Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure : an individual participant meta-analysis. / van Rossem, Lenie; Smit, Henriette A; Armand, Martine; Bernard, Jonathan Y; Bisgaard, Hans; Bønnelykke, Klaus; Bruun, Signe; Heude, Barbara; Husby, Steffen; Kyhl, Henriette Boye; Michaelsen, Kim F.; Stark, Ken D; Thijs, Carel; Vinding, Rebecca Kofod; Wijga, Alet H; Lauritzen, Lotte.

I: European Journal of Nutrition, 20.06.2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

van Rossem, L, Smit, HA, Armand, M, Bernard, JY, Bisgaard, H, Bønnelykke, K, Bruun, S, Heude, B, Husby, S, Kyhl, HB, Michaelsen, KF, Stark, KD, Thijs, C, Vinding, RK, Wijga, AH & Lauritzen, L 2020, 'Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis', European Journal of Nutrition. https://doi.org/10.1007/s00394-020-02310-4

APA

van Rossem, L., Smit, H. A., Armand, M., Bernard, J. Y., Bisgaard, H., Bønnelykke, K., ... Lauritzen, L. (2020). Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis. European Journal of Nutrition. https://doi.org/10.1007/s00394-020-02310-4

Vancouver

van Rossem L, Smit HA, Armand M, Bernard JY, Bisgaard H, Bønnelykke K o.a. Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis. European Journal of Nutrition. 2020 jun 20. https://doi.org/10.1007/s00394-020-02310-4

Author

van Rossem, Lenie ; Smit, Henriette A ; Armand, Martine ; Bernard, Jonathan Y ; Bisgaard, Hans ; Bønnelykke, Klaus ; Bruun, Signe ; Heude, Barbara ; Husby, Steffen ; Kyhl, Henriette Boye ; Michaelsen, Kim F. ; Stark, Ken D ; Thijs, Carel ; Vinding, Rebecca Kofod ; Wijga, Alet H ; Lauritzen, Lotte. / Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure : an individual participant meta-analysis. I: European Journal of Nutrition. 2020.

Bibtex

@article{4735ab3bc5c34281b70e05e13bc4c3bc,
title = "Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis",
abstract = "Purpose: It is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven European birth cohorts.Methods: We searched https://www.birthcohort.net for studies that had collected breast milk samples, and had at least one BP measurement in childhood. Principal investigators were contacted, and all agreed to share data. One additional study was identified by contacts with the principal investigators. For each cohort, we analyzed the association of breast milk n-3 LC PUFAs with systolic and diastolic BP with linear mixed effects models or linear regression, and pooled the estimates with a random effects model. We also investigated age-specific and sex-specific associations.Results: A total of 2188 participants from 7 cohorts were included. Overall, no associations between breast milk n-3 LC PUFAs and BP were observed. In the pooled analysis, each 0.1 wt{\%} increment in breast milk docosahexaenoic acid (DHA) was associated with a 1.19 (95{\%} CI - 3.31, 0.94) mmHg lower systolic BP. Associations were similar for boys and girls and at different ages.Conclusion: In this individual participant meta-analysis, we found no evidence for an association between breast milk n-3 LC PUFAs and BP.",
keywords = "Faculty of Science, Breastfeeding, Blood pressure, Fatty acids, Children",
author = "{van Rossem}, Lenie and Smit, {Henriette A} and Martine Armand and Bernard, {Jonathan Y} and Hans Bisgaard and Klaus B{\o}nnelykke and Signe Bruun and Barbara Heude and Steffen Husby and Kyhl, {Henriette Boye} and Michaelsen, {Kim F.} and Stark, {Ken D} and Carel Thijs and Vinding, {Rebecca Kofod} and Wijga, {Alet H} and Lotte Lauritzen",
note = "CURIS 2020 NEXS 198 (Open Access --> upload pdf-fil)",
year = "2020",
month = "6",
day = "20",
doi = "10.1007/s00394-020-02310-4",
language = "English",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "Springer Medizin",

}

RIS

TY - JOUR

T1 - Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure

T2 - an individual participant meta-analysis

AU - van Rossem, Lenie

AU - Smit, Henriette A

AU - Armand, Martine

AU - Bernard, Jonathan Y

AU - Bisgaard, Hans

AU - Bønnelykke, Klaus

AU - Bruun, Signe

AU - Heude, Barbara

AU - Husby, Steffen

AU - Kyhl, Henriette Boye

AU - Michaelsen, Kim F.

AU - Stark, Ken D

AU - Thijs, Carel

AU - Vinding, Rebecca Kofod

AU - Wijga, Alet H

AU - Lauritzen, Lotte

N1 - CURIS 2020 NEXS 198 (Open Access --> upload pdf-fil)

PY - 2020/6/20

Y1 - 2020/6/20

N2 - Purpose: It is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven European birth cohorts.Methods: We searched https://www.birthcohort.net for studies that had collected breast milk samples, and had at least one BP measurement in childhood. Principal investigators were contacted, and all agreed to share data. One additional study was identified by contacts with the principal investigators. For each cohort, we analyzed the association of breast milk n-3 LC PUFAs with systolic and diastolic BP with linear mixed effects models or linear regression, and pooled the estimates with a random effects model. We also investigated age-specific and sex-specific associations.Results: A total of 2188 participants from 7 cohorts were included. Overall, no associations between breast milk n-3 LC PUFAs and BP were observed. In the pooled analysis, each 0.1 wt% increment in breast milk docosahexaenoic acid (DHA) was associated with a 1.19 (95% CI - 3.31, 0.94) mmHg lower systolic BP. Associations were similar for boys and girls and at different ages.Conclusion: In this individual participant meta-analysis, we found no evidence for an association between breast milk n-3 LC PUFAs and BP.

AB - Purpose: It is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven European birth cohorts.Methods: We searched https://www.birthcohort.net for studies that had collected breast milk samples, and had at least one BP measurement in childhood. Principal investigators were contacted, and all agreed to share data. One additional study was identified by contacts with the principal investigators. For each cohort, we analyzed the association of breast milk n-3 LC PUFAs with systolic and diastolic BP with linear mixed effects models or linear regression, and pooled the estimates with a random effects model. We also investigated age-specific and sex-specific associations.Results: A total of 2188 participants from 7 cohorts were included. Overall, no associations between breast milk n-3 LC PUFAs and BP were observed. In the pooled analysis, each 0.1 wt% increment in breast milk docosahexaenoic acid (DHA) was associated with a 1.19 (95% CI - 3.31, 0.94) mmHg lower systolic BP. Associations were similar for boys and girls and at different ages.Conclusion: In this individual participant meta-analysis, we found no evidence for an association between breast milk n-3 LC PUFAs and BP.

KW - Faculty of Science

KW - Breastfeeding

KW - Blood pressure

KW - Fatty acids

KW - Children

U2 - 10.1007/s00394-020-02310-4

DO - 10.1007/s00394-020-02310-4

M3 - Journal article

C2 - 32564149

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

ER -

ID: 243342452