Effects of dietary protein and glycaemic index on biomarkers of bone turnover in children

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Stine-Mathilde Dalskov, Martha Müller, Christian Ritz, Camilla Trab Damsgaard, Angeliki Papadaki, Wim H M Saris, Arne Astrup, Kim F. Michaelsen, Christian Mølgaard, on behalf of DiOGenes

For decades, it has been debated whether high protein intake compromises bone mineralisation, but no long-term randomised trial has investigated this in children. In the family-based, randomised controlled trial DiOGenes (Diet, Obesity and Genes), we examined the effects of dietary protein and glycaemic index (GI) on biomarkers of bone turnover and height in children aged 5-18 years. In two study centres, families with overweight parents were randomly assigned to one of five ad libitum-energy, low-fat (25-30 % energy (E%)) diets for 6 months: low protein/low GI; low protein/high GI; high protein/low GI; high protein/high GI; control. They received dietary instructions and were provided all foods for free. Children, who were eligible and willing to participate, were included in the study. In the present analyses, we included children with data on plasma osteocalcin or urinary N-terminal telopeptide of collagen type I (U-NTx) from baseline and at least one later visit (month 1 or month 6) (n 191 in total, n 67 with data on osteocalcin and n 180 with data on U-NTx). The level of osteocalcin was lower (29·1 ng/ml) in the high-protein/high-GI dietary group than in the low-protein/high-GI dietary group after 6 months of intervention (95 % CI 2·2, 56·1 ng/ml, P= 0·034). The dietary intervention did not affect U-NTx (P= 0·96) or height (P= 0·80). Baseline levels of U-NTx and osteocalcin correlated with changes in height at month 6 across the dietary groups (P
OriginalsprogEngelsk
TidsskriftBritish Journal of Nutrition
Vol/bind111
Udgave nummer7
Sider (fra-til)1253-1262
Antal sider10
ISSN0007-1145
DOI
StatusUdgivet - 2014

Bibliografisk note

CURIS 2014 NEXS 076

ID: 102786879