Effect of fish oil supplementation on hyperlipidemia during childhood acute lymphoblastic leukemia treatment - A pilot study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Effect of fish oil supplementation on hyperlipidemia during childhood acute lymphoblastic leukemia treatment - A pilot study. / Laumann, Renate D; Iversen, Turid; Mogensen, Pernille R; Lauritzen, Lotte; Mølgaard, Christian; Frandsen, Thomas Leth.

I: Nutrition and Cancer, 2021.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Laumann, RD, Iversen, T, Mogensen, PR, Lauritzen, L, Mølgaard, C & Frandsen, TL 2021, 'Effect of fish oil supplementation on hyperlipidemia during childhood acute lymphoblastic leukemia treatment - A pilot study', Nutrition and Cancer. https://doi.org/10.1080/01635581.2020.1803934

APA

Laumann, R. D., Iversen, T., Mogensen, P. R., Lauritzen, L., Mølgaard, C., & Frandsen, T. L. (2021). Effect of fish oil supplementation on hyperlipidemia during childhood acute lymphoblastic leukemia treatment - A pilot study. Nutrition and Cancer. https://doi.org/10.1080/01635581.2020.1803934

Vancouver

Laumann RD, Iversen T, Mogensen PR, Lauritzen L, Mølgaard C, Frandsen TL. Effect of fish oil supplementation on hyperlipidemia during childhood acute lymphoblastic leukemia treatment - A pilot study. Nutrition and Cancer. 2021. https://doi.org/10.1080/01635581.2020.1803934

Author

Laumann, Renate D ; Iversen, Turid ; Mogensen, Pernille R ; Lauritzen, Lotte ; Mølgaard, Christian ; Frandsen, Thomas Leth. / Effect of fish oil supplementation on hyperlipidemia during childhood acute lymphoblastic leukemia treatment - A pilot study. I: Nutrition and Cancer. 2021.

Bibtex

@article{5a1861e3814c4d468cf1f4f80ab9277f,
title = "Effect of fish oil supplementation on hyperlipidemia during childhood acute lymphoblastic leukemia treatment - A pilot study",
abstract = "Hyperlipidemia is common during contemporary treatment of childhood acute lymphoblastic leukemia and may increase risk of osteonecrosis, thrombosis, and possibly acute pancreatitis. Marine fatty acids found in fish oil decrease levels of triglycerides and possibly total cholesterol in hyperlipidemic patients. This prospective pilot study provided fish oil for 83 days to seven children undergoing acute lymphoblastic leukemia treatment. On average fish oil was consumed 74% of the intervention period. Further, we found significant lower levels of triglycerides (P = 0.016) and total cholesterol (P = 0.027) compared to 22 historical controls, although correction for one extra PEG-asparaginase dose reduced the level of significance. However, the findings indicate that fish oil may alleviate development of hyperlipidemia during acute lymphoblastic leukemia treatment. Randomized controlled trials are warranted to confirm these findings and to investigate the potential effect of fish oil supplements on development of severe adverse events, including osteonecrosis, thrombosis, and acute pancreatitis.",
keywords = "Faculty of Science, Acute lymphoblastic leukaemia (ALL), Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA), Fish oil (FO), Total cholesterol (TC), Triglyceride (TG)",
author = "Laumann, {Renate D} and Turid Iversen and Mogensen, {Pernille R} and Lotte Lauritzen and Christian M{\o}lgaard and Frandsen, {Thomas Leth}",
note = "(CURIS 2020 NEXS 256) --> 2021 (02.06.2021) Oprindelig publiceret: 13. august 2020",
year = "2021",
doi = "10.1080/01635581.2020.1803934",
language = "English",
journal = "Nutrition and Cancer",
issn = "0163-5581",
publisher = "Taylor & Francis",

}

RIS

TY - JOUR

T1 - Effect of fish oil supplementation on hyperlipidemia during childhood acute lymphoblastic leukemia treatment - A pilot study

AU - Laumann, Renate D

AU - Iversen, Turid

AU - Mogensen, Pernille R

AU - Lauritzen, Lotte

AU - Mølgaard, Christian

AU - Frandsen, Thomas Leth

N1 - (CURIS 2020 NEXS 256) --> 2021 (02.06.2021) Oprindelig publiceret: 13. august 2020

PY - 2021

Y1 - 2021

N2 - Hyperlipidemia is common during contemporary treatment of childhood acute lymphoblastic leukemia and may increase risk of osteonecrosis, thrombosis, and possibly acute pancreatitis. Marine fatty acids found in fish oil decrease levels of triglycerides and possibly total cholesterol in hyperlipidemic patients. This prospective pilot study provided fish oil for 83 days to seven children undergoing acute lymphoblastic leukemia treatment. On average fish oil was consumed 74% of the intervention period. Further, we found significant lower levels of triglycerides (P = 0.016) and total cholesterol (P = 0.027) compared to 22 historical controls, although correction for one extra PEG-asparaginase dose reduced the level of significance. However, the findings indicate that fish oil may alleviate development of hyperlipidemia during acute lymphoblastic leukemia treatment. Randomized controlled trials are warranted to confirm these findings and to investigate the potential effect of fish oil supplements on development of severe adverse events, including osteonecrosis, thrombosis, and acute pancreatitis.

AB - Hyperlipidemia is common during contemporary treatment of childhood acute lymphoblastic leukemia and may increase risk of osteonecrosis, thrombosis, and possibly acute pancreatitis. Marine fatty acids found in fish oil decrease levels of triglycerides and possibly total cholesterol in hyperlipidemic patients. This prospective pilot study provided fish oil for 83 days to seven children undergoing acute lymphoblastic leukemia treatment. On average fish oil was consumed 74% of the intervention period. Further, we found significant lower levels of triglycerides (P = 0.016) and total cholesterol (P = 0.027) compared to 22 historical controls, although correction for one extra PEG-asparaginase dose reduced the level of significance. However, the findings indicate that fish oil may alleviate development of hyperlipidemia during acute lymphoblastic leukemia treatment. Randomized controlled trials are warranted to confirm these findings and to investigate the potential effect of fish oil supplements on development of severe adverse events, including osteonecrosis, thrombosis, and acute pancreatitis.

KW - Faculty of Science

KW - Acute lymphoblastic leukaemia (ALL)

KW - Docosahexaenoic acid (DHA)

KW - Eicosapentaenoic acid (EPA)

KW - Fish oil (FO)

KW - Total cholesterol (TC)

KW - Triglyceride (TG)

U2 - 10.1080/01635581.2020.1803934

DO - 10.1080/01635581.2020.1803934

M3 - Journal article

C2 - 32791015

JO - Nutrition and Cancer

JF - Nutrition and Cancer

SN - 0163-5581

ER -

ID: 247034071