28873391

VL - 11

JO - P L o S Neglected Tropical Diseases (Online)

JF - P L o S Neglected Tropical Diseases (Online)

SN - 1935-2735

IS - 9

M1 - e0005814

ER -

ID: 187005411