Diabetes prevalence by HbA1c and oral glucose tolerance test among HIV-infected and uninfected Tanzanian adults

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Diabetes prevalence by HbA1c and oral glucose tolerance test among HIV-infected and uninfected Tanzanian adults. / Jeremiah, Kidola; Filteau, Suzanne; Faurholt-Jepsen, Daniel; Kitilya, Brenda; Kavishe, Bazil Baltazar; Krogh-Madsen, Rikke; Olsen, Mette Frahm; Changalucha, John; Rehman, Andrea M; Range, Nyagosya; Kamwela, Jerome; Ramaiya, Kaushik; Andersen, Aase Bengård; Friis, Henrik; Heimburger, Douglas C; PrayGod, George.

I: P L o S One, Bind 15, Nr. 4, e0230723, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Jeremiah, K, Filteau, S, Faurholt-Jepsen, D, Kitilya, B, Kavishe, BB, Krogh-Madsen, R, Olsen, MF, Changalucha, J, Rehman, AM, Range, N, Kamwela, J, Ramaiya, K, Andersen, AB, Friis, H, Heimburger, DC & PrayGod, G 2020, 'Diabetes prevalence by HbA1c and oral glucose tolerance test among HIV-infected and uninfected Tanzanian adults', P L o S One, bind 15, nr. 4, e0230723. https://doi.org/10.1371/journal.pone.0230723

APA

Jeremiah, K., Filteau, S., Faurholt-Jepsen, D., Kitilya, B., Kavishe, B. B., Krogh-Madsen, R., ... PrayGod, G. (2020). Diabetes prevalence by HbA1c and oral glucose tolerance test among HIV-infected and uninfected Tanzanian adults. P L o S One, 15(4), [e0230723]. https://doi.org/10.1371/journal.pone.0230723

Vancouver

Jeremiah K, Filteau S, Faurholt-Jepsen D, Kitilya B, Kavishe BB, Krogh-Madsen R o.a. Diabetes prevalence by HbA1c and oral glucose tolerance test among HIV-infected and uninfected Tanzanian adults. P L o S One. 2020;15(4). e0230723. https://doi.org/10.1371/journal.pone.0230723

Author

Jeremiah, Kidola ; Filteau, Suzanne ; Faurholt-Jepsen, Daniel ; Kitilya, Brenda ; Kavishe, Bazil Baltazar ; Krogh-Madsen, Rikke ; Olsen, Mette Frahm ; Changalucha, John ; Rehman, Andrea M ; Range, Nyagosya ; Kamwela, Jerome ; Ramaiya, Kaushik ; Andersen, Aase Bengård ; Friis, Henrik ; Heimburger, Douglas C ; PrayGod, George. / Diabetes prevalence by HbA1c and oral glucose tolerance test among HIV-infected and uninfected Tanzanian adults. I: P L o S One. 2020 ; Bind 15, Nr. 4.

Bibtex

@article{9d8a037d26a44ce598458f126c7bb9d5,
title = "Diabetes prevalence by HbA1c and oral glucose tolerance test among HIV-infected and uninfected Tanzanian adults",
abstract = "Background: The burden of diabetes is increasing in sub-Saharan Africa, including among people living with HIV. We assessed the prevalence of diabetes and the roles of HIV, antiretroviral therapy (ART) and traditional risk factors among adults in Tanzania.Methods: We analysed diabetes-relevant baseline data from 1,947 adult participants in the CICADA study in Mwanza, Tanzania: 655 HIV-uninfected, 956 HIV-infected ART-na{\"i}ve, and 336 HIV-infected persons on ART. WHO guidelines for haemoglobin A1c (HbA1c) and oral glucose tolerance test (OGTT) were used to define diabetes and prediabetes. Risk factors were evaluated using multinomial logistic regression analysis. Relative risk ratios (RRR) were generated comparing participants with diabetes and prediabetes against the reference of those with no diabetes.Results: Mean age was 41 (SD 12) years; 59{\%} were women. The prevalence of diabetes was 13{\%} by HbA1c and 6{\%} by OGTT, with partial overlap among participants identified by the two tests. Relative to HIV-uninfected, HIV-infected ART-na{\"i}ve persons had increased relative risks of diabetes (HbA1c: RRR = 1.95, 95{\%} CI 1.25-3.03; OGTT: RRR = 1.90, 95{\%} CI 0.96-3.73) and prediabetes (HbA1c: RRR = 2.89, 95{\%} CI 1.93-4.34; OGTT: RRR = 1.61, 95{\%} CI 1.22-2.13). HIV-infected participants on ART showed increased risk of prediabetes (RRR 1.80, 95{\%} CI 1.09, 2.94) by HbA1c, but not diabetes. CD4 count < 200 cell/μL at recruitment increased risk and physical activity decreased risk of diabetes by both HbA1c and OGTT.Conclusions: The prevalence of diabetes was high, especially among HIV-infected ART-na{\"i}ve adults. Being more physically active was associated with lower risk of diabetes. HbA1c and OGTT identified different participants as having diabetes or prediabetes. Overall, the finding of high burden of diabetes among HIV-infected persons suggests that health systems should consider integrating diabetes screening and treatment in HIV clinics to optimize the care of HIV patients and improve their health outcomes.",
author = "Kidola Jeremiah and Suzanne Filteau and Daniel Faurholt-Jepsen and Brenda Kitilya and Kavishe, {Bazil Baltazar} and Rikke Krogh-Madsen and Olsen, {Mette Frahm} and John Changalucha and Rehman, {Andrea M} and Nyagosya Range and Jerome Kamwela and Kaushik Ramaiya and Andersen, {Aase Beng{\aa}rd} and Henrik Friis and Heimburger, {Douglas C} and George PrayGod",
note = "CURIS 2020 NEXS 123",
year = "2020",
doi = "10.1371/journal.pone.0230723",
language = "English",
volume = "15",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - Diabetes prevalence by HbA1c and oral glucose tolerance test among HIV-infected and uninfected Tanzanian adults

AU - Jeremiah, Kidola

AU - Filteau, Suzanne

AU - Faurholt-Jepsen, Daniel

AU - Kitilya, Brenda

AU - Kavishe, Bazil Baltazar

AU - Krogh-Madsen, Rikke

AU - Olsen, Mette Frahm

AU - Changalucha, John

AU - Rehman, Andrea M

AU - Range, Nyagosya

AU - Kamwela, Jerome

AU - Ramaiya, Kaushik

AU - Andersen, Aase Bengård

AU - Friis, Henrik

AU - Heimburger, Douglas C

AU - PrayGod, George

N1 - CURIS 2020 NEXS 123

PY - 2020

Y1 - 2020

N2 - Background: The burden of diabetes is increasing in sub-Saharan Africa, including among people living with HIV. We assessed the prevalence of diabetes and the roles of HIV, antiretroviral therapy (ART) and traditional risk factors among adults in Tanzania.Methods: We analysed diabetes-relevant baseline data from 1,947 adult participants in the CICADA study in Mwanza, Tanzania: 655 HIV-uninfected, 956 HIV-infected ART-naïve, and 336 HIV-infected persons on ART. WHO guidelines for haemoglobin A1c (HbA1c) and oral glucose tolerance test (OGTT) were used to define diabetes and prediabetes. Risk factors were evaluated using multinomial logistic regression analysis. Relative risk ratios (RRR) were generated comparing participants with diabetes and prediabetes against the reference of those with no diabetes.Results: Mean age was 41 (SD 12) years; 59% were women. The prevalence of diabetes was 13% by HbA1c and 6% by OGTT, with partial overlap among participants identified by the two tests. Relative to HIV-uninfected, HIV-infected ART-naïve persons had increased relative risks of diabetes (HbA1c: RRR = 1.95, 95% CI 1.25-3.03; OGTT: RRR = 1.90, 95% CI 0.96-3.73) and prediabetes (HbA1c: RRR = 2.89, 95% CI 1.93-4.34; OGTT: RRR = 1.61, 95% CI 1.22-2.13). HIV-infected participants on ART showed increased risk of prediabetes (RRR 1.80, 95% CI 1.09, 2.94) by HbA1c, but not diabetes. CD4 count < 200 cell/μL at recruitment increased risk and physical activity decreased risk of diabetes by both HbA1c and OGTT.Conclusions: The prevalence of diabetes was high, especially among HIV-infected ART-naïve adults. Being more physically active was associated with lower risk of diabetes. HbA1c and OGTT identified different participants as having diabetes or prediabetes. Overall, the finding of high burden of diabetes among HIV-infected persons suggests that health systems should consider integrating diabetes screening and treatment in HIV clinics to optimize the care of HIV patients and improve their health outcomes.

AB - Background: The burden of diabetes is increasing in sub-Saharan Africa, including among people living with HIV. We assessed the prevalence of diabetes and the roles of HIV, antiretroviral therapy (ART) and traditional risk factors among adults in Tanzania.Methods: We analysed diabetes-relevant baseline data from 1,947 adult participants in the CICADA study in Mwanza, Tanzania: 655 HIV-uninfected, 956 HIV-infected ART-naïve, and 336 HIV-infected persons on ART. WHO guidelines for haemoglobin A1c (HbA1c) and oral glucose tolerance test (OGTT) were used to define diabetes and prediabetes. Risk factors were evaluated using multinomial logistic regression analysis. Relative risk ratios (RRR) were generated comparing participants with diabetes and prediabetes against the reference of those with no diabetes.Results: Mean age was 41 (SD 12) years; 59% were women. The prevalence of diabetes was 13% by HbA1c and 6% by OGTT, with partial overlap among participants identified by the two tests. Relative to HIV-uninfected, HIV-infected ART-naïve persons had increased relative risks of diabetes (HbA1c: RRR = 1.95, 95% CI 1.25-3.03; OGTT: RRR = 1.90, 95% CI 0.96-3.73) and prediabetes (HbA1c: RRR = 2.89, 95% CI 1.93-4.34; OGTT: RRR = 1.61, 95% CI 1.22-2.13). HIV-infected participants on ART showed increased risk of prediabetes (RRR 1.80, 95% CI 1.09, 2.94) by HbA1c, but not diabetes. CD4 count < 200 cell/μL at recruitment increased risk and physical activity decreased risk of diabetes by both HbA1c and OGTT.Conclusions: The prevalence of diabetes was high, especially among HIV-infected ART-naïve adults. Being more physically active was associated with lower risk of diabetes. HbA1c and OGTT identified different participants as having diabetes or prediabetes. Overall, the finding of high burden of diabetes among HIV-infected persons suggests that health systems should consider integrating diabetes screening and treatment in HIV clinics to optimize the care of HIV patients and improve their health outcomes.

U2 - 10.1371/journal.pone.0230723

DO - 10.1371/journal.pone.0230723

M3 - Journal article

C2 - 32267855

VL - 15

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 4

M1 - e0230723

ER -

ID: 240793398