Biochemical and anthropometric correlates of bio-electrical impedance parameters in severely malnourished children: A cross-sectional study

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Biochemical and anthropometric correlates of bio-electrical impedance parameters in severely malnourished children : A cross-sectional study. / Girma, Tsinuel; Nielsen, Anne-Louise Hother; Kæstel, Pernille; Abdissa, Alemseged; Michaelsen, Kim F.; Friis, Henrik; Wells, Jonathan C.

I: Clinical Nutrition, Bind 37, Nr. 2, 2018, s. 701-705.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Girma, T, Nielsen, A-LH, Kæstel, P, Abdissa, A, Michaelsen, KF, Friis, H & Wells, JC 2018, 'Biochemical and anthropometric correlates of bio-electrical impedance parameters in severely malnourished children: A cross-sectional study', Clinical Nutrition, bind 37, nr. 2, s. 701-705. https://doi.org/10.1016/j.clnu.2017.02.017

APA

Girma, T., Nielsen, A-L. H., Kæstel, P., Abdissa, A., Michaelsen, K. F., Friis, H., & Wells, J. C. (2018). Biochemical and anthropometric correlates of bio-electrical impedance parameters in severely malnourished children: A cross-sectional study. Clinical Nutrition, 37(2), 701-705. https://doi.org/10.1016/j.clnu.2017.02.017

Vancouver

Girma T, Nielsen A-LH, Kæstel P, Abdissa A, Michaelsen KF, Friis H o.a. Biochemical and anthropometric correlates of bio-electrical impedance parameters in severely malnourished children: A cross-sectional study. Clinical Nutrition. 2018;37(2):701-705. https://doi.org/10.1016/j.clnu.2017.02.017

Author

Girma, Tsinuel ; Nielsen, Anne-Louise Hother ; Kæstel, Pernille ; Abdissa, Alemseged ; Michaelsen, Kim F. ; Friis, Henrik ; Wells, Jonathan C. / Biochemical and anthropometric correlates of bio-electrical impedance parameters in severely malnourished children : A cross-sectional study. I: Clinical Nutrition. 2018 ; Bind 37, Nr. 2. s. 701-705.

Bibtex

@article{308786e48bff4bb4a01a3f923e7f9fdc,
title = "Biochemical and anthropometric correlates of bio-electrical impedance parameters in severely malnourished children: A cross-sectional study",
abstract = "INTRODUCTION: Despite expanding use of bio-impedance (BI), little is known about its pathophysiologic significance and biological correlates OBJECTIVE: Determine correlations of BI parameters with anthropometry and biomarkers of electrolyte homeostasis, inflammation and liver function in children with severe acute malnutrition (SAM).METHODS: We studied Ethiopian children with SAM (mid-arm circumference <11·0 cm or weight-for-height <70{\%} of the NCHS growth reference median and/or nutritional oedema) at hospitalization. Impedance (Z, Ohm), resistance (R, Ohm), reactance (Xc, Ohm) and phase angle (PA, degree) were measured at 50 kHz. R and Xc were height-indexed. Anthropometric Z-scores were calculated. Serum phosphate, Ca, Na, K, Mg, alkaline phosphatase, bilirubin, α1-acid glycoprotein, albumin and haemoglobin were measured. Healthy children were used for BI comparison. Correlates of BI were established using forward selection after comparing models using likelihood ratio test.RESULTS: The sample comprised 55 children with SAM (age 36 ± 24 months; 60{\%} males; 72.7{\%} oedematous) and 80 healthy control children (age 28 ± 15 months; 47.5{\%} males). Oedematous children had the lowest BI parameters compared with reference and non-oedematous children. Similarly, they had lower serum albumin, K and alkaline phosphatase levels than non-oedematous children. Oedema was independent negative correlate of R, Xc and PA. Serum albumin level and weight-for-height Z-score were positive correlates of R, whereas serum calcium and Cl levels were positive correlates of Xc. MUAC correlated positively with PA.CONCLUSION: Nutritional oedema explained the divergence of BI parameters from normality. Soft tissue mass, serum albumin, Ca and Cl accounted for variability of BI parameters in children with SAM.",
keywords = "Correlates, Bio-electrical impedance, Severe acute malnutrition, Biochemical",
author = "Tsinuel Girma and Nielsen, {Anne-Louise Hother} and Pernille K{\ae}stel and Alemseged Abdissa and Michaelsen, {Kim F.} and Henrik Friis and Wells, {Jonathan C}",
note = "CURIS 2018 NEXS 100",
year = "2018",
doi = "10.1016/j.clnu.2017.02.017",
language = "English",
volume = "37",
pages = "701--705",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Biochemical and anthropometric correlates of bio-electrical impedance parameters in severely malnourished children

T2 - A cross-sectional study

AU - Girma, Tsinuel

AU - Nielsen, Anne-Louise Hother

AU - Kæstel, Pernille

AU - Abdissa, Alemseged

AU - Michaelsen, Kim F.

AU - Friis, Henrik

AU - Wells, Jonathan C

N1 - CURIS 2018 NEXS 100

PY - 2018

Y1 - 2018

N2 - INTRODUCTION: Despite expanding use of bio-impedance (BI), little is known about its pathophysiologic significance and biological correlates OBJECTIVE: Determine correlations of BI parameters with anthropometry and biomarkers of electrolyte homeostasis, inflammation and liver function in children with severe acute malnutrition (SAM).METHODS: We studied Ethiopian children with SAM (mid-arm circumference <11·0 cm or weight-for-height <70% of the NCHS growth reference median and/or nutritional oedema) at hospitalization. Impedance (Z, Ohm), resistance (R, Ohm), reactance (Xc, Ohm) and phase angle (PA, degree) were measured at 50 kHz. R and Xc were height-indexed. Anthropometric Z-scores were calculated. Serum phosphate, Ca, Na, K, Mg, alkaline phosphatase, bilirubin, α1-acid glycoprotein, albumin and haemoglobin were measured. Healthy children were used for BI comparison. Correlates of BI were established using forward selection after comparing models using likelihood ratio test.RESULTS: The sample comprised 55 children with SAM (age 36 ± 24 months; 60% males; 72.7% oedematous) and 80 healthy control children (age 28 ± 15 months; 47.5% males). Oedematous children had the lowest BI parameters compared with reference and non-oedematous children. Similarly, they had lower serum albumin, K and alkaline phosphatase levels than non-oedematous children. Oedema was independent negative correlate of R, Xc and PA. Serum albumin level and weight-for-height Z-score were positive correlates of R, whereas serum calcium and Cl levels were positive correlates of Xc. MUAC correlated positively with PA.CONCLUSION: Nutritional oedema explained the divergence of BI parameters from normality. Soft tissue mass, serum albumin, Ca and Cl accounted for variability of BI parameters in children with SAM.

AB - INTRODUCTION: Despite expanding use of bio-impedance (BI), little is known about its pathophysiologic significance and biological correlates OBJECTIVE: Determine correlations of BI parameters with anthropometry and biomarkers of electrolyte homeostasis, inflammation and liver function in children with severe acute malnutrition (SAM).METHODS: We studied Ethiopian children with SAM (mid-arm circumference <11·0 cm or weight-for-height <70% of the NCHS growth reference median and/or nutritional oedema) at hospitalization. Impedance (Z, Ohm), resistance (R, Ohm), reactance (Xc, Ohm) and phase angle (PA, degree) were measured at 50 kHz. R and Xc were height-indexed. Anthropometric Z-scores were calculated. Serum phosphate, Ca, Na, K, Mg, alkaline phosphatase, bilirubin, α1-acid glycoprotein, albumin and haemoglobin were measured. Healthy children were used for BI comparison. Correlates of BI were established using forward selection after comparing models using likelihood ratio test.RESULTS: The sample comprised 55 children with SAM (age 36 ± 24 months; 60% males; 72.7% oedematous) and 80 healthy control children (age 28 ± 15 months; 47.5% males). Oedematous children had the lowest BI parameters compared with reference and non-oedematous children. Similarly, they had lower serum albumin, K and alkaline phosphatase levels than non-oedematous children. Oedema was independent negative correlate of R, Xc and PA. Serum albumin level and weight-for-height Z-score were positive correlates of R, whereas serum calcium and Cl levels were positive correlates of Xc. MUAC correlated positively with PA.CONCLUSION: Nutritional oedema explained the divergence of BI parameters from normality. Soft tissue mass, serum albumin, Ca and Cl accounted for variability of BI parameters in children with SAM.

KW - Correlates

KW - Bio-electrical impedance

KW - Severe acute malnutrition

KW - Biochemical

U2 - 10.1016/j.clnu.2017.02.017

DO - 10.1016/j.clnu.2017.02.017

M3 - Journal article

VL - 37

SP - 701

EP - 705

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 2

ER -

ID: 173947571