Efficacy of fish intake on vitamin D status: a meta-analysis of randomized controlled trials

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Ulrike Lehmann, Hanne Rosendahl Gjessing, Frank Hirche, Andreas Mueller-Belecke, Oddrun Anita Gudbrandsen, Per Magne Ueland, Gunnar Mellgren, Lotte Lauritzen, Helen Lindqvist, Anita Lill Hansen, Arja T Erkkilä, Gerda K Pot, Gabriele I Stangl, Jutta Dierkes

BACKGROUND: It is well known that fish is the major natural source of vitamin D in the diet; therefore, this meta-analysis investigated the influence of fish consumption in randomized controlled trials (RCTs) on serum 25-hydroxyvitamin D [25(OH)D] concentrations.

OBJECTIVE: A literature search was carried out in Medline, Embase, Web of Science, and the Cochrane Library (up to February 2014) for RCTs that investigated the effect of fish consumption on 25(OH)D concentrations in comparison to other dietary interventions.

RESULTS: Seven articles and 2 unpublished study data sets with 640 subjects and 14 study groups met the inclusion criteria and were included in this meta-analysis. Compared with controls, the consumption of fish increased 25(OH)D concentrations, on average, by 4.4 nmol/L (95% CI: 1.7, 7.1 nmol/L; P < 0.0001, I(2) = 25%; 9 studies).The type of the fish also played a key role: the consumption of fatty fish resulted in a mean difference of 6.8 nmol/L (95% CI: 3.7, 9.9 nmol/L; P < 0.0001, I(2) = 0%; 7 study groups), whereas for lean fish the mean difference was 1.9 nmol/L (95% CI: -2.3, 6.0 nmol/L; P < 0.38, I(2) = 37%; 7 study groups). Short-term studies (4-8 wk) showed a mean difference of 3.8 nmol/L (95% CI: 0.6, 6.9 nmol/L; P < 0.02, I(2) = 38%; 10 study groups), whereas in long-term studies (∼6 mo) the mean difference was 8.3 nmol/L (95% CI: 2.1, 14.5 nmol/L; P < 0.009, I(2) = 0%; 4 study groups).

CONCLUSION: As the major food source of vitamin D, fish consumption increases concentrations of 25(OH)D, although recommended fish intakes cannot optimize vitamin D status.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Clinical Nutrition
Vol/bind102
Udgave nummer4
Sider (fra-til)837-847
Antal sider11
ISSN0002-9165
DOI
StatusUdgivet - 2015

Bibliografisk note

CURIS 2015 NEXS 339

ID: 144413390