Effects on anthropometry and appetite of vitamins and minerals given in lipid nutritional supplements for malnourished HIV-infected adults referred for antiretroviral therapy: Results from the NUSTART randomised controlled trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt


  • Andrea M Rehman
  • Susannah Woodd
  • George PrayGod
  • Molly Chisenga
  • Joshua Siame
  • John R Koethe
  • Douglas C Heimburger
  • Paul Kelly
  • Friis, Henrik
  • Suzanne Filteau

BACKGROUND:: The evidence base for effects of nutritional interventions for malnourished HIV-infected patients starting antiretroviral therapy (ART) is limited and inconclusive.

OBJECTIVE:: We hypothesised that both vitamin and mineral deficiencies and poor appetite limit weight gain in malnourished patients starting ART and that vitamin and mineral supplementation would improve appetite and permit nutritional recovery.

DESIGN:: The randomised controlled Nutritional Support for Africans Starting Antiretroviral Therapy (NUSTART) trial was conducted in Mwanza, Tanzania and Lusaka, Zambia. ART-naïve adults referred for ART and with body mass index (BMI)<18.5 kg/m received lipid-based nutritional supplements either without (LNS) or with added vitamins and minerals (LNS-VM), beginning prior to ART initiation. Participants were given 30 g/day LNS from recruitment until 2 weeks after starting ART and 250 g/day from weeks 2-6 of ART.

RESULTS:: Of 1815 patients recruited, 365 (20%) died during the study and 813 (45%) provided data at 12 weeks. Controlling for baseline values, anthropometric measures were consistently higher at 12 weeks ART in the LNS-VM than in the LNS group but statistically significant only for calf and mid-upper-arm circumferences and triceps skinfold. Appetite did not differ between groups. Using piece-wise mixed effects quadratic models including all patients and time points, the main effects of LNS-VM were seen after starting ART and were significant for weight, BMI and mid-upper-arm circumference.

CONCLUSIONS:: Provision of high levels of vitamins and minerals to patients referred for ART, delivered with substantial macronutrients, increased nutritional recovery but did not appear to act through treatment group differences in appetite.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

TidsskriftJournal of Acquired Immune Deficiency Syndromes
Udgave nummer4
Sider (fra-til)405-412
Antal sider8
StatusUdgivet - 2015

Bibliografisk note

CURIS 2015 NEXS 092

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