High bone mineral apparent density in children with X-linked hypophosphatemia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Signe Beck-Nielsen, K Brixen, J Gram, Christian Mølgaard

Bone mineral apparent density (BMAD) in children with X-linked hypophosphatemia (XLH) was evaluated, as they are unlikely to have extra-skeletal ossifications contributing to the elevated bone mineral density of the spine in adult patients. Children with XLH also had significantly higher BMAD of the spine compared to femoral neck. INTRODUCTION: BMAD obtained by dual-energy X-ray absorptiometry scans in children with XLH was evaluated, as they are unlikely to have the extra-skeletal ossifications contributing to the elevated bone mineral density of the spine in adult patients. METHODS: A total of 15 children with biochemically and genetically verified XLH were recruited. Anthropometric measurements were performed, and to correct for the short stature (small bones), the BMAD of the spine and the femoral neck was evaluated. RESULTS: Z-scores of BMAD of the spine (mean (95 % CI); 2.0 (1.3-2.7); p 
OriginalsprogEngelsk
TidsskriftOsteoporosis International
Vol/bind24
Udgave nummer8
Sider (fra-til)2215-2221
Antal sider7
ISSN0937-941X
DOI
StatusUdgivet - 2013

Bibliografisk note

CURIS 2013 NEXS 146

ID: 46982280