Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes

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Standard

Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes. / Petersen, Rikke Agnete; Larsen, Lesli Hingstrup; Damsgaard, Camilla Trab; Sørensen, Louise Bergmann; Hjorth, Mads Fiil; Andersen, Rikke; Tetens, Inge; Krarup, Henrik; Ritz, Christian; Astrup, Arne; Michaelsen, Kim F.; Mølgaard, Christian.

I: British Journal of Nutrition, Bind 117, Nr. 6, 2017, s. 829-838.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Petersen, RA, Larsen, LH, Damsgaard, CT, Sørensen, LB, Hjorth, MF, Andersen, R, Tetens, I, Krarup, H, Ritz, C, Astrup, A, Michaelsen, KF & Mølgaard, C 2017, 'Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes', British Journal of Nutrition, bind 117, nr. 6, s. 829-838. https://doi.org/10.1017/S0007114517000538

APA

Petersen, R. A., Larsen, L. H., Damsgaard, C. T., Sørensen, L. B., Hjorth, M. F., Andersen, R., ... Mølgaard, C. (2017). Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes. British Journal of Nutrition, 117(6), 829-838. https://doi.org/10.1017/S0007114517000538

Vancouver

Petersen RA, Larsen LH, Damsgaard CT, Sørensen LB, Hjorth MF, Andersen R o.a. Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes. British Journal of Nutrition. 2017;117(6):829-838. https://doi.org/10.1017/S0007114517000538

Author

Petersen, Rikke Agnete ; Larsen, Lesli Hingstrup ; Damsgaard, Camilla Trab ; Sørensen, Louise Bergmann ; Hjorth, Mads Fiil ; Andersen, Rikke ; Tetens, Inge ; Krarup, Henrik ; Ritz, Christian ; Astrup, Arne ; Michaelsen, Kim F. ; Mølgaard, Christian. / Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes. I: British Journal of Nutrition. 2017 ; Bind 117, Nr. 6. s. 829-838.

Bibtex

@article{d7dd52e1a4f64805b2037583d470cdb5,
title = "Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes",
abstract = "In a longitudinal study including 642 healthy 8-11-year-old Danish children, we investigated associations between vitamin D dependent SNP and serum 25-hydroxyvitamin D (25(OH)D) concentrations across a school year (August-June). Serum 25(OH)D was measured three times for every child, which approximated measurements in three seasons (autumn, winter, spring). Dietary and supplement intake, physical activity, BMI and parathyroid hormone were likewise measured at each time point. In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (CYP2R1); 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase-1(DHCR7/NADSYN1); group-specific complement (GC); and vitamin D receptor were genotyped. We found minor alleles of CYP2R1 rs10500804, and of GC rs4588 and rs7041 to be associated with lower serum 25(OH)D concentrations across the three seasons (all P<0·01), with estimated 25(OH)D differences of -5·8 to -10·6 nmol/l from major to minor alleles homozygosity. In contrast, minor alleles homozygosity of rs10741657 and rs1562902 in CYP2R1 was associated with higher serum 25(OH)D concentrations compared with major alleles homozygosity (all P<0·001). Interestingly, the association between season and serum 25(OH)D concentrations was modified by GC rs7041 (P interaction=0·044), observed as absence of increase in serum 25(OH)D from winter to spring among children with minor alleles homozygous genotypes compared with the two other genotypes of rs7041 (P<0·001). Our results suggest that common genetic variants are associated with lower serum 25(OH)D concentrations across a school year. Potentially due to modified serum 25(OH)D response to UVB sunlight exposure. Further confirmation and paediatric studies investigating vitamin D-related health outcomes of these genotypic differences are needed.",
keywords = "Vitamin D, Genetic variations, Children, Northern latitudes",
author = "Petersen, {Rikke Agnete} and Larsen, {Lesli Hingstrup} and Damsgaard, {Camilla Trab} and S{\o}rensen, {Louise Bergmann} and Hjorth, {Mads Fiil} and Rikke Andersen and Inge Tetens and Henrik Krarup and Christian Ritz and Arne Astrup and Michaelsen, {Kim F.} and Christian M{\o}lgaard",
note = "CURIS 2017 NEXS 111",
year = "2017",
doi = "10.1017/S0007114517000538",
language = "English",
volume = "117",
pages = "829--838",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes

AU - Petersen, Rikke Agnete

AU - Larsen, Lesli Hingstrup

AU - Damsgaard, Camilla Trab

AU - Sørensen, Louise Bergmann

AU - Hjorth, Mads Fiil

AU - Andersen, Rikke

AU - Tetens, Inge

AU - Krarup, Henrik

AU - Ritz, Christian

AU - Astrup, Arne

AU - Michaelsen, Kim F.

AU - Mølgaard, Christian

N1 - CURIS 2017 NEXS 111

PY - 2017

Y1 - 2017

N2 - In a longitudinal study including 642 healthy 8-11-year-old Danish children, we investigated associations between vitamin D dependent SNP and serum 25-hydroxyvitamin D (25(OH)D) concentrations across a school year (August-June). Serum 25(OH)D was measured three times for every child, which approximated measurements in three seasons (autumn, winter, spring). Dietary and supplement intake, physical activity, BMI and parathyroid hormone were likewise measured at each time point. In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (CYP2R1); 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase-1(DHCR7/NADSYN1); group-specific complement (GC); and vitamin D receptor were genotyped. We found minor alleles of CYP2R1 rs10500804, and of GC rs4588 and rs7041 to be associated with lower serum 25(OH)D concentrations across the three seasons (all P<0·01), with estimated 25(OH)D differences of -5·8 to -10·6 nmol/l from major to minor alleles homozygosity. In contrast, minor alleles homozygosity of rs10741657 and rs1562902 in CYP2R1 was associated with higher serum 25(OH)D concentrations compared with major alleles homozygosity (all P<0·001). Interestingly, the association between season and serum 25(OH)D concentrations was modified by GC rs7041 (P interaction=0·044), observed as absence of increase in serum 25(OH)D from winter to spring among children with minor alleles homozygous genotypes compared with the two other genotypes of rs7041 (P<0·001). Our results suggest that common genetic variants are associated with lower serum 25(OH)D concentrations across a school year. Potentially due to modified serum 25(OH)D response to UVB sunlight exposure. Further confirmation and paediatric studies investigating vitamin D-related health outcomes of these genotypic differences are needed.

AB - In a longitudinal study including 642 healthy 8-11-year-old Danish children, we investigated associations between vitamin D dependent SNP and serum 25-hydroxyvitamin D (25(OH)D) concentrations across a school year (August-June). Serum 25(OH)D was measured three times for every child, which approximated measurements in three seasons (autumn, winter, spring). Dietary and supplement intake, physical activity, BMI and parathyroid hormone were likewise measured at each time point. In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (CYP2R1); 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase-1(DHCR7/NADSYN1); group-specific complement (GC); and vitamin D receptor were genotyped. We found minor alleles of CYP2R1 rs10500804, and of GC rs4588 and rs7041 to be associated with lower serum 25(OH)D concentrations across the three seasons (all P<0·01), with estimated 25(OH)D differences of -5·8 to -10·6 nmol/l from major to minor alleles homozygosity. In contrast, minor alleles homozygosity of rs10741657 and rs1562902 in CYP2R1 was associated with higher serum 25(OH)D concentrations compared with major alleles homozygosity (all P<0·001). Interestingly, the association between season and serum 25(OH)D concentrations was modified by GC rs7041 (P interaction=0·044), observed as absence of increase in serum 25(OH)D from winter to spring among children with minor alleles homozygous genotypes compared with the two other genotypes of rs7041 (P<0·001). Our results suggest that common genetic variants are associated with lower serum 25(OH)D concentrations across a school year. Potentially due to modified serum 25(OH)D response to UVB sunlight exposure. Further confirmation and paediatric studies investigating vitamin D-related health outcomes of these genotypic differences are needed.

KW - Vitamin D

KW - Genetic variations

KW - Children

KW - Northern latitudes

U2 - 10.1017/S0007114517000538

DO - 10.1017/S0007114517000538

M3 - Journal article

C2 - 28382877

VL - 117

SP - 829

EP - 838

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 6

ER -

ID: 176620361