A review of recent advances in benchmark dose methodology

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

In this review, recent methodological developments for the benchmark dose (BMD) methodology are summarized. Specifically, we introduce the advances for the main steps in BMD derivation: selecting the procedure for defining a BMD from a predefined benchmark response (BMR), setting a BMR, selecting a dose-response model, and estimating the corresponding BMD lower limit (BMDL). Although the last decade has shown major progress in the development of BMD methodology, there is still room for improvement. Remaining challenges are the implementation of new statistical methods in user-friendly software and the lack of consensus about how to derive the BMDL.

OriginalsprogEngelsk
TidsskriftRisk Analysis
ISSN0272-4332
DOI
StatusE-pub ahead of print - 2 maj 2019

Bibliografisk note

CURIS 2019 NEXS 150
© 2019 Society for Risk Analysis.

ID: 217516837