Fish oil as a potential activator of brown and beige fat thermogenesis

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Jens Lund, Lesli Hingstrup Larsen, Lotte Lauritzen

Numerous studies have shown that feeding rodents n-3 polyunsaturated fatty acids attenuates adiposity. Moreover, meta-analyses of human dietary intervention studies indicate that fish oil (eicosapentaenoic and docosahexaenoic acid) supplementation might reduce waist circumference. A recent line of research suggests that browning of white adipose depots and activation of uncoupled respiration in brown fat contributes to these effects. This mini-review summarizes the observations in rodents, highlights several mechanisms that might explain these observations and discusses the translational potential. Given the available in vivo evidence and the ability of human adipocytes to aquire a beige phenotype in response to eicosapentaenoic acid incubation, future studies should test the hypothesis that fish oil activates thermogenic brown and beige adipose tissue in humans.

OriginalsprogEngelsk
TidsskriftAdipocytes
Vol/bind7
Udgave nummer2
Sider (fra-til)88-95
Antal sider8
ISSN1550-2082
DOI
StatusUdgivet - 2018

Bibliografisk note

CURIS 2018 NEXS 095

ID: 192515870