Glucose tolerance in obese pregnant women determines newborn fat mass

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Emma Malchau Carlsen, Kristina Martha Renault, Kirsten Nørgaard, Lisbeth Nilas, Jens-Erik B. Jensen, Mette Friberg Hitz, Kim F. Michaelsen, Dina Cortes, Ole Pryds

INTRODUCTION: Offspring of obese women have both short- and long-term increased morbidities. We investigated the relationship between maternal 2-h plasma glucose level determined by oral glucose tolerance test, degree of obesity, gestational weight gain and total fat, abdominal fat, and fat-free masses in the offspring of obese mothers.

MATERIAL AND METHODS: Obese mother-newborn dyads were recruited and 2-h plasma glucose levels were assessed during gestational weeks 27-30; neonatal body composition was measured by dual-energy X-ray absorptiometry scanning (DXA) within 48 hours of birth.

RESULTS: Among 264 term, healthy, and singleton infants eligible for inclusion, 248 were included. Of these 205 (83%) obese mother-newborn-dyads had a DXA scan and 2-h plasma glucose measurements. Linear regression analysis showed that birth weight z-scores correlated with 2-h plasma glucose levels (p = 0.002) after adjusting for gestational weight gain, maternal age, education, smoking, pre-pregnancy degree of obesity, parity, and birth length. Total (p = 0.012) and abdominal (p = 0.039) fat masses correlated with 2-h plasma glucose levels after adjusting for gestational weight gain, maternal age, education, smoking, pre-pregnancy degree of obesity, parity, gestational age, and newborn sex. There was no association between total (p = 0.88) and abdominal (p = 0.61) fat-free masses and 2-h plasma glucose.

CONCLUSION: At 27-30 weeks of gestation, 2-h plasma glucose levels are related to total and abdominal newborn fat masses, but not to fat-free mass. Interventions targeting maternal postprandial glucose levels may induce more appropriate birth weight, thereby reducing the risk of subsequent morbidity. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftActa Obstetricia et Gynecologica Scandinavica
Vol/bind95
Udgave nummer4
Sider (fra-til)429-435
Antal sider7
ISSN0001-6349
DOI
StatusUdgivet - 2016

Bibliografisk note

CURIS 2016 NEXS 037

ID: 152990441