Effect of simethicone on lactulose-induced H2 production and gastrointestinal symptoms

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Henrik Friis, S Bodé, J J Rumessen, E Gudmand-Høyer

The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind cross-over study, 10 healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H2 and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.

OriginalsprogEngelsk
TidsskriftDigestion
Vol/bind49
Udgave nummer4
Sider (fra-til)227-230
Antal sider4
ISSN0012-2823
StatusUdgivet - 1991

ID: 119653935