Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents. / Viitasalo, Anna; Schnurr, Theresia Maria; Pitkänen, Niina; Hollensted, Mette; Nielsen, Tenna R H; Pahkala, Katja; Lintu, Niina; Lind, Mads Vendelbo; Atalay, Mustafa; Frithioff-Bøjsøe, Christine; Fonvig, Cilius Esmann; Grarup, Niels; Kähönen, Mika; Larnkjær, Anni; Pedersen, Oluf Borbye; Holm, Jens-Christian; Michaelsen, Kim F.; Lakka, Timo A; Lehtimäki, Terho; Raitakari, Olli; Hansen, Torben; Kilpeläinen, Tuomas Oskari.

I: International Journal of Obesity, 22.07.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Viitasalo, A, Schnurr, TM, Pitkänen, N, Hollensted, M, Nielsen, TRH, Pahkala, K, Lintu, N, Lind, MV, Atalay, M, Frithioff-Bøjsøe, C, Fonvig, CE, Grarup, N, Kähönen, M, Larnkjær, A, Pedersen, OB, Holm, J-C, Michaelsen, KF, Lakka, TA, Lehtimäki, T, Raitakari, O, Hansen, T & Kilpeläinen, TO 2019, 'Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents', International Journal of Obesity. https://doi.org/10.1038/s41366-019-0414-0

APA

Viitasalo, A., Schnurr, T. M., Pitkänen, N., Hollensted, M., Nielsen, T. R. H., Pahkala, K., ... Kilpeläinen, T. O. (2019). Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents. International Journal of Obesity. https://doi.org/10.1038/s41366-019-0414-0

Vancouver

Viitasalo A, Schnurr TM, Pitkänen N, Hollensted M, Nielsen TRH, Pahkala K o.a. Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents. International Journal of Obesity. 2019 jul 22. https://doi.org/10.1038/s41366-019-0414-0

Author

Viitasalo, Anna ; Schnurr, Theresia Maria ; Pitkänen, Niina ; Hollensted, Mette ; Nielsen, Tenna R H ; Pahkala, Katja ; Lintu, Niina ; Lind, Mads Vendelbo ; Atalay, Mustafa ; Frithioff-Bøjsøe, Christine ; Fonvig, Cilius Esmann ; Grarup, Niels ; Kähönen, Mika ; Larnkjær, Anni ; Pedersen, Oluf Borbye ; Holm, Jens-Christian ; Michaelsen, Kim F. ; Lakka, Timo A ; Lehtimäki, Terho ; Raitakari, Olli ; Hansen, Torben ; Kilpeläinen, Tuomas Oskari. / Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents. I: International Journal of Obesity. 2019.

Bibtex

@article{2910e1d709f143688828b96c0165b290,
title = "Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents",
abstract = "Background: Most obese children show cardiometabolic impairments, such as insulin resistance, dyslipidemia, and hypertension. Yet some obese children retain a normal cardiometabolic profile. The mechanisms underlying this variability remain largely unknown. We examined whether genetic loci associated with increased insulin sensitivity and relatively higher fat storage on the hip than on the waist in adults are associated with a normal cardiometabolic profile despite higher adiposity in children.Methods: We constructed a genetic score using variants previously linked to increased insulin sensitivity and/or decreased waist-hip ratio adjusted for body mass index (BMI), and examined the associations of this genetic score with adiposity and cardiometabolic impairments in a meta-analysis of six cohorts, including 7391 European children aged 3-18 years.Results: The genetic score was significantly associated with increased degree of obesity (higher BMI-SDS beta = 0.009 SD/allele, SE = 0.003, P = 0.003; higher body fat mass beta = 0.009, SE = 0.004, P = 0.031), yet improved body fat distribution (lower WHRadjBMI beta = -0.014 SD/allele, SE = 0.006, P = 0.016), and favorable concentrations of blood lipids (higher HDL cholesterol: beta = 0.010 SD/allele, SE = 0.003, P = 0.002; lower triglycerides: beta = -0.011 SD/allele, SE = 0.003, P = 0.001) adjusted for age, sex, and puberty. No differences were detected between prepubertal and pubertal/postpubertal children. The genetic score predicted a normal cardiometabolic profile, defined by the presence of normal glucose and lipid concentrations, among obese children (OR = 1.07 CI 95{\%} 1.01-1.13, P = 0.012, n = 536).Conclusions: Genetic predisposition to higher body fat yet lower cardiometabolic risk exerts its influence before puberty.",
author = "Anna Viitasalo and Schnurr, {Theresia Maria} and Niina Pitk{\"a}nen and Mette Hollensted and Nielsen, {Tenna R H} and Katja Pahkala and Niina Lintu and Lind, {Mads Vendelbo} and Mustafa Atalay and Christine Frithioff-B{\o}js{\o}e and Fonvig, {Cilius Esmann} and Niels Grarup and Mika K{\"a}h{\"o}nen and Anni Larnkj{\ae}r and Pedersen, {Oluf Borbye} and Jens-Christian Holm and Michaelsen, {Kim F.} and Lakka, {Timo A} and Terho Lehtim{\"a}ki and Olli Raitakari and Torben Hansen and Kilpel{\"a}inen, {Tuomas Oskari}",
note = "CURIS 2019 NEXS 228",
year = "2019",
month = "7",
day = "22",
doi = "10.1038/s41366-019-0414-0",
language = "English",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents

AU - Viitasalo, Anna

AU - Schnurr, Theresia Maria

AU - Pitkänen, Niina

AU - Hollensted, Mette

AU - Nielsen, Tenna R H

AU - Pahkala, Katja

AU - Lintu, Niina

AU - Lind, Mads Vendelbo

AU - Atalay, Mustafa

AU - Frithioff-Bøjsøe, Christine

AU - Fonvig, Cilius Esmann

AU - Grarup, Niels

AU - Kähönen, Mika

AU - Larnkjær, Anni

AU - Pedersen, Oluf Borbye

AU - Holm, Jens-Christian

AU - Michaelsen, Kim F.

AU - Lakka, Timo A

AU - Lehtimäki, Terho

AU - Raitakari, Olli

AU - Hansen, Torben

AU - Kilpeläinen, Tuomas Oskari

N1 - CURIS 2019 NEXS 228

PY - 2019/7/22

Y1 - 2019/7/22

N2 - Background: Most obese children show cardiometabolic impairments, such as insulin resistance, dyslipidemia, and hypertension. Yet some obese children retain a normal cardiometabolic profile. The mechanisms underlying this variability remain largely unknown. We examined whether genetic loci associated with increased insulin sensitivity and relatively higher fat storage on the hip than on the waist in adults are associated with a normal cardiometabolic profile despite higher adiposity in children.Methods: We constructed a genetic score using variants previously linked to increased insulin sensitivity and/or decreased waist-hip ratio adjusted for body mass index (BMI), and examined the associations of this genetic score with adiposity and cardiometabolic impairments in a meta-analysis of six cohorts, including 7391 European children aged 3-18 years.Results: The genetic score was significantly associated with increased degree of obesity (higher BMI-SDS beta = 0.009 SD/allele, SE = 0.003, P = 0.003; higher body fat mass beta = 0.009, SE = 0.004, P = 0.031), yet improved body fat distribution (lower WHRadjBMI beta = -0.014 SD/allele, SE = 0.006, P = 0.016), and favorable concentrations of blood lipids (higher HDL cholesterol: beta = 0.010 SD/allele, SE = 0.003, P = 0.002; lower triglycerides: beta = -0.011 SD/allele, SE = 0.003, P = 0.001) adjusted for age, sex, and puberty. No differences were detected between prepubertal and pubertal/postpubertal children. The genetic score predicted a normal cardiometabolic profile, defined by the presence of normal glucose and lipid concentrations, among obese children (OR = 1.07 CI 95% 1.01-1.13, P = 0.012, n = 536).Conclusions: Genetic predisposition to higher body fat yet lower cardiometabolic risk exerts its influence before puberty.

AB - Background: Most obese children show cardiometabolic impairments, such as insulin resistance, dyslipidemia, and hypertension. Yet some obese children retain a normal cardiometabolic profile. The mechanisms underlying this variability remain largely unknown. We examined whether genetic loci associated with increased insulin sensitivity and relatively higher fat storage on the hip than on the waist in adults are associated with a normal cardiometabolic profile despite higher adiposity in children.Methods: We constructed a genetic score using variants previously linked to increased insulin sensitivity and/or decreased waist-hip ratio adjusted for body mass index (BMI), and examined the associations of this genetic score with adiposity and cardiometabolic impairments in a meta-analysis of six cohorts, including 7391 European children aged 3-18 years.Results: The genetic score was significantly associated with increased degree of obesity (higher BMI-SDS beta = 0.009 SD/allele, SE = 0.003, P = 0.003; higher body fat mass beta = 0.009, SE = 0.004, P = 0.031), yet improved body fat distribution (lower WHRadjBMI beta = -0.014 SD/allele, SE = 0.006, P = 0.016), and favorable concentrations of blood lipids (higher HDL cholesterol: beta = 0.010 SD/allele, SE = 0.003, P = 0.002; lower triglycerides: beta = -0.011 SD/allele, SE = 0.003, P = 0.001) adjusted for age, sex, and puberty. No differences were detected between prepubertal and pubertal/postpubertal children. The genetic score predicted a normal cardiometabolic profile, defined by the presence of normal glucose and lipid concentrations, among obese children (OR = 1.07 CI 95% 1.01-1.13, P = 0.012, n = 536).Conclusions: Genetic predisposition to higher body fat yet lower cardiometabolic risk exerts its influence before puberty.

U2 - 10.1038/s41366-019-0414-0

DO - 10.1038/s41366-019-0414-0

M3 - Journal article

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -

ID: 224898619