Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety

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Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety. / Sparre, Anita Belza; Ritz, Christian; Sørensen, Mejse Q; Holst, Jens Juul; Rehfeld, Jens Frederik; Astrup, Arne.

I: American Journal of Clinical Nutrition, Bind 97, Nr. 5, 2013, s. 980-989.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Sparre, AB, Ritz, C, Sørensen, MQ, Holst, JJ, Rehfeld, JF & Astrup, A 2013, 'Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety', American Journal of Clinical Nutrition, bind 97, nr. 5, s. 980-989. https://doi.org/10.3945/ajcn.112.047563

APA

Sparre, A. B., Ritz, C., Sørensen, M. Q., Holst, J. J., Rehfeld, J. F., & Astrup, A. (2013). Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety. American Journal of Clinical Nutrition, 97(5), 980-989. https://doi.org/10.3945/ajcn.112.047563

Vancouver

Sparre AB, Ritz C, Sørensen MQ, Holst JJ, Rehfeld JF, Astrup A. Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety. American Journal of Clinical Nutrition. 2013;97(5):980-989. https://doi.org/10.3945/ajcn.112.047563

Author

Sparre, Anita Belza ; Ritz, Christian ; Sørensen, Mejse Q ; Holst, Jens Juul ; Rehfeld, Jens Frederik ; Astrup, Arne. / Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety. I: American Journal of Clinical Nutrition. 2013 ; Bind 97, Nr. 5. s. 980-989.

Bibtex

@article{c75c614a3a6d436fa5bac3d556c79029,
title = "Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety",
abstract = "BACKGROUND: Effects of protein intake on appetite-regulating hormones and their dynamics are unclear. OBJECTIVES: We investigated the satiating effects of meals with varying protein contents and whether there was an effect of dose on appetite-regulating hormones and appetite ratings.Design: Twenty-five men [mean ± SD age: 30.0 ± 8.7 y; body mass index (BMI; in kg/m(2)): 25.9 ± 4.7] participated in the 3-way, randomized, double-blind crossover study. Test meals were isocaloric with 30{\%} of energy from fat and protein content adjusted at the expense of carbohydrate. Test meals were normal protein (NP; 14{\%} of energy from protein), medium-high protein (MHP; 25{\%} of energy from protein), and high protein (HP, 50{\%} of energy from protein). Appetite ratings and blood samples were assessed every 0.5 h for 4 h. An ad libitum lunch was served 4 h after the meal. RESULTS: Protein increased dose-dependently glucagon-like peptide-1 (GLP-1), peptide YY (PYY) 3-36, and glucagon; MHP produced 10{\%}, 7{\%}, and 47{\%} greater responses, respectively; and HP produced 20{\%}, 14{\%}, and 116{\%} greater responses, respectively, than did NP (P <0.03). Compared with NP, HP increased insulin and cholecystokinin and decreased ghrelin and glucose-dependent insulinotropic polypeptide (P <0.05). Satiety and fullness dose-dependently increased by 7{\%} and 6{\%} for MHP and 16{\%} and 19{\%} for HP compared with NP (P <0.001). Hunger and prospective consumption dose-dependently decreased by 15{\%} and 13{\%} for MHP and by 25{\%} and 26{\%} for HP compared with NP (P <0.0003). There was a combined effect of GLP-1 and PYY 3-36 (P = 0.03) next to the additive effect of GLP-1 (P = 0.006) on the composite appetite score. No difference was shown in ad libitum energy intake. CONCLUSION: Protein dose-dependently increased satiety and GLP-1, PYY 3-36, and glucagon, which may, at least in part, be responsible for the satiety-stimulating effect of protein. This trial was registered at clinicaltrials.gov as NCT01561235.",
author = "Sparre, {Anita Belza} and Christian Ritz and S{\o}rensen, {Mejse Q} and Holst, {Jens Juul} and Rehfeld, {Jens Frederik} and Arne Astrup",
note = "CURIS 2013 NEXS 053",
year = "2013",
doi = "10.3945/ajcn.112.047563",
language = "English",
volume = "97",
pages = "980--989",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

RIS

TY - JOUR

T1 - Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety

AU - Sparre, Anita Belza

AU - Ritz, Christian

AU - Sørensen, Mejse Q

AU - Holst, Jens Juul

AU - Rehfeld, Jens Frederik

AU - Astrup, Arne

N1 - CURIS 2013 NEXS 053

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Effects of protein intake on appetite-regulating hormones and their dynamics are unclear. OBJECTIVES: We investigated the satiating effects of meals with varying protein contents and whether there was an effect of dose on appetite-regulating hormones and appetite ratings.Design: Twenty-five men [mean ± SD age: 30.0 ± 8.7 y; body mass index (BMI; in kg/m(2)): 25.9 ± 4.7] participated in the 3-way, randomized, double-blind crossover study. Test meals were isocaloric with 30% of energy from fat and protein content adjusted at the expense of carbohydrate. Test meals were normal protein (NP; 14% of energy from protein), medium-high protein (MHP; 25% of energy from protein), and high protein (HP, 50% of energy from protein). Appetite ratings and blood samples were assessed every 0.5 h for 4 h. An ad libitum lunch was served 4 h after the meal. RESULTS: Protein increased dose-dependently glucagon-like peptide-1 (GLP-1), peptide YY (PYY) 3-36, and glucagon; MHP produced 10%, 7%, and 47% greater responses, respectively; and HP produced 20%, 14%, and 116% greater responses, respectively, than did NP (P <0.03). Compared with NP, HP increased insulin and cholecystokinin and decreased ghrelin and glucose-dependent insulinotropic polypeptide (P <0.05). Satiety and fullness dose-dependently increased by 7% and 6% for MHP and 16% and 19% for HP compared with NP (P <0.001). Hunger and prospective consumption dose-dependently decreased by 15% and 13% for MHP and by 25% and 26% for HP compared with NP (P <0.0003). There was a combined effect of GLP-1 and PYY 3-36 (P = 0.03) next to the additive effect of GLP-1 (P = 0.006) on the composite appetite score. No difference was shown in ad libitum energy intake. CONCLUSION: Protein dose-dependently increased satiety and GLP-1, PYY 3-36, and glucagon, which may, at least in part, be responsible for the satiety-stimulating effect of protein. This trial was registered at clinicaltrials.gov as NCT01561235.

AB - BACKGROUND: Effects of protein intake on appetite-regulating hormones and their dynamics are unclear. OBJECTIVES: We investigated the satiating effects of meals with varying protein contents and whether there was an effect of dose on appetite-regulating hormones and appetite ratings.Design: Twenty-five men [mean ± SD age: 30.0 ± 8.7 y; body mass index (BMI; in kg/m(2)): 25.9 ± 4.7] participated in the 3-way, randomized, double-blind crossover study. Test meals were isocaloric with 30% of energy from fat and protein content adjusted at the expense of carbohydrate. Test meals were normal protein (NP; 14% of energy from protein), medium-high protein (MHP; 25% of energy from protein), and high protein (HP, 50% of energy from protein). Appetite ratings and blood samples were assessed every 0.5 h for 4 h. An ad libitum lunch was served 4 h after the meal. RESULTS: Protein increased dose-dependently glucagon-like peptide-1 (GLP-1), peptide YY (PYY) 3-36, and glucagon; MHP produced 10%, 7%, and 47% greater responses, respectively; and HP produced 20%, 14%, and 116% greater responses, respectively, than did NP (P <0.03). Compared with NP, HP increased insulin and cholecystokinin and decreased ghrelin and glucose-dependent insulinotropic polypeptide (P <0.05). Satiety and fullness dose-dependently increased by 7% and 6% for MHP and 16% and 19% for HP compared with NP (P <0.001). Hunger and prospective consumption dose-dependently decreased by 15% and 13% for MHP and by 25% and 26% for HP compared with NP (P <0.0003). There was a combined effect of GLP-1 and PYY 3-36 (P = 0.03) next to the additive effect of GLP-1 (P = 0.006) on the composite appetite score. No difference was shown in ad libitum energy intake. CONCLUSION: Protein dose-dependently increased satiety and GLP-1, PYY 3-36, and glucagon, which may, at least in part, be responsible for the satiety-stimulating effect of protein. This trial was registered at clinicaltrials.gov as NCT01561235.

U2 - 10.3945/ajcn.112.047563

DO - 10.3945/ajcn.112.047563

M3 - Journal article

C2 - 23466396

VL - 97

SP - 980

EP - 989

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -

ID: 44853221